Drebrin is a key regulator of actin cytoskeleton in neuronal cells which is critical for synaptic plasticity, neuritogenesis, and neuronal migration. It is also known to orchestrate a cross-talk between actin and microtubules. Decreased level of drebrin is a hallmark of multiple neurodegenerative disorders such as Alzheimer's disease. Despite its established importance in health and disease, we still have a lot to learn about drebrin's interactome and its effects on cytoskeletal dynamics. This review aims to summarize the recently reported novel effects of drebrin on actin and its regulators. Here I will also reflect on the most recent progress made in understanding of the role of drebrin isoforms and posttranslational modifications on its functionality.
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Review Article| March 19 2021
Effects of neuronal drebrin on actin dynamics
Elena E. Grintsevich
1Department of Chemistry and Biochemistry, California State University, Long Beach (CSULB), Long Beach, California 90840, U.S.A.
2Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, California 90095, U.S.A.
Correspondence: Elena E. Grintsevich (firstname.lastname@example.org)
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Elena E. Grintsevich; Effects of neuronal drebrin on actin dynamics. Biochem Soc Trans 30 April 2021; 49 (2): 685–692. doi: https://doi.org/10.1042/BST20200577
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