Defining the genome-wide chromatin landscape has been a goal of experimentalists for decades. Here we review highlights of these efforts, from seminal experiments showing discontinuities in chromatin structure related to gene activation to extensions of these methods elucidating general features of chromatin related to gene states by exploiting deep sequencing methods. We also review chromatin conformational capture methods to identify patterns in long-range interactions between genomic loci.
Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin
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Luke T. Marr, Prasoon Jaya, Laxmi N. Mishra, Jeffrey J. Hayes; Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin. Biochem Soc Trans 28 February 2022; 50 (1): 199–212. doi: https://doi.org/10.1042/BST20210959
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