Aging is characterized by a functional decline in organism fitness over time due to a complex combination of genetic and environmental factors [ 1–4]. With an increasing elderly population at risk of age-associated diseases, there is a pressing need for research dedicated to promoting health and longevity through anti-aging interventions. The roundworm Caenorhabditis elegans is an established model organism for aging studies due to its short life cycle, ease of culture, and conserved aging pathways. These benefits also make the worm well-suited for high-throughput screening (HTS) methods to study biomarkers of the molecular changes, cellular dysfunction, and physiological decline associated with aging. Within this review, we offer a summary of recent advances in HTS techniques to study biomarkers of aging in C. elegans.
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Cover Image
Cover Image
A bright-field image of aged condensates and fibrillar aggregates of C-terminal domain of transactive response DNA-binding protein 43 is shown. In the center is a schematic representation of the molecular vibrations of the amide-I band, which directly reports on protein secondary structural features that can be measured by Raman spectroscopy. Representative Raman spectra from aged protein droplets (magenta) and aggregates (yellow) clearly show structural differences, exemplifying the utility and versatility of Raman spectroscopy for studies of protein aggregation. For further information, see the review in this issue by Ramos and Lee, pages 1121–1130. Image created by Sashary Ramos.
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