Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms aimed at maintaining energy homeostasis in mammals. When the diet is rich in carbohydrates, secreted insulin stimulates the expression of genes for enzymes involved in glucose utilization (glucokinase, L-type pyruvate kinase and lipogenic enzymes) and inhibits genes for enzymes involved in glucose production (phosphenolpyruvate carboxykinase). The mechanisms by which insulin controls the expression of these genes have been poorly understood. Recently, the transcription factor sterol-regulatory-element-binding protein 1c has been proposed as a key mediator of insulin transcriptional effects. Here we review the evidence that has led to this proposal and the consequences for our understanding of insulin effects in physiological or pathological conditions.
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August 2001
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Conference Article|
August 01 2001
Sterol-regulatory-element-binding protein I c mediates insulin action on hepatic gene expression
P. Ferré;
P. Ferré
1
1INSERM Unit 465, Centre de Recherches Biomédicales des Cordeliers, Université Paris VI, 15, rue de I'École de Médecine, 75270, Paris Cedex 06, France
1To whom correspondence should be addressed (e-mail pferre@bhdc.jussieu.fr)
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M. Foretz;
M. Foretz
1INSERM Unit 465, Centre de Recherches Biomédicales des Cordeliers, Université Paris VI, 15, rue de I'École de Médecine, 75270, Paris Cedex 06, France
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D. Azzout-Marniche;
D. Azzout-Marniche
1INSERM Unit 465, Centre de Recherches Biomédicales des Cordeliers, Université Paris VI, 15, rue de I'École de Médecine, 75270, Paris Cedex 06, France
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D. Bécard;
D. Bécard
1INSERM Unit 465, Centre de Recherches Biomédicales des Cordeliers, Université Paris VI, 15, rue de I'École de Médecine, 75270, Paris Cedex 06, France
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F. Foufelle
F. Foufelle
1INSERM Unit 465, Centre de Recherches Biomédicales des Cordeliers, Université Paris VI, 15, rue de I'École de Médecine, 75270, Paris Cedex 06, France
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Publisher: Portland Press Ltd
Received:
February 13 2001
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2001 Biochemical Society
2001
Biochem Soc Trans (2001) 29 (4): 547–552.
Article history
Received:
February 13 2001
Citation
P. Ferré, M. Foretz, D. Azzout-Marniche, D. Bécard, F. Foufelle; Sterol-regulatory-element-binding protein I c mediates insulin action on hepatic gene expression. Biochem Soc Trans 1 August 2001; 29 (4): 547–552. doi: https://doi.org/10.1042/bst0290547
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