Carnitine palmitoyltransferase I is assumed to be rate limiting for β-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit β-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for β-oxidation in the heart.
Carnitine palmitoyl transferase I and the control of myocardial β-oxidation flux
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S. Eaton, K. Fukumoto, N. Paladio Duran, A. Pierro, L. Spitz, P. A. Quant, K. Bartlett; Carnitine palmitoyl transferase I and the control of myocardial β-oxidation flux. Biochem Soc Trans 1 May 2001; 29 (2): 245–249. doi: https://doi.org/10.1042/bst0290245
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