The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.

Abbreviations used: AMPK, AMP-activated protein kinase; AMPKK, AMPK kinase; HMGR, 3-hydroxy-3-methylglutaryl-CoA reductase; GBD, glycogen-binding domain; AICAR, 5-amino-4-imidazolecarboxamide riboside; PFK-2, 6-phosphofructo-2-kinase; mTOR, mammalian target of rapamycin; eEF, eukaryotic initiation factor.

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Author notes

AMPK 2002: 2nd International Meeting on AMP-activated Protein Kinase, a Biochemical Society-sponsored meeting held at University of Dundee, Scotland, 12–14 September 2002