Lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are closely related endotoxin-binding proteins that function in a co-ordinated manner to facilitate an integrated host response to invading Gram-negative bacteria. Differences in the structure and function of BPI and LBP, as well as differences in their mobilization, permit highly sensitive pro-inflammatory responses to small numbers of bacteria at the onset of bacterial invasion and, later, efficient elimination of viable bacteria and their remnants and of endotoxin-driven inflammation.

Abbreviations used: BPI, bactericidal/permeability-increasing protein; GNB, Gram-negative bacteria; LBP, lipopolysaccharide-binding protein; LOS, lipo-oligosaccharide; LPS, lipopolysaccharide; OM, outer membrane; PMN, polymorphonuclear leucocyte(s) (neutrophils); TLR, Toll-like receptor; the prefixes s and m denote soluble and membrane respectively.

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Author notes

BPI-Like Proteins in Oral and Airway Epithelia a meeting held at Holiday Inn, Ventura, California, U.S.A., 7 February 2003