Genome data as well as biochemical studies have indicated that – as a peculiarity within hyperthermophilic Archaea – Thermoproteus tenax uses three different pathways for glucose metabolism, a variant of the reversible EMP (Embden–Meyerhof–Parnas) pathway and two different modifications of the ED (Entner–Doudoroff) pathway, a non-phosphorylative and a semi-phosphorylative version. An overview of the three different pathways is presented and the physiological function of the variants is discussed.

Abbreviations used: EMP, Embden–Meyerhof–Parnas; ED, Entner–Doudoroff; GAP, glyceraldehyde 3-phosphate; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GAPN, non-phosphorylating, highly allosteric GAPDH; GAPOR, ferredoxin-dependent glyceraldehyde-3-phosphate oxidoreductase; KDG, 2-keto-3-deoxy gluconate; KDPG, 2-keto-3-deoxy-6-phosphogluconate.

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Author notes

Thermophiles 2003, a held at University of Exeter, 15–19 September 2003