Mammals express three class V myosins. Myosin Va is widely expressed, but enriched in the brain, testes and melanocytes, myosin Vb is expressed ubiquitously, and myosin Vc is believed to be epithelium-specific. Myosin Va is the best characterized of the three and plays a key role in the transport of cargo to the plasma membrane. Its cargo includes cell-surface receptors, pigment and organelles such as the endoplasmic reticulum. It is also emerging that RNA and RNA-BPs (RNA-binding proteins) make up another class of myosin Va cargo. It has long been established that the yeast class V myosin, Myo4p, transports mRNAs along actin cables into the growing bud, and now several groups have reported a similar role for class V myosins in higher eukaryotes. Myosin Va has also been implicated in the assembly and maintenance of P-bodies (processing bodies), cytoplasmic foci that are involved in mRNA storage and degradation. The present review examines the evidence that myosin Va plays a role in the transport and turnover of mRNA.
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December 2012
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Conference Article|
November 21 2012
Roles for myosin Va in RNA transport and turnover
Mary W. McCaffrey;
Mary W. McCaffrey
1Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
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Andrew J. Lindsay
Andrew J. Lindsay
1
1Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
1To whom correspondence should be addressed (emaila.lindsay@ucc.ie).
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Publisher: Portland Press Ltd
Received:
July 09 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2012 The Authors Journal
2012
Biochem Soc Trans (2012) 40 (6): 1416–1420.
Article history
Received:
July 09 2012
Citation
Mary W. McCaffrey, Andrew J. Lindsay; Roles for myosin Va in RNA transport and turnover. Biochem Soc Trans 1 December 2012; 40 (6): 1416–1420. doi: https://doi.org/10.1042/BST20120172
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