Biochemical Society Transactions (2018) 46; 1191–1202; DOI: 10.1042/BST20170574

The authors have found an error in Figure 1 of their review which they would like to correct. In the original version the outer set of arrows pointed in the incorrect direction. The correct version is:

Cycle of DNA methylation in human cells and during development (adapted from [11]).

Figure 1.
Cycle of DNA methylation in human cells and during development (adapted from [11]).

DNA methylation patterns are generated during development and germ cell differentiation by de novo methyltransferases and kept through DNA replication by maintenance methylation. DNA methylation can be lost through passive or active demethylation. Typically, Dnmt1 is considered to be a maintenance enzyme, whereas Dnmt3a and Dnmt3b are regarded as de novo methyltransferases (TET, ten eleven translocation enzyme; TDG, thymineâ DNA glycosylase)

Figure 1.
Cycle of DNA methylation in human cells and during development (adapted from [11]).

DNA methylation patterns are generated during development and germ cell differentiation by de novo methyltransferases and kept through DNA replication by maintenance methylation. DNA methylation can be lost through passive or active demethylation. Typically, Dnmt1 is considered to be a maintenance enzyme, whereas Dnmt3a and Dnmt3b are regarded as de novo methyltransferases (TET, ten eleven translocation enzyme; TDG, thymineâ DNA glycosylase)