Fluorescence fluctuation spectroscopy: an invaluable microscopy tool for uncovering the biophysical rules for navigating the nuclear landscape
Is there a role for prostanoid-mediated inhibition of IL-6 trans-signalling in the management of pulmonary arterial hypertension?
An integrated transcriptional switch at the β-selection checkpoint determines T cell survival, development and leukaemogenesis
Visualizing the inner life of microbes: practices of multi-color single-molecule localization microscopy in microbiology
The cover image depicts the maximum projection of the Z-Stack of an organoid of ductal cells derived from the Kras mutated mouse model. Shown in red, the expression of E-Cadherin and in blue DAPI. As you can see from the picture, once the cells start to lose the conformation and invade the extracellular matrix–in this case matrigel–they lose their epithelial marker (represented by the expression of E-Cadherin). For more information, see the article by Lanfredini and colleagues (961–971) in this issue. Image courtesy of Simone Lanfredini.