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February 1999
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ISSN 0300-5127
EISSN 1470-8752
In this Issue
667th Leicester Meeting
From genomics to aetiology in the multifactorial disease type-1 diabetes
Biochem Soc Trans (1999) 27 (1): A1.
Screening for CCKA binding inhibitors: A comparison of combinatorial chemistry approaches
Biochem Soc Trans (1999) 27 (1): A35.
Immunolocalisation of matrix metalloproteinase-3 (stromelysin-1) in carotid artery plaques
Biochem Soc Trans (1999) 27 (1): A43.
Hyaluronic Acid Fragments Activate NFκB in ECV304 Cells Via Its Principal Cell Surface Receptor CD44
Biochem Soc Trans (1999) 27 (1): A43.
The effect of oestrogen on the metabolism of chylomicron cholesterol in the rat in vivo
Biochem Soc Trans (1999) 27 (1): A50.
The conversion of chylomicrons of different fatty acid composition to chylomicron remnants in vivo
Biochem Soc Trans (1999) 27 (1): A51.
Structure and mechanism of the bacterial protein toxin, pneumolysin
Robert Gilbert; Jamie Rossjohn; Michael Parker; Timothy Mitchell; Arthur Rowe; Shaoxia Chen; José Jiménez; Helen Saibil; Olwyn Byron; Peter Andrew
Biochem Soc Trans (1999) 27 (1): A55.
Phorbol Ester-Induced Juxtamembrane Cleavage of Angiotensin-Converting Enzyme is not Inhibited by a Disulfide-Bridged Stalk
Sylva L. U. Schwager; Anthony J. Chubb; Renate R. Scholle; Kevin Naidoo; Wolf F. Brandt; Christoph Eckerskorn; Edward D. Sturrock; Mario R. W. Ehlers
Biochem Soc Trans (1999) 27 (1): A56.
PHOTO-INDUCED INTERNAL ELECTRON TRANSFER IN NITRITE REDUCTASE FROM PSEUDOMONUS AERUGINOSA
E. K. Wilson; A. Bellelli; P. Brzezinski; M. Arese; S. Grasso; S. Liberti; F. Cutruzzolà; M. Brunori
Biochem Soc Trans (1999) 27 (1): A57.
Cytochrome P-450 BM3: NMR, Modelling, Mutagenesis and Substrate Specifity
Biochem Soc Trans (1999) 27 (1): A57.
Structure/Function Studies on R289K Mutant Flavocytochrome b2
Christopher G. Mowat; Andrew D. Pike; Stephen K. Chapman; Graeme A. Reid; Muriel Gondry; Florence Lederer
Biochem Soc Trans (1999) 27 (1): A57.
Characterisation of l-Mandelate Dehydrogenase From Rhodotorula graminis
Biochem Soc Trans (1999) 27 (1): A58.
The effect of protein kinase C on dynamin and endocytosis in Schizosacchromyces pombe
Biochem Soc Trans (1999) 27 (1): A59.
The Role of Calcium in Muscarinic Receptor Activation of ERK and JNK Pathways
Biochem Soc Trans (1999) 27 (1): A59.
VASOPRESSIN INDUCED TRANSLOCATION OF S100 PROTEINS IN RENAL TISSUE DISCS IN VITRO
Biochem Soc Trans (1999) 27 (1): A59.
The nutritional toxicity of sweet lupin (Lupinus angustifolius) seed proteins
Biochem Soc Trans (1999) 27 (1): A59.
Biosensors: Into the 21st Century
Design of molecular biosensor surfaces for screening ligand-receptor interactions by functional assay
Biochem Soc Trans (1999) 27 (1): A27.
BIACORE — AN AFFINITY BIOSENSOR FOR CHARACTERISATION OF BIOMOLECULAR INTERACTIONS
Biochem Soc Trans (1999) 27 (1): A28.
Employment of Quinohemoprotein Alcoholdehydrogenase from Gluconobacter sp. 33 Entrapped into Polypyrrole Film for Creation of Reagentless Alcohol Biosensor
Arūnas Ramanavičius; Wolfgang Schuhmann; Katja Habermüller; Valdas Laurinavičius; Liucia Marcinkevičiene; Irena Bachmatova; Lo Gorton; Elizabeth Csoregi
Biochem Soc Trans (1999) 27 (1): A52.
Biological Fluids Alter The Surface Chemistry Of Nanostructured Silicon Semiconductors
Biochem Soc Trans (1999) 27 (1): A52.
The Viability Of Mammalian Cells On Nanostructured Silicon Semiconductors
Biochem Soc Trans (1999) 27 (1): A53.
CHARACTERISATION OF THE INTERACTION OF PROTHROMBIN WITH IMMOBILISED PHOSPHOLIPID MEMBRANES
Biochem Soc Trans (1999) 27 (1): A53.
Does Biochemistry Have a Core?
Endocrine Control of Perinatal Programming in Health and Disease
The maternal, fetal and postnatal somatotrophic axes in intra-uterine growth retardation
Biochem Soc Trans (1999) 27 (1): A4.
PERINATAL HORMONE LEVELS AND THEIR ROLE IN NORMAL/ABNORMAL DEVELOPMENT AND FUNCTION OF THE MALE REPRODUCTIVE SYSTEM
Biochem Soc Trans (1999) 27 (1): A5.
GENDER-SPECIFIC BRAIN FORMATION OF OESTROGEN IN BEHAVIOURAL DEVELOPMENT
Biochem Soc Trans (1999) 27 (1): A5.
DEIODINASE PROTECTION OF THE FETUS FROM THYROID HORMONES
D. L. St. Germain; V. A. Galton; J. Bates; W. Croteau; J. Davey; A. Hernandez; E. Martinez; M. J. Schneider
Biochem Soc Trans (1999) 27 (1): A6.
Intrauterine programming of hypertension: the role of the renin-angiotensin system
Biochem Soc Trans (1999) 27 (1): A6.
Neuroendocrine Adaptations of the Fetus to Nutrient Restriction
Biochem Soc Trans (1999) 27 (1): A7.
Programming of Hepatic and Peripheral Tissue Insulin Sensitivity by Maternal Protein Restriction
Biochem Soc Trans (1999) 27 (1): A7.
MATERNAL NUTRITION AND ENDOCRINE PROGRAMMING OF FETAL ADIPOSE TISSUE DEVELOPMENT
Biochem Soc Trans (1999) 27 (1): A7.
Pre-adrenarche Androgens and Glucocorticoids and Blood Pressure Control
Biochem Soc Trans (1999) 27 (1): A7.
A role for the endogenous cannabinoid, anandamide, in the human placenta
Biochem Soc Trans (1999) 27 (1): A48.
DEXAMETHASONE ADMINISTRATION IN ADULTHOOD LEADS TO CARDIAC PROTEIN KINASE C EXPRESSION REMINISCENT OF EARLY DEVELOPMENT
Biochem Soc Trans (1999) 27 (1): A49.
The effect of maternal protein deficiency on the expression of the growth arrest specific gene 6 (gas6) in the fetal kidney
Biochem Soc Trans (1999) 27 (1): A49.
DEVELOPMENTAL CHANGES IN THE APPEARANCE OF LEPTIN IN OVINE ADIPOSE TISSUE
Biochem Soc Trans (1999) 27 (1): A50.
Enzyme Catalysis: Structure, Dynamics and Chemistry
The structure of bovine mitochondrial F1-ATPase, an example of rotary catalysis
A. G. W. Leslie; J. P. Abrahams; K. Braig; R. Lutter; R. I. Menz; G. L. Orriss; M. J. van Raaij; J. E. Walker
Biochem Soc Trans (1999) 27 (1): A2.
Time-resolved intermediate trapping and X-ray crystallographic studies of enzyme mechanism: Isocitrate dehydrogenase and nuclease catalysts
Barry L. Stoddard; Jill Bolduc; Dave Dyer; Eric Galburt; Bruce Cohen; Michael Brubaker; Andrew Mesecar; Daniel E. Koshland; Bill Scott; Karen Flick; Melissa Jurica
Biochem Soc Trans (1999) 27 (1): A2.
Galactose and Amine Oxidases: making the most of Tyrosine Residues
Biochem Soc Trans (1999) 27 (1): A2.
A Single Amino Acid (Glu146) governs the substrate specificity of human catecholamine sulfotransferase SULT1A3
Biochem Soc Trans (1999) 27 (1): A36.
Investigation of Cytochrome P450 3A4 by Surface Enhanced Resonance Raman Scattering (SERRS)
Biochem Soc Trans (1999) 27 (1): A36.
EVALUATION OF A KINETIC APPROACH TO THE DETERMINATION OF CATALYTIC SITE CONTENT IN ENZYMES AND ENZYME-LIKE CATALYSTS
Biochem Soc Trans (1999) 27 (1): A37.
Investigation of electrostatic and hydrogen bonding interactions of caricain and caricain D158N with time-dependent inhibitors
SYEED HUSSAIN; KIMBERLEY K. ALLEN; IAN F. CONNERTON; NICOLA J. CUMMINGS; SHERAZ GUL; AKAVISH KHAN; MARK A.J. TAYLOR; EMRYS W. THOMAS; CHANDRA VERMA; KEITH BROCKLEHURST
Biochem Soc Trans (1999) 27 (1): A37.
STRUCTURAL STUDIES OF HISTIDINES IN ZINC β-LACTAMASES AND THEIR INTERACTIONS WITH INHIBITORS
Biochem Soc Trans (1999) 27 (1): A37.
Investigation of Chymotrypsin-ligand complexes using Infrared spectroscopy: a model for the study of β-Lactamases?
Biochem Soc Trans (1999) 27 (1): A38.
CHARACTERISATION OF DICTYOSTELIUM MYOSIN II MUTATED IN THE CONVERTER REGION
Biochem Soc Trans (1999) 27 (1): A38.
Kinetic Mechanism of Aspartate-Beta-Semi-Aldehyde Dehydrogenase and it's interaction with small molecule inhibitors
C. J. Greenwood; K. J. Moore; T. Allinson; G. Burton; C. Frydych; F. Harrington; N. Nicholson; M. Hartley; M. Pearson; A. J. Pope
Biochem Soc Trans (1999) 27 (1): A38.
Site-directed mutagenesis in the active site of Rhodotorula gracilis D-amino acid oxidase
Biochem Soc Trans (1999) 27 (1): A38.
Mechanistic insights into substrate turnover and inhibition of metallo-β-lactamases
Biochem Soc Trans (1999) 27 (1): A39.
The structure, function, and convergent evolution of intron-encoded homing endonucleases
Biochem Soc Trans (1999) 27 (1): A39.
β-Carbonyl Substituted Glutathione Conjugates as Inhibitors of O. volvulus GST2
Biochem Soc Trans (1999) 27 (1): A39.
Structure and Function Studies of Hydroxymethylbilane Synthase using SRS and ESRF
P. F. Faulder; Y. P. Nieh; J. Raftery; J. Habash; A. Haedener; S. McSweeney; F. Schotte; T. Ursby; M. Wulff; A. W. Thompson; J. R. Helliwell
Biochem Soc Trans (1999) 27 (1): A39.
Enzyme-Catalysed Electron/Radical Transfer
FLAVOCYTOCHROMES: STRUCTURES AND IMPLICATIONS FOR ELECTRON TRANSFER
Biochem Soc Trans (1999) 27 (1): A29.
Flavocytochromes: Transceivers and relays in biological electron transfer
Biochem Soc Trans (1999) 27 (1): A29.
Structural studies of the flavoprotein reductase component of the P450 mono-oxygenase system
Biochem Soc Trans (1999) 27 (1): A29.
Flavocytochrome P-450 BM3: Electron transfer and its control in a model P-450
Biochem Soc Trans (1999) 27 (1): A29.
Electron transfer in trimethylamine dehydrogenase and electron transferring flavoprotein
Biochem Soc Trans (1999) 27 (1): A30.
Methylamine Dehydrogenase: Structure and Function of Electron Transfer Complexes
Biochem Soc Trans (1999) 27 (1): A30.
Ribonucleotide Reductase — Coupled Electron/Proton Transfer Mechanisms
Biochem Soc Trans (1999) 27 (1): A30.
ELECTRON TRANSFER AND COUPLED PROCESSES IN PROTEIN FILM VOLTAMMETRY
Biochem Soc Trans (1999) 27 (1): A31.
Characterisation of a Leu-Trn Mutant of the Flavodehydrogenase Domain of Flavocytochrome b2
Biochem Soc Trans (1999) 27 (1): A43.
Determinants of substrate binding in flavocytochrome P-450 BM3
Biochem Soc Trans (1999) 27 (1): A44.
Catalytic properties of key active site mutants of flavocytochrome P-450 BM3
Biochem Soc Trans (1999) 27 (1): A44.
The interaction of nitric oxide with flavocytochrome P-450 BM3
Biochem Soc Trans (1999) 27 (1): A44.
Analysis of flavocytochrome P-450 BM3 using resonance Raman spectroscopy
Biochem Soc Trans (1999) 27 (1): A45.
Altering the Electron Acceptor Specificity of Flavocytochrome b2
Biochem Soc Trans (1999) 27 (1): A45.
Stepwise electron transfer to 6-S cysteinyl FMN in trimethylamine dehydrogenase
Biochem Soc Trans (1999) 27 (1): A45.
Substrate inhibition in wild-type and mutant trimethylamine dehydrogenases
Biochem Soc Trans (1999) 27 (1): A46.
Electron transfer in ω-hydroxylation: analysis of rubredoxin reductase and rubredoxin
Biochem Soc Trans (1999) 27 (1): A46.
Structure and mechanism of an opiate-transforming redox enzyme: morphinone reductase
Biochem Soc Trans (1999) 27 (1): A46.
Study of Intramolecular Electron Transfer and Catalytic Action of Quinohemoprotein- Alcohol Dehydrogenase from Gluconobacter sp. 33
Arūnas Ramanavičius; Julija Razumiene; Valdas Laurinavičius; Liucija Marcinkevičiene; Irina Bachmatova; Rolandas Meškys; Rolandas Rudomanskis
Biochem Soc Trans (1999) 27 (1): A46.
Site directed mutagenesis of an active site residue in Salmonella typhimurium dehydroquinate synthase
Biochem Soc Trans (1999) 27 (1): A47.
Construction and Expression of the Truncated forms of the katG gene from Mycobacterium tuberculosis
Biochem Soc Trans (1999) 27 (1): A47.
Expression and preliminary purification of a Zn2+ form of Escherichia coli dehydroquinate synthase
Biochem Soc Trans (1999) 27 (1): A47.
Purification of 5-enolpyruvylshikimate-3-phosphate synthase from Haemophilus influenzae
Biochem Soc Trans (1999) 27 (1): A47.
G-Protein-Coupled Receptor Signalling in the Central Nervous System
Diversity in the signaling and regulation of G protein-coupled receptors
Graeme Milligan; D. Alex. Groake; Alison MacLean; Richard Ward; Chee Wai Fong; Antonella Cavalli; Tomas Drmota
Biochem Soc Trans (1999) 27 (1): A24.
INVOLVEMENT OF THE N-TERMINUS OF NEURONAL CALCIUM CHANNELS IN G-PROTEIN MODULATION
Biochem Soc Trans (1999) 27 (1): A25.
CELL CYCLE-DEPENDENT COUPLING OF VASOPRESSIN V1-RECEPTOR TO Gq/11, AND Gi3
Biochem Soc Trans (1999) 27 (1): A25.
Organisation of G protein-Coupled Receptors and Ion Channels at the Synapse
Biochem Soc Trans (1999) 27 (1): A26.
Role of G protein-coupled receptors in adaptative neuronal processes
Biochem Soc Trans (1999) 27 (1): A26.
Dopamine receptor antagonists or inverse agonists as antipsychotics?
Biochem Soc Trans (1999) 27 (1): A26.
Muscarinic receptor (M1)-evoked increase in [Ca2+]i, in SH-SYSY cells inhibits noradrenaline release
Biochem Soc Trans (1999) 27 (1): A32.
CHARACTERISATION OF PURINOCEPTORMEDIATED Ca2+ OSCILLATIONS IN L-FIBROBLASTS
Biochem Soc Trans (1999) 27 (1): A32.
Cultured spinal cord cells take-up and release [3H]-noradrenaline: Evidence for Intrinsic noradrenergic neurons
Biochem Soc Trans (1999) 27 (1): A32.
How does the internalization of G protein coupled receptor agonists relate to the internalization of their receptors?
Biochem Soc Trans (1999) 27 (1): A32.
Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's disease and Parkinson's disease cases
Biochem Soc Trans (1999) 27 (1): A33.
Molecular determinants for high affinity binding to the vasopressin V1a receptor
Biochem Soc Trans (1999) 27 (1): A33.
Naloxone benzoylhydrazone inhibits K+ evoked glutamate release from rat brain slices
Biochem Soc Trans (1999) 27 (1): A33.
Effects of steroidal neuromuscular blocking drugs on [3H]noradrenaline release from SH-SY5Y cells
Biochem Soc Trans (1999) 27 (1): A33.
GnRH RECEPTORS WITH ADDED CYTOPLASMIC C-TERMINAL TAILS UNDERGO ACCELERATED b-ARRESTIN-DEPENDENT INTERNALISATION
Biochem Soc Trans (1999) 27 (1): A34.
Calmodulin dependence of presynaptic metabotropic glutamate receptor signalling
Vincent O'Connor; Oussama El Far; Elisa Bofill-Cardona; Christian Nanoff; Michael Freissmuth; José M. Airas; Heinrich Betz; Stefan Böhm
Biochem Soc Trans (1999) 27 (1): A35.
Harnessing Plant Metabolites for Industry: Tools, Systems and Implementation
Genetic Engineering Of Plant Secondary Metabolism Using Particle Bombardment
Mark J. Leech; Daniel Burtin; Frédérique Hilliou; Dermott O'Callaghan; Natalia Palacios; Pedro Rocha; Leo Zeef; Paul Christou
Biochem Soc Trans (1999) 27 (1): A15.
MICROMANIPULATION MEASUREMENT OF PLANT CELL MECHANICAL PROPERTIES
Biochem Soc Trans (1999) 27 (1): A15.
Flavonoids — antioxidants in vino veritas or the cup that cheers?
Biochem Soc Trans (1999) 27 (1): A16.
Fatty acid oxidation, tasteful tunes played on the green notes
Biochem Soc Trans (1999) 27 (1): A17.
GENETIC ENGINEERING OF THE PLANT ISOPRENOID PATHWAY: ALL THINGS CONSIDERED?
Biochem Soc Trans (1999) 27 (1): A17.
Membrane Protein Secretases
SHEDDING OF THE INTERLEUKIN-6 RECEPTOR: MECHANISMS AND PHYSIOLOGICAL CONSEQUENCES
Biochem Soc Trans (1999) 27 (1): A22.
Interleukin-6 Receptor (IL-6R) Shedding: A Role for Members of the ADAM Family
Biochem Soc Trans (1999) 27 (1): A23.
Angiotensin converting enzyme and the amyloid precursor protein secretases
Biochem Soc Trans (1999) 27 (1): A23.
Proteolytic processing of β-amyloid precursor protein and presenilins
Biochem Soc Trans (1999) 27 (1): A23.
MECHANISMS CONTROLLING THE SHEDDING OF TRANSMEMBRANE MOLECULES
Biochem Soc Trans (1999) 27 (1): A24.
PROTEASE-ACTIVATED RECEPTORS: NOVEL FUNCTIONS FOR SERINE PROTEASES
Biochem Soc Trans (1999) 27 (1): A24.
The effect of Aβ-amyloid peptides on the uptake of choline and noradrenaline by the human neuroblastoma SH-SYSY
Biochem Soc Trans (1999) 27 (1): A53.
Detergent Solubility and Proteolytic Processing of the Prion Protein
Biochem Soc Trans (1999) 27 (1): A54.
Use of Neoepitope Antibodies to Study Membrane Processing of CD23
Biochem Soc Trans (1999) 27 (1): A54.
Sequence analysis and characterisation of the rat orthologue of TNFα converting enzyme (TACE)
A. J. Beaumont; J. A. Jury; J. Frayne; R. Devos; J. Van der Heyden; L. Jeffery; G. J. Price; L. Hall
Biochem Soc Trans (1999) 27 (1): A55.
Role of internalisation in the regulation of phospholipase C-coupled receptor desensitisation and resensitisation
Biochem Soc Trans (1999) 27 (1): A55.
Modelling Metabolism
Live Control of the Living Cell
Wally C. van Heeswijk; Barbara M. Bakker; Bas Teusink; Boris N. Kholodenko; Oscar J. G. Somsen; Jacky L. Snoep; Hans V. Westerhoff
Biochem Soc Trans (1999) 27 (1): A18.
Design of Gene Circuitry by Natural Selection: Analysis of the Lactose Catabolic System in E. coli
Biochem Soc Trans (1999) 27 (1): A19.
New insights into metabolic pathway optimization by analogy with industrial manufacturing processes
Biochem Soc Trans (1999) 27 (1): A19.
Control and structural design of glycolysis: An evolutionary approach
Biochem Soc Trans (1999) 27 (1): A20.
Traditional concepts of metabolic control mislead more than enlighten
Biochem Soc Trans (1999) 27 (1): A20.
Towards understanding the extra's of metabolic pathways: the implementation of quantitative analyses
Biochem Soc Trans (1999) 27 (1): A21.
Regulation of ATP synthesis and proton handling in ischaemically exercising skeletal muscle
Biochem Soc Trans (1999) 27 (1): A48.
Simulation of The Epidermal Growth Factor Signal Transduction Pathway
Biochem Soc Trans (1999) 27 (1): A48.
Computer simulation and evolution strategies in the study of rat heart glucose metabolism
Biochem Soc Trans (1999) 27 (1): A48.
Oestrogen Metabolism and Breast Cancer Risk
Introduction: Importance of oestrogen, xenoestrogen and phytoestrogen metabolism in breast cancer risk?
Biochem Soc Trans (1999) 27 (1): A13.
Oestrogen and phytoestrogen metabolism: role of the gut microflora
Biochem Soc Trans (1999) 27 (1): A13.
PHYTOESTROGEN SULPHOCONJUGATES AS INHIBITORS OF STEROL SULPHATASE
Biochem Soc Trans (1999) 27 (1): A14.
4-Hydroxylation of Estrogens as a Marker of Breast Cancer Risk
Biochem Soc Trans (1999) 27 (1): A14.
Regulation of Steroid Sulphatase and Oestradiol 17β-hydroxysteroid dehydrogenase in breast cancer
Biochem Soc Trans (1999) 27 (1): A15.
The Biology of Hyaluronan
Properties of the hyaluronan synthase from Group A Streptococcus pyogenes
Biochem Soc Trans (1999) 27 (1): A10.
Mammalian Hyaluronan (HA) Syntheses: Investigation of Functional Relationships In Vivo
Biochem Soc Trans (1999) 27 (1): A10.
Mammalian hyaluronan synthases and their functions
Naoki Itano; Mamoru Yoshida; Yoichi Yamada; Petros Lenas; Andrew P. Spicer; John A. McDonald; Koji Kimata
Biochem Soc Trans (1999) 27 (1): A10.
The conformations of hyaluronan in aqueous solution: comparison of theory and experiment
Biochem Soc Trans (1999) 27 (1): A11.
Hyaluronan Receptors: the Regulation of the Cytoskeleton and their Impact on Skin Wound
Biochem Soc Trans (1999) 27 (1): A12.
The Chondrocyte Pericellular Matrix: A Model for Hyaluronan-Mediated Cell-Matrix Interactions
Biochem Soc Trans (1999) 27 (1): A12.
Hyaluronan bound to CD44 on keratinocytes is displaced by hyaluronan decasaccharides and not hexasaccharides
Biochem Soc Trans (1999) 27 (1): A40.
Epidermal growth factor regulates keratinocyte hyaluronan metabolism
Biochem Soc Trans (1999) 27 (1): A40.
CHARACTERISATION OF TRANS-SYNOVIAL FLOW ‘PLATEAU’ CAUSED BY HIGH MOLECULAR WEIGHT HYALURONAN
Biochem Soc Trans (1999) 27 (1): A41.
A SIMPLE THEORY FOR CONCENTRATION POLARISATION DURING ULTRAFILTRATION ACROSS A PARTIALLY REFLECTING MEMBRANE IN A STIRRED CELL
Biochem Soc Trans (1999) 27 (1): A41.
CO-LOCALISATION OF A PROTEOGLYCAN EPITOPE AND TYPE X COLLAGEN BY HUMAN INTERVERTEBRAL DISC CELLS IN VITRO
Biochem Soc Trans (1999) 27 (1): A42.
