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Volume 28, Issue 2

February 2000

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Cover Image

Cover Image
Front Matter
Table of Contents

ISSN 0300-5127

EISSN 1470-8752

In this Issue

670th Meeting

670th Meeting

Aging and the Immune System

Cell senescence and human aging: where's the link?

R. G. A. Faragher

Biochem Soc Trans (2000) 28 (2): 221–226.

Abstract

View Articletitled, Cell senescence and human aging: where's the link?

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Replicative senescence as a barrier to human cancer

E. K. Parkinson; J. Munro; K. Steeghs; V. Morrison; H. Ireland; N. Forsyth; S. Fitzsimmons; S. Bryce

Biochem Soc Trans (2000) 28 (2): 226–233.

Abstract

View Articletitled, Replicative senescence as a barrier to human cancer

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Regulation of cell cycle re-entry by growth, survival and stress signalling pathways

S.J. Cook; K. Balmanno; A. Garner; T. Millar; C. Taverner; D. Todd

Biochem Soc Trans (2000) 28 (2): 233–240.

Abstract

View Articletitled, Regulation of cell cycle re-entry by growth, survival and stress signalling pathways

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Telomere diminution as a cause of immune failure in old age: an unfashionable demurral

R. A. Miller

Biochem Soc Trans (2000) 28 (2): 241–245.

Abstract

View Articletitled, Telomere diminution as a cause of immune failure in old age: an unfashionable demurral

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Measurement of telomere length in haematopoietic cells using in situ hybridization techniques

U. M. Martens; V. Brass; M. Engelhardt; S. Glaser; C. F. Waller; W. Lange; C. Schmoor; S. S. S. Poon; P. M. Lansdorp

Biochem Soc Trans (2000) 28 (2): 245–250.

Abstract

View Articletitled, Measurement of telomere length in haematopoietic cells using in situ hybridization techniques

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Immunosenescence: potential causes and strategies for reversal

R. Aspinall; D. Andrew

Biochem Soc Trans (2000) 28 (2): 250–254.

Abstract

View Articletitled, Immunosenescence: potential causes and strategies for reversal

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Regulation of apoptosis and replicative senescence in CD8⁺ T cells from patients with viral infections

M.V.D. Soares; M.K. Maini; P.C.L. Beverley; M. Salmon; A.N. Akbar

Biochem Soc Trans (2000) 28 (2): 255–258.

Abstract

View Articletitled, Regulation of apoptosis and replicative senescence in CD8+ T cells from patients with viral infections

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Biosensors and Novel Bioanalytical Methods

Electrochemical investigation of cellobiose oxidation by cellobiose dehydrogenase in the presence of cytochrome c as mediator

V. Fridman; U. Wollenberger; V. Bogdanovskaya; F. Lisdat; T. Ruzgas; A. Lindgren; L. Gorton; F. W. Scheller

Biochem Soc Trans (2000) 28 (2): 63–70.

Abstract

View Articletitled, Electrochemical investigation of cellobiose oxidation by cellobiose dehydrogenase in the presence of cytochrome c as mediator

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Two-photon fluorescence excitation in detection of biomolecules

E. Soini; N. J. Meltola; A. E. Soini; J. Soukka; J. T. Soini; P. E. Hänninen

Biochem Soc Trans (2000) 28 (2): 70–74.

Abstract

View Articletitled, Two-photon fluorescence excitation in detection of biomolecules

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Phosphorescent porphyrin probes in biosensors and sensitive bioassays

D. B. Papkovsky; T. O'Riordan; A. Soini

Biochem Soc Trans (2000) 28 (2): 74–77.

Abstract

View Articletitled, Phosphorescent porphyrin probes in biosensors and sensitive bioassays

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Double-stranded DNA liquid-crystalline dispersions as biosensing units

Y. M. Yevdokimov

Biochem Soc Trans (2000) 28 (2): 77–81.

Abstract

View Articletitled, Double-stranded DNA liquid-crystalline dispersions as biosensing units

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Rapid antibody biosensor assays for environmental analysis

A. J. Killard; M. R. Smyth; K. Grennan; L. Micheli; G. Palleschi

Biochem Soc Trans (2000) 28 (2): 81–84.

Abstract

View Articletitled, Rapid antibody biosensor assays for environmental analysis

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Direct electron transfer catalysed by enzymes: application for biosensor development

A. Ghindilis

Biochem Soc Trans (2000) 28 (2): 84–89.

Abstract

View Articletitled, Direct electron transfer catalysed by enzymes: application for biosensor development

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The use of electrochemically grown polymers on metallized electrodes to reduce electrode fouling in biological matrices

D. J. Daly; C. K. O'Sullivan; G. G. Guilbault

Biochem Soc Trans (2000) 28 (2): 89–93.

Abstract

View Articletitled, The use of electrochemically grown polymers on metallized electrodes to reduce electrode fouling in biological matrices

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Cell Survival and Apoptosis

Regulation of survival signals from the insulin-like growth factor-I receptor

R. O'Connor; C. Fennelly; D. Krause

Biochem Soc Trans (2000) 28 (2): 47–51.

Abstract

View Articletitled, Regulation of survival signals from the insulin-like growth factor-I receptor

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Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins

R. J. Lutz

Biochem Soc Trans (2000) 28 (2): 51–56.

Abstract

View Articletitled, Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins

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GSH extrusion and the mitochondrial pathway of apoptotic signalling

S. Coppola; L. Ghibelli

Biochem Soc Trans (2000) 28 (2): 56–61.

Abstract

View Articletitled, GSH extrusion and the mitochondrial pathway of apoptotic signalling

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Chemoprotection

An overview of bioactivation of chemical carcinogens

H. R. Glatt

Biochem Soc Trans (2000) 28 (2): 1–6.

Abstract

View Articletitled, An overview of bioactivation of chemical carcinogens

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Modulation of signal-transduction pathways by chemopreventive agents

M. M. Manson; K. A. Holloway; L. M. Howells; E. A. Hudson; S. M. Plummer; M. S. Squires; S. A. Prigent

Biochem Soc Trans (2000) 28 (2): 7–12.

Abstract

View Articletitled, Modulation of signal-transduction pathways by chemopreventive agents

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Diet and colorectal cancer prevention

S. A. Bingham

Biochem Soc Trans (2000) 28 (2): 12–16.

Abstract

View Articletitled, Diet and colorectal cancer prevention

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Human metabolic pathways of dietary flavonoids and cinnamates

G. Williamson; A. J. Day; G. W. Plumb; D. Couteau

Biochem Soc Trans (2000) 28 (2): 16–22.

Abstract

View Articletitled, Human metabolic pathways of dietary flavonoids and cinnamates

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Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals

N. M. O'Brien; J. A. Woods; S. A. Aherne; Y. C. O'Callaghan

Biochem Soc Trans (2000) 28 (2): 22–26.

Abstract

View Articletitled, Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals

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Chemical modulation of chemotherapy resistance in cultured oesophageal carcinoma cells

D. Sheehan; G. Meade

Biochem Soc Trans (2000) 28 (2): 27–32.

Abstract

View Articletitled, Chemical modulation of chemotherapy resistance in cultured oesophageal carcinoma cells

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The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

J. D. Hayes; S. A. Chanas; C.J. Henderson; M. McMahon; C. Sun; G.J. Moffat; C. R. Wolf; M. Yamamoto

Biochem Soc Trans (2000) 28 (2): 33–41.

Abstract

View Articletitled, The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

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Cytochrome P450s and chemoprevention

C.J. Henderson; A. Sahraouei; C. R. Wolf

Biochem Soc Trans (2000) 28 (2): 42–46.

Abstract

View Articletitled, Cytochrome P450s and chemoprevention

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Evolution of Sequences, Structures and Genomes

Evidence in favour of ancient octaploidy in the vertebrate genome

T.J. Gibson; J. Spring

Biochem Soc Trans (2000) 28 (2): 259–264.

Abstract

View Articletitled, Evidence in favour of ancient octaploidy in the vertebrate genome

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Searching for the ideal forms of proteins

W. R. Taylor

Biochem Soc Trans (2000) 28 (2): 264–269.

Abstract

View Articletitled, Searching for the ideal forms of proteins

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Using the CATH domain database to assign structures and functions to the genome sequences

F. Pearl; A. E. Todd; J. E. Bray; A. C. R. Martin; A. A. Salamov; M. Suwa; M. B. Swindells; J. M. Thornton; C. A. Orengo

Biochem Soc Trans (2000) 28 (2): 269–275.

Abstract

View Articletitled, Using the CATH domain database to assign structures and functions to the genome sequences

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Origins and evolution of AIDS viruses: estimating the time-scale

P. M. Sharp; E. Bailes; F. Gao; B. E. Beer; V. M. Hirsch; B. H. Hahn

Biochem Soc Trans (2000) 28 (2): 275–282.

Abstract

View Articletitled, Origins and evolution of AIDS viruses: estimating the time-scale

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Growth Factors and Cytokines at the Maternal/Fetal Interface

Leucocyte populations and cytokine regulation in human uteroplacental tissues

G. S. Vince; P. M. Johnson

Biochem Soc Trans (2000) 28 (2): 191–195.

Abstract

View Articletitled, Leucocyte populations and cytokine regulation in human uteroplacental tissues

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Decidual natural-killer-cell interaction with trophoblast: cytolysis or cytokine production?

Y. W. Loke; A. King

Biochem Soc Trans (2000) 28 (2): 196–198.

Abstract

View Articletitled, Decidual natural-killer-cell interaction with trophoblast: cytolysis or cytokine production?

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Growth factor-extracellular matrix synergy in the control of trophoblast invasion

J. D. Aplin; H. Lacey; T. Haigh; C. J. P. Jones; C.-P. Chen; M. Westwood

Biochem Soc Trans (2000) 28 (2): 199–202.

Abstract

View Articletitled, Growth factor-extracellular matrix synergy in the control of trophoblast invasion

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Structure—function relations in the human placenta

P. Dockery; J. Bermingham; D. Jenkins

Biochem Soc Trans (2000) 28 (2): 202–208.

Abstract

View Articletitled, Structure—function relations in the human placenta

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HLA-G in the human placenta: expression and potential functions

P. Le Bouteiller

Biochem Soc Trans (2000) 28 (2): 208–212.

Abstract

View Articletitled, HLA-G in the human placenta: expression and potential functions

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Role of hormone-controlled T-cell cytokines in the maintenance of pregnancy

M.-P. Piccinni; E. Maggi; S. Romagnani

Biochem Soc Trans (2000) 28 (2): 212–215.

Abstract

View Articletitled, Role of hormone-controlled T-cell cytokines in the maintenance of pregnancy

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Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia

J. Bermingham; D. Jenkins; T. McCarthy; M. O'Brien

Biochem Soc Trans (2000) 28 (2): 215–219.

Abstract

View Articletitled, Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia

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Organisms, Organs, Cells and Organelles: in vivo and in vitro Experimental Systems

The multifunctional protein At MFP2 is co-ordinately expressed with other genes of fatty acid β-oxidation during seed germination in Arabidopsis thaliana (L.) Heynh

P.J. Eastmond; I. A. Graham

Biochem Soc Trans (2000) 28 (2): 95–99.

Abstract

View Articletitled, The multifunctional protein At MFP2 is co-ordinately expressed with other genes of fatty acid β-oxidation during seed germination in Arabidopsis thaliana (L.) Heynh

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Studying metabolic regulation in human muscle

G. J. Kemp

Biochem Soc Trans (2000) 28 (2): 100–103.

Abstract

View Articletitled, Studying metabolic regulation in human muscle

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Use of in vivo and in vitro techniques for the study of the effects of insulin on hepatic triacylglycerol secretion in different insulinaemic states

V. A. Zammit

Biochem Soc Trans (2000) 28 (2): 103–109.

Abstract

View Articletitled, Use of in vivo and in vitro techniques for the study of the effects of insulin on hepatic triacylglycerol secretion in different insulinaemic states

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The use of in situ haemoglobin-free perfused liver in metabolic-control analysis

S. Soboll; G. C. Brown

Biochem Soc Trans (2000) 28 (2): 109–113.

Abstract

View Articletitled, The use of in situ haemoglobin-free perfused liver in metabolic-control analysis

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Perfused heart studies to investigate lipid metabolism

R. D. Evans; M.J. Bennett; D. Hauton

Biochem Soc Trans (2000) 28 (2): 113–120.

Abstract

View Articletitled, Perfused heart studies to investigate lipid metabolism

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NMR spectroscopy and imaging of the neonatal brain

C. E. Cooper; J. S. Wyatt

Biochem Soc Trans (2000) 28 (2): 121–126.

Abstract

View Articletitled, NMR spectroscopy and imaging of the neonatal brain

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Adipocyte studies: systems for investigating effects of growth hormone and other chronically acting hormones

R. G. Vernon

Biochem Soc Trans (2000) 28 (2): 126–131.

Abstract

View Articletitled, Adipocyte studies: systems for investigating effects of growth hormone and other chronically acting hormones

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The isolated hepatocyte preparation: 30 years on

M. N. Berry; J. W. Phillips

Biochem Soc Trans (2000) 28 (2): 131–135.

Abstract

View Articletitled, The isolated hepatocyte preparation: 30 years on

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Hepatocyte couplets

R. Coleman; M. G. Roma

Biochem Soc Trans (2000) 28 (2): 136–140.

Abstract

View Articletitled, Hepatocyte couplets

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Lipid metabolism in peroxisomes: enzymology, functions and dysfunctions of the fatty acid α- and β-oxidation systems in humans

R. J. A. Wanders; E. G. van Grunsven; G. A. Jansen

Biochem Soc Trans (2000) 28 (2): 141–149.

Abstract

View Articletitled, Lipid metabolism in peroxisomes: enzymology, functions and dysfunctions of the fatty acid α- and β-oxidation systems in humans

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The molecular basis of lysosomal storage diseases and their treatment

B. Winchester; A. Vellodi; E. Young

Biochem Soc Trans (2000) 28 (2): 150–154.

Abstract

View Articletitled, The molecular basis of lysosomal storage diseases and their treatment

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Does the mitochondrial transcription-termination complex play an essential role in controlling differential transcription of mitochondrial DNA?

S. P. Selwood; Z. M. A. Chrzanowska-Lightowlers; R. N. Lightowlers

Biochem Soc Trans (2000) 28 (2): 154–159.

Abstract

View Articletitled, Does the mitochondrial transcription-termination complex play an essential role in controlling differential transcription of mitochondrial DNA?

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Muscle fibres: applications for the study of the metabolic consequences of enzyme deficiencies in skeletal muscle

S. Vielhaber; A. Kudin; R. Schröder; C. E. Elger; W. S. Kunz

Biochem Soc Trans (2000) 28 (2): 159–164.

Abstract

View Articletitled, Muscle fibres: applications for the study of the metabolic consequences of enzyme deficiencies in skeletal muscle

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Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases

F. N. Gellerich; S. Trumbeckaite; J. R. Opalka; E. Seppet; H. N. Rasmussen; C. Neuhoff; S. Zierz

Biochem Soc Trans (2000) 28 (2): 164–169.

Abstract

View Articletitled, Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases

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Mitochondria and cell death

A. P. Halestrap; E. Doran; J. P. Gillespie; A. O'Toole

Biochem Soc Trans (2000) 28 (2): 170–177.

Abstract

View Articletitled, Mitochondria and cell death

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The mitochondrial trifunctional protein: centre of a β-oxidation metabolon?

S. Eaton; T. Bursby; B. Middleton; M. Pourfarzam; K. Mills; A. W. Johnson; K. Bartlecc

Biochem Soc Trans (2000) 28 (2): 177–182.

Abstract

View Articletitled, The mitochondrial trifunctional protein: centre of a β-oxidation metabolon?

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The carnitine acyltransferases: modulators of acyl-CoA-dependent reactions

R. R. Ramsay

Biochem Soc Trans (2000) 28 (2): 182–186.

Abstract

View Articletitled, The carnitine acyltransferases: modulators of acyl-CoA-dependent reactions

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Leishmania pyruvate kinase: the crystal structure reveals the structural basis of its unique regulatory properties

L. A. Fothergill-Gilmore; D. J. Rigden; P. A. M. Michels; S. E. V. Phillips

Biochem Soc Trans (2000) 28 (2): 186–190.

Abstract

View Articletitled, Leishmania pyruvate kinase: the crystal structure reveals the structural basis of its unique regulatory properties

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Issues

Cover Image

670th Meeting

Aging and the Immune System

Biosensors and Novel Bioanalytical Methods

Cell Survival and Apoptosis

Chemoprotection

Evolution of Sequences, Structures and Genomes

Growth Factors and Cytokines at the Maternal/Fetal Interface

Organisms, Organs, Cells and Organelles: in vivo and in vitro Experimental Systems

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