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February 2001
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ISSN 0300-5127
EISSN 1470-8752
In this Issue
672nd Sussex Meeting
Fatty Acid Oxidation and Ketone Body Metabolism
Travels with CPT I - from liver to germ cell with stops in between
Biochem Soc Trans (2001) 29 (1): A1.
Alterations in malonyl CoA control of fatty acid oxidation in the ischemic heart
Biochem Soc Trans (2001) 29 (1): A2.
Peroxisomal fatty acid alpha- and beta-oxidation in humans: new insights into enzymology, substrate specificities, metabolite transport and peroxisomal diseases
R. J. A. Wanders; S. Ferdinandusse; G. A. Jansen; E. G. van Grusven; H. R. Waterham; C. W. T. van Roermund; P. Vreken
Biochem Soc Trans (2001) 29 (1): A2.
Fuel sensing mechanisms integrating lipid and carbohydrate utilisation
Biochem Soc Trans (2001) 29 (1): A2.
The life and work of Dermot Hedley (Derek) Williamson (1929–1998)
Biochem Soc Trans (2001) 29 (1): A3.
Impact of the intra-mitochondrial enzyme on fatty acid oxidation
Biochem Soc Trans (2001) 29 (1): A3.
Structure-function relationships of malonyl-CoA-sensitive carnitine palmitoyltransferase (CPT I)
Biochem Soc Trans (2001) 29 (1): A3.
The role of the carnitine system in peroxisomal fatty acid oxidation
Biochem Soc Trans (2001) 29 (1): A4.
Further insights in peroxisomal lipid breakdown via α- and β-oxidation
Biochem Soc Trans (2001) 29 (1): A4.
Clinical consequences of defects in peroxisomal beta-oxidation enzymes
Biochem Soc Trans (2001) 29 (1): A4.
Peroxisome proliferator-activated receptors: fatty acid sensors in atherosclerosis and cancer
Biochem Soc Trans (2001) 29 (1): A4.
The hormonal and nutritional regulation of liver CRT 1 gene transcription
Biochem Soc Trans (2001) 29 (1): A5.
Control of neonatal hepatic fatty acid oxidation and ketogenesis by CPT 1 in health and disease
Biochem Soc Trans (2001) 29 (1): A5.
Post-transcriptional regulation of rat carnitine octonoyltransferase
Biochem Soc Trans (2001) 29 (1): A6.
Regulation of acetyl-CoA carboxylase in the control of fatty acid synthesis and fatty acid oxidation
Biochem Soc Trans (2001) 29 (1): A6.
Fatty acid oxidation and ketogenesis in the brain: rationales, mechanisms and clinical implications
Biochem Soc Trans (2001) 29 (1): A6.
Protein Engineering of Peroxidases and Cytochrome P450
Crystal structures of peroxidase high oxidation state intermediates
Biochem Soc Trans (2001) 29 (1): A6.
Plant peroxidases: structure of substrate complexes and their mechanistic implications
Biochem Soc Trans (2001) 29 (1): A7.
Catalase versus peroxidase activity. Towards understanding the bifunctional activity of catalase-peroxidase
Biochem Soc Trans (2001) 29 (1): A7.
Directed evolution of a fungal peroxidase and pathway engineering to boost haem expression in a fungal host
Biochem Soc Trans (2001) 29 (1): A8.
An old activity in the P450 superfamily (CYP51) and a new story of drugs and resistance
Biochem Soc Trans (2001) 29 (1): A9.
A combinatorial mutagenesis approach for cytochromes P450: study of mutant CYP1 As obtained by segment-directed mutagenesis
Biochem Soc Trans (2001) 29 (1): A9.
Predicting drug pharmacokinetics in Man from in vitro metabolism studies
Biochem Soc Trans (2001) 29 (1): A9.
A kinetic model for NO synthase that helps explain relationships between heme reduction, heme-NO complex formation, and NO release
Biochem Soc Trans (2001) 29 (1): A10.
The Glycobiology of Development
Heparan Sulfate Proteoglycans are critical for the organization of the extracellular distribution of Wingless
Biochem Soc Trans (2001) 29 (1): A10.
Structure and bioactivity of heparan sulphate from the 2-O-sulphotransferase mutant mouse
Biochem Soc Trans (2001) 29 (1): A11.
MUC1, glycans and the cell surface barrier to embryo implantation in human
Biochem Soc Trans (2001) 29 (1): A11.
Glycosylation changes during differentiation of the murine uterine epithelium for implantation of the embryo
Biochem Soc Trans (2001) 29 (1): A11.
The role of keratan sulphate chains in the maintenance of corneal transparency
Biochem Soc Trans (2001) 29 (1): A12.
Alternative perlecan isoforms regulate myofilament assembly and muscle cell growth in C. elegans
Biochem Soc Trans (2001) 29 (1): A13.
Proteoglycans in developmental patterning: from growth control to synapse assembly
S. B. Selleck; R. Waldrip; B. Fox; W. Staatz; J. Rawson; M. Lee; K. Chhor; J. Reuter; J. Knepper; M. Ramaswami
Biochem Soc Trans (2001) 29 (1): A13.
Dynamic expression of heparan sulphate biosynthetic enzymes in developing mouse brain
Jeremy Turnbull; Scott Guimond; Katherine Drummond; Susan Turner; Kirsty Turner; Magdalena Kita; Kay Grobe; Jun-ichi Aikawa; Hiroko Habuchi; Koji Kimata; Jeff Esko; Miriam Ford-Perriss
Biochem Soc Trans (2001) 29 (1): A13.
Steroids, Steroid Receptors and Disease
Introduction and overview: new advances in the understanding of the role of steroids and steroid receptors in disease
Biochem Soc Trans (2001) 29 (1): A14.
The chemoprotective action of genistein may involve enhanced transforming growth factor-beta activity
Biochem Soc Trans (2001) 29 (1): A14.
Functional and structural analysis of the androgen receptor in Kennedy's disease
Biochem Soc Trans (2001) 29 (1): A14.
New Frontiers in DNA Repair
Error prone replication of undamaged and damaged DNA by human DNA polymerase
Biochem Soc Trans (2001) 29 (1): A16.
Roles of DNA polymerase ζ and Rev1 protein in eukaryotic mutagenesis and translesion replication
C. W. Lawrence; P. E. M. Gibbs; R. S. Murante; X.-D. Wang; Z. Li; T. P. McManus; J. R. Nelson; D. C. Hinkle; V. M. Maher
Biochem Soc Trans (2001) 29 (1): A16.
All three SOS-inducible DNA polymerases (II, IV and V) can engage into DNA replication replacing Pol III at lesion sites
Biochem Soc Trans (2001) 29 (1): A16.
Gene conversion is a prominent DNA repair pathway in mammalian cells
Biochem Soc Trans (2001) 29 (1): A17.
Roles of recombination in DNA damage repair
Jeroen Essers; T. L. Raoul Tan; Mies L. G. Dronkert; Elisabetta Citterio; Coen Paulusma; Dejan Ristic; Claire Wyman; Cecile Beerens; Jan de Wit; Jan H. J. Hoeijmakers; Roland Kanaar
Biochem Soc Trans (2001) 29 (1): A17.
Role of the Bloom's syndrome helicase in suppression of genomic stability
Biochem Soc Trans (2001) 29 (1): A17.
Holliday junctions and the interplay of DNA replication, transcription and repair
Biochem Soc Trans (2001) 29 (1): A17.
DNA repair and cancer predisposition in cells which lack the breast cancer susceptibility gene, BRCA2
Biochem Soc Trans (2001) 29 (1): A18.
Role of Specific Cytokines and Cytokine Receptors in Fetal Growth
Cytokines and cytokine-receptors in fetal growth and development - an overview
Biochem Soc Trans (2001) 29 (1): A18.
The ontogenesis of prolactin (PRL) receptors in the human fetus: roles in fetal development
Biochem Soc Trans (2001) 29 (1): A18.
Transcriptional regulation in the placenta during normal at comprimised fetal growth
Biochem Soc Trans (2001) 29 (1): A18.
Prolactin receptor and its actions: signal transduction pathways as determined by prolactin receptor knockout mice
Biochem Soc Trans (2001) 29 (1): A19.
Prolactin receptor heterogeneity: processing and signaling of the long and short isoforms during development
Biochem Soc Trans (2001) 29 (1): A19.
Ontogenesis of leptin expression in placental and fetal tissues: does leptin have a functional role?
Biochem Soc Trans (2001) 29 (1): A19.
Leptin and its role in pregnancy and fetal development - an overview
Biochem Soc Trans (2001) 29 (1): A20.
Leptin secretion from fat cells: role in the growth and development of different fat depots
Biochem Soc Trans (2001) 29 (1): A20.
Leptin and uncoupling proteins (UCPs) gene expression: molecular endpoints of fetal development
Biochem Soc Trans (2001) 29 (1): A20.
Fetal and neonatal adipose tissue maturation: a primary site of cytokine and cytokine-receptor action?
Biochem Soc Trans (2001) 29 (1): A20.
Physiological and pathological regulation of feto-placental leptin expression
Biochem Soc Trans (2001) 29 (1): A21.
Molecular defects in leptin and their implications for pregnancy and fetal growth
Biochem Soc Trans (2001) 29 (1): A21.
MISCELLANEOUS
The role of tyrosine residues of protein L in the binding reaction with human IgG
Biochem Soc Trans (2001) 29 (1): A22.
The effect of chronic hypoxia on the changes of reactive oxygen species and apoptosis in the pancreas
Biochem Soc Trans (2001) 29 (1): A22.
The mouse Nudt7 nudix hydrolase gene encodes a peroxisomal coenzyme A diphosphatase homologous to yeast Pcd 1p
Biochem Soc Trans (2001) 29 (1): A22.
Cloning and functional expression of human peroxisomal 2,4-dienoyl-CoA reductase
Biochem Soc Trans (2001) 29 (1): A23.
Is a microsomal aldehyde dehydrogenase involved in the degradation of 3-methyl branched fatty acids?
Biochem Soc Trans (2001) 29 (1): A23.
Beta-oxidation of docosahexaenoic acid and tetracosahexaenoic acid in isolated rat hepatocytes and human fibroblasts
Biochem Soc Trans (2001) 29 (1): A23.
Characterization of mutations in six L-CPT-I deficient patients
N. F. Brown; R. S. Mullur; V. Esser; M. J. Bennett; J. M. Saudubray; A. S. Feigenbaum; J. A. Kobari; P. M. MacLeod; J. D. McGarry; J. C. Cohen
Biochem Soc Trans (2001) 29 (1): A24.
Impact of the intramitochondrial enzyme organization on fatty acid β-oxidation
Biochem Soc Trans (2001) 29 (1): A24.
Molecular analysis of hepatic carnitine palmitoy ltransferase 1 deficiency in an extended Hutterite family
C. Prip-Buus; L. Thuillier; N. Abadi; C. Prasad; L. Dilling; F. Demaugre; C. Greenberg; S. Gobin; J. Girard; J-P. Bonnefont
Biochem Soc Trans (2001) 29 (1): A24.
The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes
Biochem Soc Trans (2001) 29 (1): A24.
Organization of the liver-type human carnitine palmitoyltransferase 1 (CPT1A) gene
S. Gobin; J. P. Bonnefont; C. Prip-Buus; C. Mugnier; F. Demaugre; M. Ferrec; J. Girard; L. Thuillier
Biochem Soc Trans (2001) 29 (1): A25.
Glutamine increases fatty acid oxidation in neonatal hepatocytes from both control and endotoxaemic rats
Biochem Soc Trans (2001) 29 (1): A25.
Shifted cooperation of desaturation and oxidation of palmitic acid in rat liver
Biochem Soc Trans (2001) 29 (1): A25.
Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model
Biochem Soc Trans (2001) 29 (1): A26.
Supplementation of peroxisome deficient mice with docosahexaenoic acid and plasmalogen precursors
Biochem Soc Trans (2001) 29 (1): A26.
Biochemical and genetic studies in a family with shortchaim acyl-COA dehydrogenase (SCAD) deficiency
Biochem Soc Trans (2001) 29 (1): A26.
Abnormal cardiolipin and phosphatidylglycerol remodeling in barth syndrome
Biochem Soc Trans (2001) 29 (1): A27.
System properties of ATP supply and demand in exercising skeletal muscle in vivo
Biochem Soc Trans (2001) 29 (1): A27.
Ontogeny of peroxisomal lipid-metabolizing pathways in the mouse
Biochem Soc Trans (2001) 29 (1): A28.
Phylogenetic relationships of carnitine- and choline acyltransferases
Biochem Soc Trans (2001) 29 (1): A28.
Regulation of rat heart lipid metabolism during mildronateinduced L-carnitine deficiency
Biochem Soc Trans (2001) 29 (1): A28.
Influence of the N-terminal domain of rat L-CPT1 on the folding state of its catalytic C-terminal domain
Biochem Soc Trans (2001) 29 (1): A29.
Azole sterol biosynthesis inhibitors as anti mycobacterial agents
Biochem Soc Trans (2001) 29 (1): A30.
A new model of DNA binding by bacteriophage T5 exonuclease, a flap endonuclease
Biochem Soc Trans (2001) 29 (1): A30.
Differential binding of Mn(II) to bacteriophage T5 5′ nuclease and vital role of metal site II in exonucleolytic cleavage
Biochem Soc Trans (2001) 29 (1): A30.
Processing of methylated DNA by the Escherichia coli AlkB protein
Biochem Soc Trans (2001) 29 (1): A31.
The stimulation of DNA-PK by radiation-induced complex single strand breaks
Biochem Soc Trans (2001) 29 (1): A31.
The green tea polyphenol, epigallocatechin-3-gallate, protects against the oxidative damage of UVA radiation
Biochem Soc Trans (2001) 29 (1): A32.
Blood from preeclamptic women and peroxidised normotensive blood contain an extractable vasoactive factor
Biochem Soc Trans (2001) 29 (1): A32.
NMR investigations into the binding of azo dyes to horse-radish peroxidase
Biochem Soc Trans (2001) 29 (1): A32.
Efficient hydroxylation catalysts based upon P450 enzymes derived from Actinomycetes
Biochem Soc Trans (2001) 29 (1): A33.
Cytochromes P450 as drug targets in Mycobacterium tuberculosis
Biochem Soc Trans (2001) 29 (1): A33.
Reconstituting the electron transport system in cytochrome P450 Biol
Biochem Soc Trans (2001) 29 (1): A34.
Characterisation of the HRP distal pocket mutants R38H/H42E, R38H/F41A/H42E and R38A/F41H/H42E
Biochem Soc Trans (2001) 29 (1): A35.
The reaction of ascorbate peroxidase with hydrogen peroxide: evidence for a protein radical
Biochem Soc Trans (2001) 29 (1): A35.
Escherichia coli expression and in vitro folding optimization of Pleurotus eryngii peroxidase
Biochem Soc Trans (2001) 29 (1): A35.
A proposed role for serine hydroxymethyltransferase in the control of the thymidylate cycle
Biochem Soc Trans (2001) 29 (1): A36.
Inactivation of ascorbate peroxidase and horseradish peroxidases A2 and C by hydrogen peroxide
Biochem Soc Trans (2001) 29 (1): A36.
A structural determinant of phenolic substrate oxidation in Horseradish Peroxidase C
Biochem Soc Trans (2001) 29 (1): A36.
azole resistance mechanisms in clinical isolates of Candida albicans and Cryptococcus neoformans from intensive care patients
Biochem Soc Trans (2001) 29 (1): A37.
Phenylalanine-393: Controlling the electronic properties of the heme in Flavocytochrome P450 BM3
Biochem Soc Trans (2001) 29 (1): A37.
Kinetic characterisation of the catalase-peroxidase enzyme from Mycobacterium tuberculosis
Biochem Soc Trans (2001) 29 (1): A37.
Probing the stability of the class II peroxidase from Coprinus cinereus
Biochem Soc Trans (2001) 29 (1): A37.
Site-directed mutants of the active site residues of catalase-peroxidase from Mycobacterium tuberculosis
Biochem Soc Trans (2001) 29 (1): A38.
Engineering a soluble, catalytically self-sufficient human P450 for nanobiotechnology
Biochem Soc Trans (2001) 29 (1): A38.
Detection of polymorphisms in normally grown and growth retarded infants
Biochem Soc Trans (2001) 29 (1): A39.
Cortisol has no effect on prolactin receptor (PRLR) abundance in brown adipose tissue (BAT) in late gestation fetal sheep
Biochem Soc Trans (2001) 29 (1): A39.
Effect of chronic leptin administration on plasma leptin, prolactin and UCP1 in neonatal lambs
Biochem Soc Trans (2001) 29 (1): A39.
Variable longitudinal patterns of leptin expression during human pregnancy
Biochem Soc Trans (2001) 29 (1): A40.
Development of a mammalian screen for the detection of compounds with androgenic activity
Biochem Soc Trans (2001) 29 (1): A41.
AZT-sterol dicarboxylates and sterol-PFA bioesters as novel HIV-provirus inhibitors
Biochem Soc Trans (2001) 29 (1): A41.
Parabens bind directly to recombinant human oestrogen receptor ligand binding domain
Biochem Soc Trans (2001) 29 (1): A41.
Molecular analysis of the glucose-6-phosphatase enzyme system in a family with glycogen storage disease type Ib
Biochem Soc Trans (2001) 29 (1): A42.
LATE ABSTRACTS
Heterologous CYP51 expression to probe altered interactions with azole inhibitors
Biochem Soc Trans (2001) 29 (1): A43.
Probing the activity of agrochemicals against plant and fungal CYP51
Biochem Soc Trans (2001) 29 (1): A43.
Manipulation of P450 in Acinetobacter and application to pollutant degradation
Biochem Soc Trans (2001) 29 (1): A43.
Yeast cytochrome P450 reductase; expression of a soluble and full-length form, kinetic mechanisms and crystallisation
Biochem Soc Trans (2001) 29 (1): A44.
