December 2003
ISSN 0300-5127
EISSN 1470-8752
Keilin Memorial Lecture
Novartis Medal Lecture
679th Meeting of the Biochemical Society
The glucose–fatty acid cycle: a physiological perspective
Biochem Soc Trans (2003) 31 (6): 1115–1119.
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
Biochem Soc Trans (2003) 31 (6): 1120–1124.
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase
Biochem Soc Trans (2003) 31 (6): 1125–1129.
Roles of PPARΔ in the control of muscle development and metabolism
Biochem Soc Trans (2003) 31 (6): 1130–1132.
Myocardial carnitine palmitoyltransferase I as a target for oxidative modification in inflammation and sepsis
Biochem Soc Trans (2003) 31 (6): 1133–1136.
Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with hyperinsulinism: a novel glucose–fatty acid cycle?
Biochem Soc Trans (2003) 31 (6): 1137–1139.
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
Biochem Soc Trans (2003) 31 (6): 1143–1151.
Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling
Biochem Soc Trans (2003) 31 (6): 1152–1156.
Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase
Biochem Soc Trans (2003) 31 (6): 1157–1160.
Extending the glucose/fatty acid cycle: a glucose/adipose tissue cycle
Biochem Soc Trans (2003) 31 (6): 1161–1164.
AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats
Biochem Soc Trans (2003) 31 (6): 1165–1167.
AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2
Biochem Soc Trans (2003) 31 (6): 1168–1170.
VEGF signalling: integration and multi-tasking in endothelial cell biology
Biochem Soc Trans (2003) 31 (6): 1171–1177.
Mechanisms controlling EGF receptor endocytosis and degradation
Biochem Soc Trans (2003) 31 (6): 1178–1181.
The anti-apoptotic response of the Gq/11-coupled muscarinic receptor family
Biochem Soc Trans (2003) 31 (6): 1182–1185.
The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways
Biochem Soc Trans (2003) 31 (6): 1186–1190.
Protease-activated receptor 2: activation, signalling and function
Biochem Soc Trans (2003) 31 (6): 1191–1197.
Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling
Biochem Soc Trans (2003) 31 (6): 1198–1202.
Stress-induced ATP release from and growth modulation of human lens and retinal pigment epithelial cells
Biochem Soc Trans (2003) 31 (6): 1213–1215.
Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways
Biochem Soc Trans (2003) 31 (6): 1216–1219.
Maintaining the permeability barrier during protein trafficking at the endoplasmic reticulum membrane
Biochem Soc Trans (2003) 31 (6): 1227–1231.
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
Biochem Soc Trans (2003) 31 (6): 1232–1237.
Intramembrane proteolysis and post-targeting functions of signal peptides
Biochem Soc Trans (2003) 31 (6): 1243–1247.
Making membrane proteins at the mammalian endoplasmic reticulum
Biochem Soc Trans (2003) 31 (6): 1248–1252.
How does the translocon differentiate between hydrophobic sequences that form part of either a GPI (glycosylphosphatidylinositol)-anchor signal or a stop transfer sequence?
Biochem Soc Trans (2003) 31 (6): 1257–1259.
Retrograde transport of toxins across the endoplasmic reticulum membrane
Biochem Soc Trans (2003) 31 (6): 1260–1262.
Experiment and computer-aided simulation: complementary tools to understand exercise metabolism
Biochem Soc Trans (2003) 31 (6): 1263–1266.
Nutritional status, metabolic responses to exercise and implications for performance
Biochem Soc Trans (2003) 31 (6): 1267–1269.
Modulation of carbohydrate and fat utilization by diet, exercise and environment
Biochem Soc Trans (2003) 31 (6): 1270–1273.
Regulation of PDH activity and isoform expression: diet and exercise
Biochem Soc Trans (2003) 31 (6): 1274–1280.
Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences
Biochem Soc Trans (2003) 31 (6): 1295–1299.
Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling
Biochem Soc Trans (2003) 31 (6): 1300–1301.
Novel peptoids for the detection and suppression of reactive oxygen and nitrogen species
Biochem Soc Trans (2003) 31 (6): 1302–1304.
Oxidative stress and aging – the use of superoxide dismutase/catalase mimetics to extend lifespan
Biochem Soc Trans (2003) 31 (6): 1305–1307.
Cell respiration and formation of reactive oxygen species: facts and artefacts
Biochem Soc Trans (2003) 31 (6): 1308–1311.
Possible role of free oxidation processes in the regulation of reactive oxygen species production in plant mitochondria
Biochem Soc Trans (2003) 31 (6): 1316–1317.
Role of prokaryotic Cu,Zn superoxide dismutase in pathogenesis
Biochem Soc Trans (2003) 31 (6): 1326–1329.
Iron superoxide dismutases: structure and function of an archaic enzyme
Biochem Soc Trans (2003) 31 (6): 1330–1334.
Rotting by radicals – the role of cellobiose oxidoreductase?
Biochem Soc Trans (2003) 31 (6): 1335–1336.
Kinetics of superoxide scavenging by glutathione: an evaluation of its role in the removal of mitochondrial superoxide
Biochem Soc Trans (2003) 31 (6): 1337–1339.
The enzymatic defence against glycation in health, disease and therapeutics: a symposium to examine the concept
Biochem Soc Trans (2003) 31 (6): 1341–1342.
Glyoxalase I – structure, function and a critical role in the enzymatic defence against glycation
Biochem Soc Trans (2003) 31 (6): 1343–1348.
Enzymatic deglycation with amadoriase enzymes from Aspergillus sp. as a potential strategy against the complications of diabetes and aging
Biochem Soc Trans (2003) 31 (6): 1349–1353.
Fructosamine 3-kinase, an enzyme involved in protein deglycation
Biochem Soc Trans (2003) 31 (6): 1354–1357.
Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in the long-term consequences of diabetes mellitus
Biochem Soc Trans (2003) 31 (6): 1364–1366.
Aldose reductase and the importance of experimental design
Biochem Soc Trans (2003) 31 (6): 1367–1371.
Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy
Biochem Soc Trans (2003) 31 (6): 1372–1377.
Glycation in food and metabolic transit of dietary AGEs (advanced glycation end-products): studies on the urinary excretion of pyrraline
Biochem Soc Trans (2003) 31 (6): 1383–1385.
Renal clearance of glycation adducts: anti-glycation defence in uraemia and dialysis
Biochem Soc Trans (2003) 31 (6): 1386–1389.
Toxicity of glyoxals – role of oxidative stress, metabolic detoxification and thiamine deficiency
Biochem Soc Trans (2003) 31 (6): 1390–1393.
Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis
Biochem Soc Trans (2003) 31 (6): 1394–1396.
Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus
Biochem Soc Trans (2003) 31 (6): 1400–1402.
Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids
Biochem Soc Trans (2003) 31 (6): 1403–1405.
Bacterial production of methylglyoxal: a survival strategy or death by misadventure?
Biochem Soc Trans (2003) 31 (6): 1406–1408.
Role of lipids in chemical modification of proteins and development of complications in diabetes
Biochem Soc Trans (2003) 31 (6): 1413–1416.
Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats
Biochem Soc Trans (2003) 31 (6): 1423–1425.
Mass spectrometric analysis of glucose-modified ribonuclease
Biochem Soc Trans (2003) 31 (6): 1426–1427.
Enzymatic deglycation – a new paradigm or an epiphenomenon?
Biochem Soc Trans (2003) 31 (6): 1428–1432.
Application of monoclonal antibody libraries for the measurement of glycation adducts
Biochem Soc Trans (2003) 31 (6): 1438–1440.
Biochemical Society Focused Meetings
Sprouty: a controversial role in receptor tyrosine kinase signalling pathways
Biochem Soc Trans (2003) 31 (6): 1445–1446.
Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-α-lipoic acid
Biochem Soc Trans (2003) 31 (6): 1447–1449.
Rapid S-nitrosothiol metabolism by platelets and megakaryocytes
Biochem Soc Trans (2003) 31 (6): 1450–1452.
Co-localization of cell surface receptors at high spatial resolution by single-particle fluorescence imaging
Biochem Soc Trans (2003) 31 (6): 1453–1455.
Deriving statistical models for predicting peptide tandem MS product ion intensities
Biochem Soc Trans (2003) 31 (6): 1479–1483.
Identification of surrogate markers for determining drug activity using proteomics
Biochem Soc Trans (2003) 31 (6): 1488–1490.
On the structure of protein–protein interaction networks
Biochem Soc Trans (2003) 31 (6): 1491–1496.
Supervised classification for gene network reconstruction
Biochem Soc Trans (2003) 31 (6): 1497–1502.
Analysis and modelling of signal transduction pathways in systems biology
Biochem Soc Trans (2003) 31 (6): 1503–1509.
A probabilistic model for the extraction of expression levels from oligonucleotide arrays
Biochem Soc Trans (2003) 31 (6): 1510–1512.
Reverse engineering of genetic networks with Bayesian networks
Biochem Soc Trans (2003) 31 (6): 1516–1518.
Corrections
Circular dichroism and synchrotron radiation circular dichroism spectroscopy: tools for drug discovery
Biochem Soc Trans (2003) 31 (6): 1531.
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