Volume 35 Issue 5 | Biochemical Society Transactions

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Biochemical Society Awards

Colworth Medal Lecture

The twin-arginine transport system: moving folded proteins across membranes

F. Sargent

Biochem Soc Trans (2007) 35 (5): 835–847.

Abstract

View Articletitled, The twin-arginine transport system: moving folded proteins across membranes

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Life Sciences 2007

Cardiovascular Bioscience

Biochemistry and functional significance of collagen cross-linking

S.P. Robins

Biochem Soc Trans (2007) 35 (5): 849–852.

Abstract

View Articletitled, Biochemistry and functional significance of collagen cross-linking

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Cross-link breakers as a new therapeutic approach to cardiovascular disease

D. Susic

Biochem Soc Trans (2007) 35 (5): 853–856.

Abstract

View Articletitled, Cross-link breakers as a new therapeutic approach to cardiovascular disease

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Mast cells and degradation of pericellular and extracellular matrices: potential contributions to erosion, rupture and intraplaque haemorrhage of atherosclerotic plaques

P.T. Kovanen

Biochem Soc Trans (2007) 35 (5): 857–861.

Abstract

View Articletitled, Mast cells and degradation of pericellular and extracellular matrices: potential contributions to erosion, rupture and intraplaque haemorrhage of atherosclerotic plaques

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Dr Brian Gibberd (1931–2006): a pioneering clinician in Refsum's disease

A.S. Wierzbicki; M.D. Lloyd

Biochem Soc Trans (2007) 35 (5): 862–864.

Abstract

View Articletitled, Dr Brian Gibberd (1931–2006): a pioneering clinician in Refsum's disease

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Peroxisomes, Refsum's disease and the α- and ω-oxidation of phytanic acid

R.J.A. Wanders; J.C. Komen

Biochem Soc Trans (2007) 35 (5): 865–869.

Abstract

View Articletitled, Peroxisomes, Refsum's disease and the α- and ω-oxidation of phytanic acid

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Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH)

C.J. Schofield; M.A. McDonough

Biochem Soc Trans (2007) 35 (5): 870–875.

Abstract

View Articletitled, Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH)

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The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids

M. Casteels; M. Sniekers; P. Fraccascia; G.P. Mannaerts; P.P. Van Veldhoven

Biochem Soc Trans (2007) 35 (5): 876–880.

Abstract

View Articletitled, The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids

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Peroxisomal disorders affecting phytanic acid α-oxidation: a review

A.S. Wierzbicki

Biochem Soc Trans (2007) 35 (5): 881–886.

Abstract

View Articletitled, Peroxisomal disorders affecting phytanic acid α-oxidation: a review

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Is there life after plaque rupture?

C.L. Jackson

Biochem Soc Trans (2007) 35 (5): 887–889.

Abstract

View Articletitled, Is there life after plaque rupture?

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Ion channel switching and activation in smooth-muscle cells of occlusive vascular diseases

D.J. Beech

Biochem Soc Trans (2007) 35 (5): 890–894.

Abstract

View Articletitled, Ion channel switching and activation in smooth-muscle cells of occlusive vascular diseases

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The role of stem cells in vein graft remodelling

Q. Xu

Biochem Soc Trans (2007) 35 (5): 895–899.

Abstract

View Articletitled, The role of stem cells in vein graft remodelling

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Current challenges in coronary stenting: from bench to bedside

A.C. Morton; R.D. Walker; J. Gunn

Biochem Soc Trans (2007) 35 (5): 900–904.

Abstract

View Articletitled, Current challenges in coronary stenting: from bench to bedside

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Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling

M.E. Morley; K. Riches; C. Peers; K.E. Porter

Biochem Soc Trans (2007) 35 (5): 905–907.

Abstract

View Articletitled, Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling

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The potential roles of sphingolipids in vascular smooth-muscle function

G.F. Nixon; F.A. Mathieson; I. Hunter

Biochem Soc Trans (2007) 35 (5): 908–909.

Abstract

View Articletitled, The potential roles of sphingolipids in vascular smooth-muscle function

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Prostacyclin analogues: the next drug-eluting stent?

C. McCormick; R.M. Wadsworth; R.L. Jones; S. Kennedy

Biochem Soc Trans (2007) 35 (5): 910–911.

Abstract

View Articletitled, Prostacyclin analogues: the next drug-eluting stent?

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Signalling

Plasma-membrane calcium pumps and hereditary deafness

M. Brini; F. Di Leva; T. Domi; L. Fedrizzi; D. Lim; E. Carafoli

Biochem Soc Trans (2007) 35 (5): 913–918.

Abstract

View Articletitled, Plasma-membrane calcium pumps and hereditary deafness

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Plasma-membrane Ca²⁺ pumps: structural diversity as the basis for functional versatility

E.E. Strehler; A.G. Filoteo; J.T. Penniston; A.J. Caride

Biochem Soc Trans (2007) 35 (5): 919–922.

Abstract

View Articletitled, Plasma-membrane Ca2+ pumps: structural diversity as the basis for functional versatility

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Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangers

M.P. Kurnellas; K.C. Donahue; S. Elkabes

Biochem Soc Trans (2007) 35 (5): 923–926.

Abstract

View Articletitled, Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangers

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The regulatory function of plasma-membrane Ca²⁺-ATPase (PMCA) in the heart

D. Oceandy; P.J. Stanley; E.J. Cartwright; L. Neyses

Biochem Soc Trans (2007) 35 (5): 927–930.

Abstract

View Articletitled, The regulatory function of plasma-membrane Ca2+-ATPase (PMCA) in the heart

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Spatiotemporal control of cAMP signalling processes by anchored signalling complexes

E. Jarnæss; K. Taskén

Biochem Soc Trans (2007) 35 (5): 931–937.

Abstract

View Articletitled, Spatiotemporal control of cAMP signalling processes by anchored signalling complexes

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cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling

M.J. Lynch; G.S. Baillie; M.D. Houslay

Biochem Soc Trans (2007) 35 (5): 938–941.

Abstract

View Articletitled, cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling

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Ubiquitin signals in the NF-κB pathway

J. Terzic; I. Marinovic-Terzic; F. Ikeda; I. Dikic

Biochem Soc Trans (2007) 35 (5): 942–945.

Abstract

View Articletitled, Ubiquitin signals in the NF-κB pathway

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Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction

N.L. Thomas; C.H. George; A.J. Williams; F.A. Lai

Biochem Soc Trans (2007) 35 (5): 946–951.

Abstract

View Articletitled, Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction

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Sarcoplasmic reticulum calcium leak and cardiac arrhythmias

M.G. Chelu; X.H.T. Wehrens

Biochem Soc Trans (2007) 35 (5): 952–956.

Abstract

View Articletitled, Sarcoplasmic reticulum calcium leak and cardiac arrhythmias

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Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid

H.L. Roderick; D.R. Higazi; I. Smyrnias; C. Fearnley; D. Harzheim; M.D. Bootman

Biochem Soc Trans (2007) 35 (5): 957–961.

Abstract

View Articletitled, Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid

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Rapid discovery of protein interactions by cell-free protein technologies

M. He; M.J. Taussig

Biochem Soc Trans (2007) 35 (5): 962–965.

Abstract

View Articletitled, Rapid discovery of protein interactions by cell-free protein technologies

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Insights into the structure and protein–protein interactions of the pro-apoptotic protein ASPP2

S. Rotem; C. Katz; A. Friedler

Biochem Soc Trans (2007) 35 (5): 966–969.

Abstract

View Articletitled, Insights into the structure and protein–protein interactions of the pro-apoptotic protein ASPP2

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Visualization of protein interactions inside the secretory pathway

B. Nyfeler; H.-P. Hauri

Biochem Soc Trans (2007) 35 (5): 970–973.

Abstract

View Articletitled, Visualization of protein interactions inside the secretory pathway

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Protein–protein interactions in the assembly and subcellular trafficking of the BACE (β-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease

R.B. Parsons; B.M. Austen

Biochem Soc Trans (2007) 35 (5): 974–979.

Abstract

View Articletitled, Protein–protein interactions in the assembly and subcellular trafficking of the BACE (β-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease

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Picking pockets to fuel antimicrobial drug discovery

W.N. Hunter

Biochem Soc Trans (2007) 35 (5): 980–984.

Abstract

View Articletitled, Picking pockets to fuel antimicrobial drug discovery

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Solid-state NMR spectroscopy as a tool for drug design: from membrane-embedded targets to amyloid fibrils

D.A. Middleton

Biochem Soc Trans (2007) 35 (5): 985–990.

Abstract

View Articletitled, Solid-state NMR spectroscopy as a tool for drug design: from membrane-embedded targets to amyloid fibrils

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Magic-angle-spinning NMR spectroscopy applied to small molecules and peptides in lipid bilayers

C. Ader; R. Schneider; K. Seidel; M. Etzkorn; M. Baldus

Biochem Soc Trans (2007) 35 (5): 991–995.

Abstract

View Articletitled, Magic-angle-spinning NMR spectroscopy applied to small molecules and peptides in lipid bilayers

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Targeting the oncogenic protein kinase Cι signalling pathway for the treatment of cancer

A.P. Fields; L.A. Frederick; R.P. Regala

Biochem Soc Trans (2007) 35 (5): 996–1000.

Abstract

View Articletitled, Targeting the oncogenic protein kinase Cι signalling pathway for the treatment of cancer

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Protein kinase Cδ and apoptosis

M.E. Reyland

Biochem Soc Trans (2007) 35 (5): 1001–1004.

Abstract

View Articletitled, Protein kinase Cδ and apoptosis

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Isoform-specific functions of protein kinase C: the platelet paradigm

M.T. Harper; A.W. Poole

Biochem Soc Trans (2007) 35 (5): 1005–1008.

Abstract

View Articletitled, Isoform-specific functions of protein kinase C: the platelet paradigm

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Murine models for chronic lymphocytic leukaemia

A.M. Michie; R. Nakagawa; A.M. McCaig

Biochem Soc Trans (2007) 35 (5): 1009–1012.

Abstract

View Articletitled, Murine models for chronic lymphocytic leukaemia

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Protein kinases, from B to C

A.J. Cameron; M. De Rycker; V. Calleja; D. Alcor; S. Kjaer; B. Kostelecky; A. Saurin; A. Faisal; M. Laguerre; B.A. Hemmings; N. McDonald; B. Larijani; P.J. Parker

Biochem Soc Trans (2007) 35 (5): 1013–1017.

Abstract

View Articletitled, Protein kinases, from B to C

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Functional PKC in vivo analysis using deficient mouse models

M. Leitges

Biochem Soc Trans (2007) 35 (5): 1018–1020.

Abstract

View Articletitled, Functional PKC in vivo analysis using deficient mouse models

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Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic

G.R. Budas; T. Koyanagi; E.N. Churchill; D. Mochly-Rosen

Biochem Soc Trans (2007) 35 (5): 1021–1026.

Abstract

View Articletitled, Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic

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Structure-based optimization of PKCθ inhibitors

L. Mosyak; Z. Xu; D. Joseph-McCarthy; N. Brooijmans; W. Somers; D. Chaudhary

Biochem Soc Trans (2007) 35 (5): 1027–1031.

Abstract

View Articletitled, Structure-based optimization of PKCθ inhibitors

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Sodium regulation of GAF domain function

M.J. Cann

Biochem Soc Trans (2007) 35 (5): 1032–1034.

Abstract

View Articletitled, Sodium regulation of GAF domain function

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Functional domains of the mouse β₃-adrenoceptor associated with differential G-protein coupling

M. Sato; D.S. Hutchinson; B.A. Evans; R.J. Summers

Biochem Soc Trans (2007) 35 (5): 1035–1037.

Abstract

View Articletitled, Functional domains of the mouse β3-adrenoceptor associated with differential G-protein coupling

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Study of the functional role of Bcl-2 family proteins in regulating Ca²⁺ signals in apoptotic cells

Y. Lao; D.C. Chang

Biochem Soc Trans (2007) 35 (5): 1038–1039.

Abstract

View Articletitled, Study of the functional role of Bcl-2 family proteins in regulating Ca2+ signals in apoptotic cells

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The roles of PKCδ and ϵ isoenzymes in the regulation of myocardial ischaemia/reperfusion injury

E.N. Churchill; D. Mochly-Rosen

Biochem Soc Trans (2007) 35 (5): 1040–1042.

Abstract

View Articletitled, The roles of PKCδ and ϵ isoenzymes in the regulation of myocardial ischaemia/reperfusion injury

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Lifespan regulation of conventional protein kinase C isotypes

D. Carmena; A. Sardini

Biochem Soc Trans (2007) 35 (5): 1043–1045.

Abstract

View Articletitled, Lifespan regulation of conventional protein kinase C isotypes

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The C2 domains of classical/conventional PKCs are specific PtdIns(4,5)P₂-sensing domains

S. Corbalán-García; M. Guerrero-Valero; C. Marín-Vicente; J.C. Gómez-Fernández

Biochem Soc Trans (2007) 35 (5): 1046–1048.

Abstract

View Articletitled, The C2 domains of classical/conventional PKCs are specific PtdIns(4,5)P2-sensing domains

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Aldosterone-stimulated PKC signalling cascades: from receptor to effector

W. Thomas; V. McEneaney; B.J. Harvey

Biochem Soc Trans (2007) 35 (5): 1049–1051.

Abstract

View Articletitled, Aldosterone-stimulated PKC signalling cascades: from receptor to effector

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Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage

G.R. Budas; D. Mochly-Rosen

Biochem Soc Trans (2007) 35 (5): 1052–1054.

Abstract

View Articletitled, Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage

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Ion Channel

Trafficking of ATP-sensitive potassium channels in health and disease

A. Sivaprasadarao; T.K. Taneja; J. Mankouri; A.J. Smith

Biochem Soc Trans (2007) 35 (5): 1055–1059.

Abstract

View Articletitled, Trafficking of ATP-sensitive potassium channels in health and disease

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hERG channel trafficking: novel targets in drug-induced long QT syndrome

A. Dennis; L. Wang; X. Wan; E. Ficker

Biochem Soc Trans (2007) 35 (5): 1060–1063.

Abstract

View Articletitled, hERG channel trafficking: novel targets in drug-induced long QT syndrome

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Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation

D.P. Mohapatra; K.-S. Park; J.S. Trimmer

Biochem Soc Trans (2007) 35 (5): 1064–1068.

Abstract

View Articletitled, Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation

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Localization and trafficking of cardiac voltage-gated potassium channels

D.F. Steele; A. Dehghani Zadeh; M.E. Loewen; D. Fedida

Biochem Soc Trans (2007) 35 (5): 1069–1073.

Abstract

View Articletitled, Localization and trafficking of cardiac voltage-gated potassium channels

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The role of abnormal trafficking of KCNE1 in long QT syndrome 5

S.C. Harmer; A. Tinker

Biochem Soc Trans (2007) 35 (5): 1074–1076.

Abstract

View Articletitled, The role of abnormal trafficking of KCNE1 in long QT syndrome 5

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Ion channels in epilepsy

S.M. Mizielinska

Biochem Soc Trans (2007) 35 (5): 1077–1079.

Abstract

View Articletitled, Ion channels in epilepsy

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Voltage clamp fluorimetry studies of mammalian voltage-gated K⁺ channel gating

T.W. Claydon; D. Fedida

Biochem Soc Trans (2007) 35 (5): 1080–1082.

Abstract

View Articletitled, Voltage clamp fluorimetry studies of mammalian voltage-gated K+ channel gating

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Inflammation

Phagosomal acidification: measurement, manipulation and functional consequences

B.E. Steinberg; K.K. Huynh; S. Grinstein

Biochem Soc Trans (2007) 35 (5): 1083–1087.

Abstract

View Articletitled, Phagosomal acidification: measurement, manipulation and functional consequences

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The role of calcium and other ions in sorting and delivery in the late endocytic pathway

J.P. Luzio; N.A. Bright; P.R. Pryor

Biochem Soc Trans (2007) 35 (5): 1088–1091.

Abstract

View Articletitled, The role of calcium and other ions in sorting and delivery in the late endocytic pathway

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The V-ATPase a2-subunit as a putative endosomal pH-sensor

V. Marshansky

Biochem Soc Trans (2007) 35 (5): 1092–1099.

Abstract

View Articletitled, The V-ATPase a2-subunit as a putative endosomal pH-sensor

Supplementary data

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The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs

P. Behe; A.W. Segal

Biochem Soc Trans (2007) 35 (5): 1100–1103.

Abstract

View Articletitled, The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs

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Defining a role for platelets in allergic inflammation

S.C. Pitchford

Biochem Soc Trans (2007) 35 (5): 1104–1108.

Abstract

View Articletitled, Defining a role for platelets in allergic inflammation

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Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase

J.S. Oak; M.P. Matheu; I. Parker; M.D. Cahalan; D.A. Fruman

Biochem Soc Trans (2007) 35 (5): 1109–1113.

Abstract

View Articletitled, Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase

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Regulation of T-cell migration by co-stimulatory molecules

R. David; F.M. Marelli-Berg

Biochem Soc Trans (2007) 35 (5): 1114–1118.

Abstract

View Articletitled, Regulation of T-cell migration by co-stimulatory molecules

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Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

G.C. Brown

Biochem Soc Trans (2007) 35 (5): 1119–1121.

Abstract

View Articletitled, Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

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Interleukin-1 and inflammatory neurodegeneration

A. Simi; N. Tsakiri; P. Wang; N.J. Rothwell

Biochem Soc Trans (2007) 35 (5): 1122–1126.

Abstract

View Articletitled, Interleukin-1 and inflammatory neurodegeneration

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Chronic microglial activation and progressive dopaminergic neurotoxicity

M.L. Block; J.-S. Hong

Biochem Soc Trans (2007) 35 (5): 1127–1132.

Abstract

View Articletitled, Chronic microglial activation and progressive dopaminergic neurotoxicity

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Nitric oxide, ischaemia and brain inflammation

S. Murphy; C.L. Gibson

Biochem Soc Trans (2007) 35 (5): 1133–1137.

Abstract

View Articletitled, Nitric oxide, ischaemia and brain inflammation

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An overview of the biological significance of endogenous gases: new roles for old molecules

L. Li; P.K. Moore

Biochem Soc Trans (2007) 35 (5): 1138–1141.

Abstract

View Articletitled, An overview of the biological significance of endogenous gases: new roles for old molecules

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Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities

R. Motterlini

Biochem Soc Trans (2007) 35 (5): 1142–1146.

Abstract

View Articletitled, Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities

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Biochemistry of oxidative stress

B. Halliwell

Biochem Soc Trans (2007) 35 (5): 1147–1150.

Abstract

View Articletitled, Biochemistry of oxidative stress

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Redox regulation of lung inflammation: role of NADPH oxidase and NF-κB signalling

H. Yao; S.-R. Yang; A. Kode; S. Rajendrasozhan; S. Caito; D. Adenuga; R. Henry; I. Edirisinghe; I. Rahman

Biochem Soc Trans (2007) 35 (5): 1151–1155.

Abstract

View Articletitled, Redox regulation of lung inflammation: role of NADPH oxidase and NF-κB signalling

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Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications

C. Alarcón de la Lastra; I. Villegas

Biochem Soc Trans (2007) 35 (5): 1156–1160.

Abstract

View Articletitled, Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications

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Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

H.M. McGettrick; A. Filer; G.E. Rainger; C.D. Buckley; G.B. Nash

Biochem Soc Trans (2007) 35 (5): 1161–1162.

Abstract

View Articletitled, Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

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Systemic inflammation and stroke: aetiology, pathology and targets for therapy

B.W. McColl; S.M. Allan; N.J. Rothwell

Biochem Soc Trans (2007) 35 (5): 1163–1165.

Abstract

View Articletitled, Systemic inflammation and stroke: aetiology, pathology and targets for therapy

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Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system

J.J. Neher; G.C. Brown

Biochem Soc Trans (2007) 35 (5): 1166–1167.

Abstract

View Articletitled, Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system

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P2X₇ receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators

J. Hewinson; A.B. MacKenzie

Biochem Soc Trans (2007) 35 (5): 1168–1170.

Abstract

View Articletitled, P2X7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators

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Metabolism

Insulin action on the liver in vivo

A.D. Cherrington; M.C. Moore; D.K. Sindelar; D.S. Edgerton

Biochem Soc Trans (2007) 35 (5): 1171–1174.

Abstract

View Articletitled, Insulin action on the liver in vivo

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Homocysteine metabolism in diabetes

E.P. Wijekoon; M.E. Brosnan; J.T. Brosnan

Biochem Soc Trans (2007) 35 (5): 1175–1179.

Abstract

View Articletitled, Homocysteine metabolism in diabetes

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Amino acid metabolism, insulin secretion and diabetes

P. Newsholme; K. Bender; A. Kiely; L. Brennan

Biochem Soc Trans (2007) 35 (5): 1180–1186.

Abstract

View Articletitled, Amino acid metabolism, insulin secretion and diabetes

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Amino acids and mTOR signalling in anabolic function

C.G. Proud

Biochem Soc Trans (2007) 35 (5): 1187–1190.

Abstract

View Articletitled, Amino acids and mTOR signalling in anabolic function

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Intestinal glucose sensing and regulation of intestinal glucose absorption

J. Dyer; K. Daly; K.S.H. Salmon; D.K. Arora; Z. Kokrashvili; R.F. Margolskee; S.P. Shirazi-Beechey

Biochem Soc Trans (2007) 35 (5): 1191–1194.

Abstract

View Articletitled, Intestinal glucose sensing and regulation of intestinal glucose absorption

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Physiological significance of L-amino acid sensing by extracellular Ca²⁺-sensing receptors

A.D. Conigrave; H.-C. Mun; S.C. Brennan

Biochem Soc Trans (2007) 35 (5): 1195–1198.

Abstract

View Articletitled, Physiological significance of L-amino acid sensing by extracellular Ca2+-sensing receptors

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Long-chain fatty acid sensing in the gastrointestinal tract

J. McLaughlin

Biochem Soc Trans (2007) 35 (5): 1199–1202.

Abstract

View Articletitled, Long-chain fatty acid sensing in the gastrointestinal tract

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Early life programming of energy balance

R.L. Cripps; Z.A. Archer; J.G. Mercer; S.E. Ozanne

Biochem Soc Trans (2007) 35 (5): 1203–1204.

Abstract

View Articletitled, Early life programming of energy balance

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PERK in the life and death of the pancreatic β-cell

T.P. Herbert

Biochem Soc Trans (2007) 35 (5): 1205–1207.

Abstract

View Articletitled, PERK in the life and death of the pancreatic β-cell

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Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells

D. Johnson; R.M. Shepherd; D. Gill; T. Gorman; D.M. Smith; M.J. Dunne

Biochem Soc Trans (2007) 35 (5): 1208–1210.

Abstract

View Articletitled, Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells

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Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation

K. Roder; M. Schweizer

Biochem Soc Trans (2007) 35 (5): 1211–1214.

Abstract

View Articletitled, Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation

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Amino acid transporters and nutrient-sensing mechanisms: new targets for treating insulin-linked disorders?

B. Reynolds; R. Laynes; M.H. Ögmundsdóttir; C.A.R. Boyd; D.C.I. Goberdhan

Biochem Soc Trans (2007) 35 (5): 1215–1217.

Abstract

View Articletitled, Amino acid transporters and nutrient-sensing mechanisms: new targets for treating insulin-linked disorders?

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Central Nervous System

Synaptic memory mechanisms: Alzheimer's disease amyloid β-peptide-induced dysfunction

M.J. Rowan; I. Klyubin; Q. Wang; N.W. Hu; R. Anwyl

Biochem Soc Trans (2007) 35 (5): 1219–1223.

Abstract

View Articletitled, Synaptic memory mechanisms: Alzheimer's disease amyloid β-peptide-induced dysfunction

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Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide

J.P. Bolaños; A. Herrero-Mendez; S. Fernandez-Fernandez; A. Almeida

Biochem Soc Trans (2007) 35 (5): 1224–1227.

Abstract

View Articletitled, Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide

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Mitochondrial dysfunction in neurodegenerative disorders

M. Baron; A.P. Kudin; W.S. Kunz

Biochem Soc Trans (2007) 35 (5): 1228–1231.

Abstract

View Articletitled, Mitochondrial dysfunction in neurodegenerative disorders

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Do mitochondrial DNA mutations have a role in neurodegenerative disease?

K.J. Krishnan; A.K. Reeve; D.M. Turnbull

Biochem Soc Trans (2007) 35 (5): 1232–1235.

Abstract

View Articletitled, Do mitochondrial DNA mutations have a role in neurodegenerative disease?

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Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons

C.H. Brown; V. Scott; M. Ludwig; G. Leng; C.W. Bourque

Biochem Soc Trans (2007) 35 (5): 1236–1242.

Abstract

View Articletitled, Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons

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The actin filament and dendritic peptide release

V.A. Tobin; M. Ludwig

Biochem Soc Trans (2007) 35 (5): 1243–1246.

Abstract

View Articletitled, The actin filament and dendritic peptide release

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Central release of oxytocin and the ventromedial hypothalamus

N. Sabatier; I. Rowe; G. Leng

Biochem Soc Trans (2007) 35 (5): 1247–1251.

Abstract

View Articletitled, Central release of oxytocin and the ventromedial hypothalamus

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Stimuli and consequences of dendritic release of oxytocin within the brain

I.D. Neumann

Biochem Soc Trans (2007) 35 (5): 1252–1257.

Abstract

View Articletitled, Stimuli and consequences of dendritic release of oxytocin within the brain

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Nitric oxide and respiratory rhythm in mammals: a new modulator of phase transition?

O. Pierrefiche; A.P.L. Abdala; J.F.R. Paton

Biochem Soc Trans (2007) 35 (5): 1258–1263.

Abstract

View Articletitled, Nitric oxide and respiratory rhythm in mammals: a new modulator of phase transition?

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Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing

G.L. Ackland; V. Kasymov; A.V. Gourine

Biochem Soc Trans (2007) 35 (5): 1264–1268.

Abstract

View Articletitled, Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing

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Respiratory plasticity following intermittent hypoxia: roles of protein phosphatases and reactive oxygen species

J.E.R. Wilkerson; P.M. MacFarlane; M.S. Hoffman; G.S. Mitchell

Biochem Soc Trans (2007) 35 (5): 1269–1272.

Abstract

View Articletitled, Respiratory plasticity following intermittent hypoxia: roles of protein phosphatases and reactive oxygen species

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Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors

B.D. Sachs; K. Akassoglou

Biochem Soc Trans (2007) 35 (5): 1273–1277.

Abstract

View Articletitled, Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors

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Liprin-α proteins: scaffold molecules for synapse maturation

S.A. Spangler; C.C. Hoogenraad

Biochem Soc Trans (2007) 35 (5): 1278–1282.

Abstract

View Articletitled, Liprin-α proteins: scaffold molecules for synapse maturation

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Dissecting DISC1 function through protein–protein interactions

N.J. Brandon

Biochem Soc Trans (2007) 35 (5): 1283–1286.

Abstract

View Articletitled, Dissecting DISC1 function through protein–protein interactions

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Neurotoxicity of tryptophan metabolites

A.J. Smith; T.W. Stone; R.A. Smith

Biochem Soc Trans (2007) 35 (5): 1287–1289.

Abstract

View Articletitled, Neurotoxicity of tryptophan metabolites

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How do mammalian mitochondria synthesize proteins?

J. Rorbach; R. Soleimanpour-Lichaei; R.N. Lightowlers; Z.M.A. Chrzanowska-Lightowlers

Biochem Soc Trans (2007) 35 (5): 1290–1291.

Abstract

View Articletitled, How do mammalian mitochondria synthesize proteins?

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Interaction of integrin β1 with cytokeratin 1 in neuroblastoma NMB7 cells

N.-N. Chuang; C.-C. Huang

Biochem Soc Trans (2007) 35 (5): 1292–1294.

Abstract

View Articletitled, Interaction of integrin β1 with cytokeratin 1 in neuroblastoma NMB7 cells

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Exercise

IL-6 signalling in exercise and disease

B.K. Pedersen

Biochem Soc Trans (2007) 35 (5): 1295–1297.

Abstract

View Articletitled, IL-6 signalling in exercise and disease

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The role of nutrition in stimulating muscle protein accretion at the molecular level

S.R. Kimball

Biochem Soc Trans (2007) 35 (5): 1298–1301.

Abstract

View Articletitled, The role of nutrition in stimulating muscle protein accretion at the molecular level

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Exercise- and nutrient-controlled mechanisms involved in maintenance of the musculoskeletal mass

M.J. Rennie

Biochem Soc Trans (2007) 35 (5): 1302–1305.

Abstract

View Articletitled, Exercise- and nutrient-controlled mechanisms involved in maintenance of the musculoskeletal mass

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Using systems biology to define the essential biological networks responsible for adaptation to endurance exercise training

P. Keller; N. Vollaard; J. Babraj; D. Ball; D.A. Sewell; J.A. Timmons

Biochem Soc Trans (2007) 35 (5): 1306–1309.

Abstract

View Articletitled, Using systems biology to define the essential biological networks responsible for adaptation to endurance exercise training

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Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways

T. Boonsong; L. Norton; K. Chokkalingam; K. Jewell; I. Macdonald; A. Bennett; K. Tsintzas

Biochem Soc Trans (2007) 35 (5): 1310–1311.

Abstract

View Articletitled, Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways

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Mechanotransduction in striated muscle via focal adhesion kinase

A.C. Durieux; D. Desplanches; D. Freyssenet; M. Flück

Biochem Soc Trans (2007) 35 (5): 1312–1313.

Abstract

View Articletitled, Mechanotransduction in striated muscle via focal adhesion kinase

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mVps34 is activated by an acute bout of resistance exercise

M.G. MacKenzie; D.L. Hamilton; J.T. Murray; K. Baar

Biochem Soc Trans (2007) 35 (5): 1314–1316.

Abstract

View Articletitled, mVps34 is activated by an acute bout of resistance exercise

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Bacteria

Tuberculosis: evolution in millennia and minutes

S.H. Gillespie

Biochem Soc Trans (2007) 35 (5): 1317–1320.

Abstract

View Articletitled, Tuberculosis: evolution in millennia and minutes

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Towards new tuberculosis drugs

S.T. Cole; P.M. Alzari

Biochem Soc Trans (2007) 35 (5): 1321–1324.

Abstract

View Articletitled, Towards new tuberculosis drugs

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Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets

L.J. Alderwick; H.L. Birch; A.K. Mishra; L. Eggeling; G.S. Besra

Biochem Soc Trans (2007) 35 (5): 1325–1328.

Abstract

View Articletitled, Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets

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Cancer

Mouse models for BRAF-induced cancers

C. Pritchard; L. Carragher; V. Aldridge; S. Giblett; H. Jin; C. Foster; C. Andreadi; T. Kamata

Biochem Soc Trans (2007) 35 (5): 1329–1333.

Abstract

View Articletitled, Mouse models for BRAF-induced cancers

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Conservation of DNA damage tolerance pathways from yeast to humans

H.D. Ulrich

Biochem Soc Trans (2007) 35 (5): 1334–1337.

Abstract

View Articletitled, Conservation of DNA damage tolerance pathways from yeast to humans

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Cancer genetics: mouse models of intestinal cancer

A.R. Clarke

Biochem Soc Trans (2007) 35 (5): 1338–1341.

Abstract

View Articletitled, Cancer genetics: mouse models of intestinal cancer

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Role played by BRCA1 in transcriptional regulation in response to therapy

M.M. Murray; P.B. Mullan; D.P. Harkin

Biochem Soc Trans (2007) 35 (5): 1342–1346.

Abstract

View Articletitled, Role played by BRCA1 in transcriptional regulation in response to therapy

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Characterization of cancer stem cells in chronic myeloid leukaemia

H.G. Jørgensen; T.L. Holyoake

Biochem Soc Trans (2007) 35 (5): 1347–1351.

Abstract

View Articletitled, Characterization of cancer stem cells in chronic myeloid leukaemia

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DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy

E. Petermann; T. Helleday

Biochem Soc Trans (2007) 35 (5): 1352–1354.

Abstract

View Articletitled, DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy

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Dietary meat, endogenous nitrosation and colorectal cancer

G.G.C. Kuhnle; S.A. Bingham

Biochem Soc Trans (2007) 35 (5): 1355–1357.

Abstract

View Articletitled, Dietary meat, endogenous nitrosation and colorectal cancer

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Determining the efficacy of dietary phytochemicals in cancer prevention

M.M. Manson; B.E. Foreman; L.M. Howells; E.P. Moiseeva

Biochem Soc Trans (2007) 35 (5): 1358–1363.

Abstract

View Articletitled, Determining the efficacy of dietary phytochemicals in cancer prevention

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Novel agents for cancer prevention based on nitric oxide

B. Rigas

Biochem Soc Trans (2007) 35 (5): 1364–1368.

Abstract

View Articletitled, Novel agents for cancer prevention based on nitric oxide

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Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?

B. Müller; J. Blackburn; C. Feijoo; X. Zhao; C. Smythe

Biochem Soc Trans (2007) 35 (5): 1369–1371.

Abstract

View Articletitled, Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?

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O-glycan regulation of apoptosis and proliferation in colorectal cancer cell lines

G. Patsos; C. Robbe-Masselot; A. Klein; V. Hebbe-Viton; R. San Martin; D. Masselot; M. Graessmann; C. Paraskeva; T. Gallagher; A. Corfield

Biochem Soc Trans (2007) 35 (5): 1372–1374.

Abstract

View Articletitled, O-glycan regulation of apoptosis and proliferation in colorectal cancer cell lines

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Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10^−/−) mice

R. Zhang; Y. Li; P.L. Beck; D.-M. McCafferty

Biochem Soc Trans (2007) 35 (5): 1375–1376.

Abstract

View Articletitled, Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10−/−) mice

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Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer

W.-B. Wu; H.-S. Chiang; J.-Y. Fang; C.-F. Hung

Biochem Soc Trans (2007) 35 (5): 1377–1378.

Abstract

View Articletitled, Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer

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