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August 2014
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ISSN 0300-5127
EISSN 1470-8752
In this Issue
Biochemical Society Awards
GlaxoSmithKline Award Lecture
Biochemical Society Focused Meetings
Signalling and Acquired Resistance to Targeted Cancer Therapeutics
Anticipating mechanisms of resistance to PI3K inhibition in breast cancer: a challenge in the era of precision medicine
Biochem Soc Trans (2014) 42 (4): 733–741.
Understanding life and death decisions in human leukaemias
David J. MacEwan; Lawrence N. Barrera; Sujitra Keadsanti; Stuart A. Rushworth; Niraj M. Shah; Tianma Yuan; Lyubov Zaitseva
Biochem Soc Trans (2014) 42 (4): 747–751.
Adaptive protein and phosphoprotein networks which promote therapeutic sensitivity or acquired resistance
Biochem Soc Trans (2014) 42 (4): 758–764.
Assessing adaptation of the cancer kinome in response to targeted therapies
Biochem Soc Trans (2014) 42 (4): 765–769.
Approaches for measuring signalling plasticity in the context of resistance to targeted cancer therapies
Biochem Soc Trans (2014) 42 (4): 791–797.
The role of the bone morphogenetic proteins in leukaemic stem cell persistence
Biochem Soc Trans (2014) 42 (4): 809–815.
One Hippo and many masters: differential regulation of the Hippo pathway in cancer
Biochem Soc Trans (2014) 42 (4): 816–821.
Exploring mechanisms of acquired resistance to HER2 (human epidermal growth factor receptor 2)-targeted therapies in breast cancer
Biochem Soc Trans (2014) 42 (4): 822–830.
A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy
Biochem Soc Trans (2014) 42 (4): 831–836.
Behaviour Meets Biochemistry: Animals Making Sense of Molecules Making Scents
The complexity of protein semiochemistry in mammals
Robert J. Beynon; Stuart D. Armstrong; Guadalupe Gómez-Baena; Victoria Lee; Deborah Simpson; Jennifer Unsworth; Jane L. Hurst
Biochem Soc Trans (2014) 42 (4): 837–845.
Vertebrate pheromones and other semiochemicals: the potential for accommodating complexity in signalling by volatile compounds for vertebrate management
Biochem Soc Trans (2014) 42 (4): 846–850.
Selection shaped the evolution of mouse androgen-binding protein (ABP) function and promoted the duplication of Abp genes
Biochem Soc Trans (2014) 42 (4): 851–860.
Comparative study of the molecular variation between ‘central’ and ‘peripheral’ MUPs and significance for behavioural signalling
Biochem Soc Trans (2014) 42 (4): 866–872.
Structure and function of a peptide pheromone family that stimulate the vomeronasal sensory system in mice
Biochem Soc Trans (2014) 42 (4): 873–877.
Female puberty acceleration by male odour in mice: neural pathway and behavioural consequences
Biochem Soc Trans (2014) 42 (4): 878–881.
Pheromone-induced cell proliferation in the murine subventricular zone
Biochem Soc Trans (2014) 42 (4): 882–885.
Complementary roles of mouse lipocalins in chemical communication and immunity
Biochem Soc Trans (2014) 42 (4): 893–898.
Redox Regulation in Health and Disease: a Celebration of 50 Years of the Keilin Memorial Lecture
The fission yeast Schizosaccharomyces pombe as a model to understand how peroxiredoxins influence cell responses to hydrogen peroxide
Biochem Soc Trans (2014) 42 (4): 909–916.
About the dangers, costs and benefits of living an aerobic lifestyle
Daniela Knoefler; Lars I.O. Leichert; Maike Thamsen; Claudia M. Cremers; Dana Reichmann; Michael J. Gray; Wei-Yun Wholey; Ursula Jakob
Biochem Soc Trans (2014) 42 (4): 917–921.
Thioredoxin as a putative biomarker and candidate target in age-related immune decline
Biochem Soc Trans (2014) 42 (4): 922–927.
Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?
Biochem Soc Trans (2014) 42 (4): 928–933.
Mitochondria and redox homoeostasis as chemotherapeutic targets
Biochem Soc Trans (2014) 42 (4): 939–944.
Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer
Biochem Soc Trans (2014) 42 (4): 945–951.
Mechanisms and physiological impact of the dual localization of mitochondrial intermembrane space proteins
Biochem Soc Trans (2014) 42 (4): 952–958.
Application of redox proteomics to skeletal muscle aging and exercise
Biochem Soc Trans (2014) 42 (4): 965–970.
Reassessing cellular glutathione homoeostasis: novel insights revealed by genetically encoded redox probes
Biochem Soc Trans (2014) 42 (4): 979–984.
Ultra-endurance exercise: unanswered questions in redox biology and immunology
Biochem Soc Trans (2014) 42 (4): 989–995.
The red blood cell: a new key player in cardiovascular homoeostasis? Focus on the nitric oxide pathway
Biochem Soc Trans (2014) 42 (4): 996–1000.
Hypercholesterolaemia-induced oxidative stress at the blood–brain barrier
Biochem Soc Trans (2014) 42 (4): 1001–1005.
Novel flavonoids as anti-cancer agents: mechanisms of action and promise for their potential application in breast cancer
Carlos Martinez-Perez; Carol Ward; Graeme Cook; Peter Mullen; Donald McPhail; David J. Harrison; Simon P. Langdon
Biochem Soc Trans (2014) 42 (4): 1017–1023.
Coenzyme A and Its Derivatives in Cellular Metabolism and Disease
Coenzyme A and its derivatives: renaissance of a textbook classic
Biochem Soc Trans (2014) 42 (4): 1025–1032.
Physiological roles of the pantothenate kinases
Lorraine E. Dansie; Stacy Reeves; Karen Miller; Stephen P. Zano; Matthew Frank; Caroline Pate; Jina Wang; Suzanne Jackowski
Biochem Soc Trans (2014) 42 (4): 1033–1036.
Protein acetylation as a means to regulate protein function in tune with metabolic state
Biochem Soc Trans (2014) 42 (4): 1037–1042.
Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation
Biochem Soc Trans (2014) 42 (4): 1043–1051.
Signalling functions of coenzyme A and its derivatives in mammalian cells
Biochem Soc Trans (2014) 42 (4): 1056–1062.
Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes
Biochem Soc Trans (2014) 42 (4): 1069–1074.
Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development
Biochem Soc Trans (2014) 42 (4): 1080–1086.
Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides
Biochem Soc Trans (2014) 42 (4): 1087–1093.
Intracellular redistribution of acetyl-CoA, the pivotal point in differential susceptibility of cholinergic neurons and glial cells to neurodegenerative signals
Andrzej Szutowicz; Hanna Bielarczyk; Anna Ronowska; Sylwia Gul-Hinc; Joanna Klimaszewska-Łata; Aleksandra Dyś; Marlena Zyśk; Tadeusz Pawełczyk
Biochem Soc Trans (2014) 42 (4): 1101–1106.
Independent Meetings
RNA UK 2014
Mechanisms of transcriptional dysregulation in repeat expansion disorders
Biochem Soc Trans (2014) 42 (4): 1123–1128.
Tra2 protein biology and mechanisms of splicing control
Andrew Best; Caroline Dalgliesh; Mahsa Kheirollahi-Kouhestani; Marina Danilenko; Ingrid Ehrmann; Alison Tyson-Capper; David J. Elliott
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Conflict RNA modification, host–parasite co-evolution, and the origins of DNA and DNA-binding proteins
Biochem Soc Trans (2014) 42 (4): 1159–1167.
Emerging functions of alternative splicing coupled with nonsense-mediated decay
Biochem Soc Trans (2014) 42 (4): 1168–1173.
Human genetic variation and its effect on miRNA biogenesis, activity and function
Biochem Soc Trans (2014) 42 (4): 1184–1189.
Single-molecule fluorescence-based studies on the dynamics, assembly and catalytic mechanism of the spliceosome
Biochem Soc Trans (2014) 42 (4): 1211–1218.
Acute kidney injury: a paradigm for miRNA regulation of the cell cycle
Biochem Soc Trans (2014) 42 (4): 1219–1223.
Recent studies implicate the nucleolus as the major site of nuclear translation
Biochem Soc Trans (2014) 42 (4): 1224–1228.
Poly(A)-binding proteins are required for diverse biological processes in metazoans
Biochem Soc Trans (2014) 42 (4): 1229–1237.
Yeast mRNA localization: protein asymmetry, organelle localization and response to stress
Biochem Soc Trans (2014) 42 (4): 1256–1260.