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Issues
August 2018
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Cover Image
Cover Image
The image represents a simplified ‘open’ cell of the gram-positive bacterium Streptomyces coelicolor and selected components of its zinc metabolism. The zinc sensor protein – zinc uptake regulator (Zur) – is shown in metallic blue in the middle, bound to DNA (green) where it works as a transcriptional repressor when zinc levels are adequate. The Zur-regulated high-affinity zinc uptake system ZnuABC is shown in purple. Synthesis of the secreted zincophore coelibactin is also Zur-regulated. Zinc ions are shown as silver balls surrounding the cell, and bound to Zur; for details see pages 983–1001.
The image has been created by Alevtina Mikhaylina with the help of Claudia A. Blindauer and David J. Scanlan.
ISSN 0300-5127
EISSN 1470-8752
In this Issue
Review Articles
O-linked mucin-type glycosylation in breast cancer
Joy M. Burchell; Richard Beatson; Rosalind Graham; Joyce Taylor-Papadimitriou; Virginia Tajadura-Ortega
Biochem Soc Trans (2018) 46 (4): 779–788.
The role of heparan sulfate in host macrophage infection by Leishmania species
Biochem Soc Trans (2018) 46 (4): 789–796.
Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?
Biochem Soc Trans (2018) 46 (4): 817–827.
Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention
Biochem Soc Trans (2018) 46 (4): 829–842.
Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?
Biochem Soc Trans (2018) 46 (4): 891–909.
Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease
Biochem Soc Trans (2018) 46 (4): 919–929.
Timing during translation matters: synonymous mutations in human pathologies influence protein folding and function
Biochem Soc Trans (2018) 46 (4): 937–944.
Bacterial zinc uptake regulator proteins and their regulons
Biochem Soc Trans (2018) 46 (4): 983–1001.
The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic
Victoria Casado-Medrano; Martin J. Baker; Cynthia Lopez-Haber; Mariana Cooke; Shaofei Wang; Maria J. Caloca; Marcelo G. Kazanietz
Biochem Soc Trans (2018) 46 (4): 1003–1012.
Editorials
CBMNet: the ‘Crossing Biological Membranes’ network in industrial biotechnology and bioenergy
Biochem Soc Trans (2018) 46 (4): 871–875.
