Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?
Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention
Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?
Timing during translation matters: synonymous mutations in human pathologies influence protein folding and function
The image represents a simplified ‘open’ cell of the gram-positive bacterium Streptomyces coelicolor and selected components of its zinc metabolism. The zinc sensor protein – zinc uptake regulator (Zur) – is shown in metallic blue in the middle, bound to DNA (green) where it works as a transcriptional repressor when zinc levels are adequate. The Zur-regulated high-affinity zinc uptake system ZnuABC is shown in purple. Synthesis of the secreted zincophore coelibactin is also Zur-regulated. Zinc ions are shown as silver balls surrounding the cell, and bound to Zur; for details see pages 983–1001.
The image has been created by Alevtina Mikhaylina with the help of Claudia A. Blindauer and David J. Scanlan.