Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments
The cover image illuminates the apicobasolateral uptake and transcytosis of degraded bone matrix from the ruffled border to the functional secretory domain in a polarized multinucleated bone-resorbing osteoclast. Magenta: nuclei, Green: cathepsin K/secretory lysosomes, Cyan: bone matrix, Red: F-actin cytoskeleton. For more information, see the article by Ng and colleagues (639–650) in this issue. Image courtesy of Nathan Pavlos.