Advances in the molecular regulation of endothelial BMP9 signalling complexes and implications for cardiovascular disease
How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers
Recent evidence has shown that, in addition to phosphorylation, Akt activity is allosterically coupled to the engagement of PI(3,4,5)P3 or PI(3,4)P2 in cellular membranes. The cover image shows the distribution of signalling phosphoinositides in the endomembranes of cells. For more information, see the article by Siess and Leonard (897–908) in this issue. Image courtesy of Thomas A. Leonard.