Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes
Use of S1QELs and S3QELs to link mitochondrial sites of superoxide and hydrogen peroxide generation to physiological and pathological outcomes
The cover image depicts immunofluorescence analysis of Multimerin-2 expression in the vessels of the gastric mucosa. Multimerin-2 is downregulated in various types of cancer. In this issue Mongiat and colleagues (1543–1565) discuss the role of the extracellular matrix as a gatekeeper, regulating tumour angiogenesis. Image courtesy of Maurizio Mongiat.