Editor-in-Chief: Professor Colin Bingle
Keywords: Genomics, innate immunity, host defence, respiratory, comparative biology, human disease, ciliogenesis
Biography: Colin is currently Professor of Respiratory Cell and Molecular Biology in the Department of Infection, Immunity and Cardiovascular Disease at the University of Sheffield. He has been at Sheffield since 1997. He graduated from the University of Bradford with a BSc in Medical Sciences and undertook his PhD at the Royal Free Hospital School of Medicines, submitting his thesis in 1989. Prior to his appointment at Sheffield, he undertook postdoctoral research at the University of London and at Washington University in St Louis, USA.
Affiliation: Universidade de São Paulo, Brazil
Keywords: Extracellular matrix, signalling pathways, mechanotransduction, cell biology, cell cycle, 3D-cell culture, fluorescence microscopy, CRISPR screens.
Biography: Alexandre is an Assistant Professor in the Department of Biochemistry at University of São Paulo – Brazil. His research group, the e-Signal Lab, focuses on understanding the mechanisms of transduction of biochemical and mechanical signals between cells and the extracellular matrix. For this, his laboratory uses 3D cell culture models, biochemistry tools, molecular biology and various microscopy techniques. Dr. Bruni-Cardoso holds a Bachelor's degree in Biological Sciences and a PhD in Cellular and Structural Biology. He did his postdoctoral studies in breast cancer biology in the laboratory of Dr. Mina J. Bissell at Lawrence Berkeley National Laboratory (USA).
Affiliation: Walter and Eliza Hall Institute of Medical Research, Australia
Keywords: Epigenetic silencing, genetic screens, epigenomics and transcriptomics, dosage compensation, chromatin conformation, mouse models
Biography: Marnie completed her PhD with Professor Emma Whitelaw (University of Sydney), and her postdoctoral studies with Professor Douglas Hilton (WEHI). In her post-doc she identified a critical role for the novel protein Smchd1 in X inactivation and studied the role of polycomb group proteins in haematopoietic stem cell function. In 2010, Marnie established her own group working on the molecular mechanisms of epigenetic control. She is now a joint division head of the Epigenetics and Development Division at WEHI and a Viertel Senior Medical Research Fellow.
Affiliation: Southern University of Science and Technology, China
Keywords: Plant, epigenetics, gene regulation, DNA methylation, histone modification, structural biology, biochemistry
Biography: Jiamu obtained his PhD degree from Shanghai Institutes of Biochemistry and Cell Biology, China, in 2008. After 5 years post-doc training at the Memorial Sloan-Kettering Cancer Center in New York, he established his own independent research group in the Shanghai Center for Plant Stress Biology, China, in 2014. In 2019, he moved to Southern University of Science and Technology as a full Professor. His laboratory mainly focuses on the structural and biochemical studies on plant epigenetics-related proteins and protein-nucleic acid complexes.
Affiliation: Oxford Brookes University, UK
Keywords: Metabolic modelling, metabolic control analysis, metabolic engineering, computational biology, enzyme kinetics
Biography: David is Emeritus Professor of Systems Biology at Oxford Brookes University where he has worked since 1973. His research began in enzymology and then moved into computer simulation and theoretical analysis of metabolic control. He pioneered developments in the analysis of the structure of metabolic networks (such as elementary modes analysis), and his computer modelling extended into signal transduction pathways and the cell cycle. Recent research includes genome-scale metabolic modelling of Arabidopsis, rice and several bacteria, and development of metabolic engineering strategies for plants, bioenergy and industrial biotechnology.
Affiliation: Walter and Eliza Hall Institute of Medical Research Australia
Keywords: Glycobiology, cell biology, human disease, protein expression, chemical synthesis, recombinant expression, drug discovery
Clare L. Hawkins
Affiliation: University of Copenhagen, Denmark
Keywords: Oxidative stress, redox biology, inflammation, atherosclerosis, cardiovascular disease, protein oxidation, analytical biochemistry, peroxidase, reactive oxygen species
Biography: Clare is a Professor with Special Responsibilities in Oxidant Biology at the University of Copenhagen, appointed in March 2017 after nearly 20 years in Sydney Australia, where she held the positions of Scientific Director and Group Leader at the Heart Research Institute (HRI), and Principal Research Fellow within the Faculty of Medicine, University of Sydney. She joined the HRI in 1997 as a postdoctoral fellow after the completion of her PhD at the University of York (UK). Her research focuses on understanding the fundamental mechanisms by which oxidative stress drives cellular damage and disease development during chronic inflammation.
James M Murphy
Affiliation: Walter and Eliza Hall Institute of Medical Research, Australia
Key words: Protein structure and function, protein kinases, pseudokinases, cell signalling, cell death
Biography: James is Head of the Inflammation Division at the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. He completed his PhD at the Australian National University in 2003 before undertaking postdoctoral training with Tony Pawson and Frank Sicheri at the Lunenfeld Institute (Toronto, Canada), then moving to Melbourne in 2007. He has pursued a mechanistic understanding of the roles of several pseudokinases, protein kinases, cytokines/receptors and epigenetic regulators in signal transduction, with a particular focus on MLKL, a key pseudokinase in the necroptosis cell death pathway. These studies have culminated in >100 publications to date.
Ivan Robert Nabi
Affiliation: University of British Columbia, Canada
Keywords: Cancer, cell biology, caveolin, galectin, Gp78, endoplasmic reticulum, membrane domains, ER-mitochondria contacts, super-resolution microscopy, tumour metastasis, focal adhesions, cell migration
Biography: Robert is Full Professor and Director of Imaging in the Life Sciences Institute of the University of British Columbia in Vancouver, Canada. He has over 20 years of experience in cancer cell biology and have published numerous research articles and reviews in the field of cellular domains and their role in cancer progression and metastasis. Recent work has focused on super-resolution microscopy, studying the nanodomain structure of the peripheral ER, defining distinct ER-mitochondria contact sites and applying computational machine learning approaches to single molecule localization microscopy to decipher the molecular structure of caveolae and scaffolds.
Affiliation: Oregon State University, USA
Keywords: Microtubule, motor proteins, kinesin, dynein, single-molecule microscopy, protein dynamics, mitosis
Biography: Weihong received his BSc in Physics in 1999 from Nankai Unversity (Tianjian, China) and his PhD in Biophysics in 2008 from The Ohio State University (Columbus, USA). Weihong performed his postdoctoral training at Harvard Medical School to study the mechanism and regulation of the microtubule motor protein dynein using single-molecule light microscopy before joining Oregon State University as an Assistant Professor of Physics in 2013. At Oregon State University, Weihong leads a research team to study the evolution, mechanism and regulation of kinesin motor proteins that are involved in mitosis.
Affiliation: University of Cambridge, UK
Keywords: Calcium signalling, ion channels, bioactive natural products, drug repurposing, rational drug design, structure and function of signalling proteins
Biography: Taufiq became interested in cell signalling while pursuing an MSc in Molecular Pharmacology in the University of Manchester in 2003. During his PhD (2005-2008) and postdoctoral fellowship period (2008-2011), he studied biophysical properties and regulatory aspects of some intracellular calcium channels at the Department of Pharmacology, University of Cambridge. In 2011, he received an Early Career Award in Signal Transduction from the Biochemical Society. In October 2012, he received a Royal Society University Research Fellowship and started his own research group in the same Department. Since 2016, he has been working as a University Lecturer in the same department.
Affiliation: Public Health Research Institute, Rutgers the State University of New Jersey and MORU Mahidol Oxford Tropical Medicine Research Unit, University of Oxford
Keywords: Bacterial cell biology, host-pathogen interactions, tropical medicine & global health, immunology & infectious disease
Biography: Jeanne is a Royal Society Dorothy Hodgkin Research Fellow at the University of Oxford and an Adjunct Assistant Professor at Rutgers University, running a research group based jointly in Bangkok, Thailand and New Jersey, USA. Her group studies the host-pathogen cell biology of the obligate intracellular bacterium Orientia tsutsugamushi and other rickettsial pathogens, especially those endemic in Southeast Asia. Jeanne studied biochemistry as an undergraduate at Oxford (2005), did her PhD at the MRC Laboratory of Molecular Biology in Cambridge, UK (2005-2010), then a postdoc at Harvard (2010-2012), before starting her own lab in 2013. She has since spent time as a visiting Professor at Rockefeller University (USA).
Affiliation: University of Glasgow, UK
Keywords: Ubiquitination, protein structure, ubiquitin ligases, Parkinson’s disease, Fanconi anaemia, enzyme structure-function
Biography: Helen obtained her BSc in Biochemistry from the University of Bath in 1998. She then moved to the University of St Andrews for her PhD, investigating the structural basis of protein hyperthermostability. In 2001, she moved to Memphis, Tennessee for a postdoc at St Jude's Children's Research Hospital. It was here that Helen developed her interest in the mechanisms of ubiquitination, solving the structure of the E1 for Nedd8. In 2005, Helen moved to the Lincoln's Inn Fields Laboratories of CRUK’s London Research Institute (now the Francis Crick Institute), to establish her own group. In 2015 Helen received the Colworth Medal from the Biochemical Society. After tenure, Helen moved to the MRC-Phosphorylation and Ubiquitylation Unit at the University of Dundee from 2013, and in 2017 relocated her laboratory to the University of Glasgow as Professor of Structural Biology.
Affiliation: University of Sheffield, UK
Keywords: Molecular biology, biotechnology, NMR, proteins, protein interactions, protein dynamics, structural biology, drug design
Biography: Mike did a PhD in Chemistry and has developed NMR methods for studying protein structure and interactions. He has been at the Department of Molecular Biology and Biotechnology at the University of Sheffield since 1990, where he is now Head of Department. He has published over 200 papers and two books (including a textbook, How Proteins Work).