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Editor-in-Chief: Professor Colin Bingle
Keywords: Genomics, innate immunity, host defence, respiratory, comparative biology, human disease, ciliogenesis
Biography: Colin is currently Professor of Respiratory Cell and Molecular Biology in the Department of Infection, Immunity and Cardiovascular Disease at the University of Sheffield. He has been at Sheffield since 1997. He graduated from the University of Bradford with a BSc in Medical Sciences and undertook his PhD at the Royal Free Hospital School of Medicines, submitting his thesis in 1989. Prior to his appointment at Sheffield, he undertook postdoctoral research at the University of London and at Washington University in St Louis, USA.
Keywords: Extracellular matrix, signalling pathways, mechanotransduction, cell biology, cell cycle, 3D-cell culture, fluorescence microscopy, CRISPR screens.
Biography: Alexandre is an Assistant Professor in the Department of Biochemistry at University of São Paulo – Brazil. His research group, the e-Signal Lab, focuses on understanding the mechanisms of transduction of biochemical and mechanical signals between cells and the extracellular matrix. For this, his laboratory uses 3D cell culture models, biochemistry tools, molecular biology and various microscopy techniques. Dr. Bruni-Cardoso holds a Bachelor's degree in Biological Sciences and a PhD in Cellular and Structural Biology. He did his postdoctoral studies in breast cancer biology in the laboratory of Dr. Mina J. Bissell at Lawrence Berkeley National Laboratory (USA).
Affiliation: Walter and Eliza Hall Institute of Medical Research, Australia
Keywords: Epigenetic silencing, genetic screens, epigenomics and transcriptomics, dosage compensation, chromatin conformation, mouse models
Biography: Marnie completed her PhD with Professor Emma Whitelaw (University of Sydney), and her postdoctoral studies with Professor Douglas Hilton (WEHI). In her post-doc she identified a critical role for the novel protein Smchd1 in X inactivation and studied the role of polycomb group proteins in haematopoietic stem cell function. In 2010, Marnie established her own group working on the molecular mechanisms of epigenetic control. She is now a joint division head of the Epigenetics and Development Division at WEHI and a Viertel Senior Medical Research Fellow.
Affiliation: Southern University of Science and Technology, China
Keywords: Plant, epigenetics, gene regulation, DNA methylation, histone modification, structural biology, biochemistry
Biography: Jiamu obtained his PhD degree from Shanghai Institutes of Biochemistry and Cell Biology, China, in 2008. After 5 years post-doc training at the Memorial Sloan-Kettering Cancer Center in New York, he established his own independent research group in the Shanghai Center for Plant Stress Biology, China, in 2014. In 2019, he moved to Southern University of Science and Technology as a full Professor. His laboratory mainly focuses on the structural and biochemical studies on plant epigenetics-related proteins and protein-nucleic acid complexes.
Affiliation: Oxford Brookes University, UK
Keywords: Metabolic modelling, metabolic control analysis, metabolic engineering, computational biology, enzyme kinetics
Biography: David is Emeritus Professor of Systems Biology at Oxford Brookes University where he has worked since 1973. His research began in enzymology and then moved into computer simulation and theoretical analysis of metabolic control. He pioneered developments in the analysis of the structure of metabolic networks (such as elementary modes analysis), and his computer modelling extended into signal transduction pathways and the cell cycle. Recent research includes genome-scale metabolic modelling of Arabidopsis, rice and several bacteria, and development of metabolic engineering strategies for plants, bioenergy and industrial biotechnology.
Affiliation: Walter and Eliza Hall Institute of Medical Research Australia
Keywords: Glycobiology, cell biology, human disease, protein expression, chemical synthesis, recombinant expression, drug discovery
Biography: Ethan leads a glycobiology-focussed research group within the Chemical Biology Division at the Walter and Eliza Hall Institute of Medical Research (WEHI), Australia. He completed his PhD at the University of Western Australia (2008) before conducting postdoctoral studies with Stephen Withers at the University of British Columbia (2009-2013) then establishing his own research group at WEHI (2013). His group harnesses chemical, biochemical and structural biology techniques to better understand how glycosylation impacts protein function in the context of immunological disorders, infectious diseases and cancer.
Clare L. Hawkins
Affiliation: University of Copenhagen, Denmark
Keywords: Oxidative stress, redox biology, inflammation, atherosclerosis, cardiovascular disease, protein oxidation, analytical biochemistry, peroxidase, reactive oxygen species
Biography: Clare is a Professor with Special Responsibilities in Oxidant Biology at the University of Copenhagen, appointed in March 2017 after nearly 20 years in Sydney Australia, where she held the positions of Scientific Director and Group Leader at the Heart Research Institute (HRI), and Principal Research Fellow within the Faculty of Medicine, University of Sydney. She joined the HRI in 1997 as a postdoctoral fellow after the completion of her PhD at the University of York (UK). Her research focuses on understanding the fundamental mechanisms by which oxidative stress drives cellular damage and disease development during chronic inflammation.
Sang Yup Lee
Affiliation: Korea Advanced Institute of Science and Technology (KAIST), South Korea
Keywords: Chemical biology, metabolic engineering, biochemical engineering, systems biology, synthetic biology, industrial biotechnology
Biography: Dr. Sang Yup Lee is Distinguished Professor at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST). He is currently the Dean of KAIST Institutes, Director of BioProcess Engineering Research Center, and Director of Bioinformatics Research Center. He has received numerous awards, including the National Order of Merit, National Science Medal, Ho-Am Prize, Merck Metabolic Engineering Award, Eni Award, and Samson Prime Minister’s Award. He is currently a Fellow of American Association for the Advancement of Science, American Academy of Microbiology, American Institute of Medical and Biological Engineering, Society for Industrial Microbiology and Biotechnology, the Korean Academy of Science and Technology, and National Academy of Engineering of Korea, amongst others. He is also foreign member of both National Academy of Sciences and National Academy of Engineering USA. His research areas are metabolic engineering, systems biology, synthetic biology, systems medicine, industrial biotechnology and nanobiotechnology.
James M Murphy
Affiliation: Walter and Eliza Hall Institute of Medical Research, Australia
Key words: Protein structure and function, protein kinases, pseudokinases, cell signalling, cell death
Biography: James is Head of the Inflammation Division at the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. He completed his PhD at the Australian National University in 2003 before undertaking postdoctoral training with Tony Pawson and Frank Sicheri at the Lunenfeld Institute (Toronto, Canada), then moving to Melbourne in 2007. He has pursued a mechanistic understanding of the roles of several pseudokinases, protein kinases, cytokines/receptors and epigenetic regulators in signal transduction, with a particular focus on MLKL, a key pseudokinase in the necroptosis cell death pathway. These studies have culminated in >100 publications to date.
Ivan Robert Nabi
Affiliation: University of British Columbia, Canada
Keywords: Cancer, cell biology, caveolin, galectin, Gp78, endoplasmic reticulum, membrane domains, ER-mitochondria contacts, super-resolution microscopy, tumour metastasis, focal adhesions, cell migration
Biography: Robert is Full Professor and Director of Imaging in the Life Sciences Institute of the University of British Columbia in Vancouver, Canada. He has over 20 years of experience in cancer cell biology and have published numerous research articles and reviews in the field of cellular domains and their role in cancer progression and metastasis. Recent work has focused on super-resolution microscopy, studying the nanodomain structure of the peripheral ER, defining distinct ER-mitochondria contact sites and applying computational machine learning approaches to single molecule localization microscopy to decipher the molecular structure of caveolae and scaffolds.
Affiliation: Swedish University of Agricultural Sciences, Sweden
Keywords: Nuclear structure, Transcription traffic control, RNA polymerases, Polycomb
Biography: Stefanie did her PhD in the laboratory of Prof. Peter Shaw (JIC, UK), where she questioned how the physical properties of chromatin change during cell differentiation. In 2013, she joined the lab of Prof. Caroline Dean (JIC, UK). During this time, she used live-cell imaging approaches and single-molecule RNA detection methods to study the importance of nuclear organization and long non-coding RNAs for transcriptional regulation. In 2018, Stefanie established her independent research group in the Department of Plant Biology (SLU, Uppsala - Sweden). There, she continues her focus on using single-molecule tools to study how the spatial-temporal organization of the chromatin affects regulatory processes at the level of transcription, but also how it impacts genome stability and DNA repair mechanisms in Arabidopsis thaliana.
Affiliation: Public Health Research Institute, Rutgers the State University of New Jersey and MORU Mahidol Oxford Tropical Medicine Research Unit, University of Oxford
Keywords: Bacterial cell biology, host-pathogen interactions, tropical medicine & global health, immunology & infectious disease
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Biography: Jeanne is a Royal Society Dorothy Hodgkin Research Fellow at the University of Oxford and an Adjunct Assistant Professor at Rutgers University, running a research group based jointly in Bangkok, Thailand and New Jersey, USA. Her group studies the host-pathogen cell biology of the obligate intracellular bacterium Orientia tsutsugamushi and other rickettsial pathogens, especially those endemic in Southeast Asia. Jeanne studied biochemistry as an undergraduate at Oxford (2005), did her PhD at the MRC Laboratory of Molecular Biology in Cambridge, UK (2005-2010), then a postdoc at Harvard (2010-2012), before starting her own lab in 2013. She has since spent time as a visiting Professor at Rockefeller University (USA).
Affiliation: University of Glasgow, UK
Keywords: Ubiquitination, protein structure, ubiquitin ligases, Parkinson’s disease, Fanconi anaemia, enzyme structure-function
Biography: Helen obtained her BSc in Biochemistry from the University of Bath in 1998. She then moved to the University of St Andrews for her PhD, investigating the structural basis of protein hyperthermostability. In 2001, she moved to Memphis, Tennessee for a postdoc at St Jude's Children's Research Hospital. It was here that Helen developed her interest in the mechanisms of ubiquitination, solving the structure of the E1 for Nedd8. In 2005, Helen moved to the Lincoln's Inn Fields Laboratories of CRUK’s London Research Institute (now the Francis Crick Institute), to establish her own group. In 2015 Helen received the Colworth Medal from the Biochemical Society. After tenure, Helen moved to the MRC-Phosphorylation and Ubiquitylation Unit at the University of Dundee from 2013, and in 2017 relocated her laboratory to the University of Glasgow as Professor of Structural Biology.
Affiliation: University of Sheffield, UK
Keywords: Molecular biology, biotechnology, NMR, proteins, protein interactions, protein dynamics, structural biology, drug design
Biography: Mike did a PhD in Chemistry and has developed NMR methods for studying protein structure and interactions. He has been at the Department of Molecular Biology and Biotechnology at the University of Sheffield since 1990, where he is now Head of Department. He has published over 200 papers and two books (including a textbook, How Proteins Work).