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GRAEME MILLIGAN
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Articles

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells

Peter Burton, David R. Adams, Achamma Abraham, Robert W. Allcock, Zhong Jiang, Angela McCahill, Jane Gilmour, John McAbney, Nicole M. Kane, George S. Baillie, Fergus R. McKenzie, Andrew H. Baker, Miles D. Houslay, Joanne C. Mountford, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1058–1061.
https://doi.org/10.1042/BST0381058
Published: 26 July 2010
View articletitled, Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells
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Articles

Construction and Analysis of α2A-Adrenoceptor G i /G o α-Subunit Fusion Proteins

Richard Ward, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (3): A115.
https://doi.org/10.1042/bst027a115
Published: 01 June 1999
View articletitled, Construction and Analysis of α2A-Adrenoceptor G i /G o α-Subunit Fusion Proteins
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Articles

Characterisation of Three Subtypes of Rat Thyrotropin Releasing Hormone Receptor

Tomas Drmota, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (3): A115.
https://doi.org/10.1042/bst027a115b
Published: 01 June 1999
View articletitled, Characterisation of Three Subtypes of Rat Thyrotropin Releasing Hormone Receptor
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Articles

Activation and Desensitisation of the Thyrotropin-Releasing Hormone Receptor Visualised by Monitoring Cellular Redistribution of a β-arrestin-1-Green Fluorescent Protein Fusion Protein

Alex Groarke, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (3): A118.
https://doi.org/10.1042/bst027a118c
Published: 01 June 1999
View articletitled, Activation and Desensitisation of the Thyrotropin-Releasing Hormone Receptor Visualised by Monitoring Cellular Redistribution of a β-arrestin-1-Green Fluorescent Protein Fusion Protein
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Articles

Internalisation of Wild type and Mutant α 1B -Adrenergic Receptors

Patricia A. Stevens, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (3): A114.
https://doi.org/10.1042/bst027a114
Published: 01 June 1999
View articletitled, Internalisation of Wild type and Mutant α 1B -Adrenergic Receptors
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Articles

Receptor-GFP Fusion Proteins; A study of Drug Effects on Receptor Internalisation, Trafficking and Expression

Alison J. McLean, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (3): A114.
https://doi.org/10.1042/bst027a114a
Published: 01 June 1999
View articletitled, Receptor-GFP Fusion Proteins; A study of Drug Effects on Receptor Internalisation, Trafficking and Expression
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Articles

G protein activation and effector regulation by the human 5-HT 1A receptor and the α subunit of G i1 fusion proteins

Elaine Kellett, I. Craig Carr, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (3): A114.
https://doi.org/10.1042/bst027a114b
Published: 01 June 1999
View articletitled, G protein activation and effector regulation by the human 5-HT 1A receptor and the α subunit of G i1 fusion proteins
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Articles

Cell Cycle Regulation in Rat 1 Fibroblasts Expressing a Murine Delta Opioid Gi Linked Receptor

Moira A. Wilson, Neil G. Anderson, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (3): A114.
https://doi.org/10.1042/bst027a114c
Published: 01 June 1999
View articletitled, Cell Cycle Regulation in Rat 1 Fibroblasts Expressing a Murine Delta Opioid Gi Linked Receptor
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Articles

Diversity in the signaling and regulation of G protein-coupled receptors

Graeme Milligan, D. Alex. Groake, Alison MacLean, Richard Ward, Chee Wai Fong, Antonella Cavalli, Tomas Drmota
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (1): A24.
https://doi.org/10.1042/bst027a024c
Published: 01 February 1999
View articletitled, Diversity in the signaling and regulation of G protein-coupled receptors
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Articles

Go1 α palmitoylation: Its contribution to α2C10 adrenoceptor - Go1α coupling

MORAG A. GRASSIE, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (3): 406S.
https://doi.org/10.1042/bst023406s
Published: 01 August 1995
View articletitled, Go1 α palmitoylation: Its contribution to α2C10 adrenoceptor - Go1α coupling
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Articles

Agonist regulation of high affinity [ 3 H] forskolin binding as a measure of G s α- adenylyl cyclase interactions

GUN DO KIM, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 8S.
https://doi.org/10.1042/bst023008s
Published: 01 February 1995
View articletitled, Agonist regulation of high affinity [ 3 H] forskolin binding as a measure of G s α- adenylyl cyclase interactions
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Articles

Palmitoylation negative mutants of murine G 11 α have decreased ability to interact with the plasma membrane when expressed in COS-1 cells

J. FRASER McCALLUM, ALAN WISE, MARCO PARENTI, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 9S.
https://doi.org/10.1042/bst023009s
Published: 01 February 1995
View articletitled, Palmitoylation negative mutants of murine G 11 α have decreased ability to interact with the plasma membrane when expressed in COS-1 cells
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Articles

Interaction of the β2-adrenoceptor with epitope-tagged G s αin NG108-15 cells

IAN MULLANEY, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 7S.
https://doi.org/10.1042/bst023007s
Published: 01 February 1995
View articletitled, Interaction of the β2-adrenoceptor with epitope-tagged G s αin NG108-15 cells
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Articles

High level expression of mammalian G protein α subunit Gq subtypes in Escherichia coli

Alan Wise, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 12S.
https://doi.org/10.1042/bst023012s
Published: 01 February 1995
View articletitled, High level expression of mammalian G protein α subunit Gq subtypes in Escherichia coli
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Articles

Cyclic AMP differentially regulates the expression of the α-subunits of G s , G q and G 11 G-proteins and their mRNA levels in rat C6 glioma cells

BUKHTIAR H. SHAH, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 10S.
https://doi.org/10.1042/bst023010s
Published: 01 February 1995
View articletitled, Cyclic AMP differentially regulates the expression of the α-subunits of G s , G q and G 11 G-proteins and their mRNA levels in rat C6 glioma cells
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Articles

Signalling characteristics of thyrotropin releasing hormone (TRH) receptor isoforms

TAE WEON LEE, KARIN A. EIDNE, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 11S.
https://doi.org/10.1042/bst023011s
Published: 01 February 1995
View articletitled, Signalling characteristics of thyrotropin releasing hormone (TRH) receptor isoforms
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Articles

Agonist activation of transfected human M1 muscarinic acetylcholine receptor in Chinese hamster ovary cells results in concurrent downregulation of Gqα and G11α

IAN MULLANEY, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (4): 497S.
https://doi.org/10.1042/bst021497s
Published: 01 November 1993
View articletitled, Agonist activation of transfected human M1 muscarinic acetylcholine receptor in Chinese hamster ovary cells results in concurrent downregulation of Gqα and G11α
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Articles

Activation of the gonadotropin releasing hormone receptor of αT3 cells results in downregulation of the α subunits of both Gq/G11

BUKHTIAR H. SHAH, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (4): 498S.
https://doi.org/10.1042/bst021498s
Published: 01 November 1993
View articletitled, Activation of the gonadotropin releasing hormone receptor of αT3 cells results in downregulation of the α subunits of both Gq/G11
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Articles

Lack of N terminal palmitoylation of G protein α sub-units reduces membrane association

MORAG A. GRASSIE, J. FRASER McCALLUM, MARCO PARENTI, ANTHONY I. MAGEE, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (4): 499S.
https://doi.org/10.1042/bst021499s
Published: 01 November 1993
View articletitled, Lack of N terminal palmitoylation of G protein α sub-units reduces membrane association
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Articles

Agonist regulation of cellular levels of the stimulatory guanine nucleotide-binding protein, G s , in wild type and transfected neuroblastoma-glioma hybrid NG108-15 cells

Elaine J. Adie, Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (2): 432–435.
https://doi.org/10.1042/bst0210432
Published: 01 May 1993
View articletitled, Agonist regulation of cellular levels of the stimulatory guanine nucleotide-binding protein, G s , in wild type and transfected neuroblastoma-glioma hybrid NG108-15 cells
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Articles

Multiple heterotrimeric guanine nucleotide binding proteins: roles in the determination of cellular signalling specificity

Graeme Milligan
Journal: Biochemical Society Transactions
Biochem Soc Trans (1992) 20 (1): 135–140.
https://doi.org/10.1042/bst0200135
Published: 01 February 1992
View articletitled, Multiple heterotrimeric guanine nucleotide binding proteins: roles in the determination of cellular signalling specificity
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Articles

Prostanoid-mediated downregulation of G s in NG108–15 cells

FERGUS R. McKENZIE, ELAINE J. ADIE, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1991) 19 (2): 81S.
https://doi.org/10.1042/bst019081s
Published: 01 April 1991
View articletitled, Prostanoid-mediated downregulation of G s in NG108–15 cells
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Articles

Effects of prolonged treatment of adipocytes with PGE 1 , N 6 -phenylisopropyl adenosine and nicotinic acid on G-proteins and antilipolytic sensitivity

ALLAN GREEN, GRAEME MILLIGAN, SUSAN E. BELT
Journal: Biochemical Society Transactions
Biochem Soc Trans (1991) 19 (2): 212S.
https://doi.org/10.1042/bst019212s
Published: 01 April 1991
View articletitled, Effects of prolonged treatment of adipocytes with PGE 1 , N 6 -phenylisopropyl adenosine and nicotinic acid on G-proteins and antilipolytic sensitivity
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Articles

U937 cell differentiation: G protein alterations and interaction with the chemotactic peptide receptor

FIONA M. MITCHELL, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1991) 19 (2): 98S.
https://doi.org/10.1042/bst019098s
Published: 01 April 1991
View articletitled, U937 cell differentiation: G protein alterations and interaction with the chemotactic peptide receptor
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Articles

Signal transduction in Rat-1 fibroblasts expressing high levels of the α2-C10 adrenergic receptor

GRAEME MILLIGAN, ELISABETH E. MacNULTY, STEVEN J. McCLUE, MICHAEL J.O. WAKELAM
Journal: Biochemical Society Transactions
Biochem Soc Trans (1991) 19 (2): 102S.
https://doi.org/10.1042/bst019102s
Published: 01 April 1991
View articletitled, Signal transduction in Rat-1 fibroblasts expressing high levels of the α2-C10 adrenergic receptor
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Articles

Identification and analysis of two distinct isoforms of the guanine nucleotide-binding protein G 0 in NG108-15 cells

IAN MULLANEY, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1990) 18 (3): 396–399.
https://doi.org/10.1042/bst0180396
Published: 01 June 1990
View articletitled, Identification and analysis of two distinct isoforms of the guanine nucleotide-binding protein G 0 in NG108-15 cells
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Articles

Down-regulation of the α-subunits of G i subtypes by prolonged incubation of adipocytes with N 6 -phenylisopropyl adenosine

ALLAN GREEN, JEFF L. JOHNSON, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1990) 18 (3): 487.
https://doi.org/10.1042/bst0180487
Published: 01 June 1990
View articletitled, Down-regulation of the α-subunits of G i subtypes by prolonged incubation of adipocytes with N 6 -phenylisopropyl adenosine
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Articles

Expression of G-protein β-subunit in lean and obese Zucker rats and streptozotocin-induced diabetic and normal rats

NIGEL J. PYNE, GRAEME MILLIGAN, MILES D. HOUSLAY
Journal: Biochemical Society Transactions
Biochem Soc Trans (1989) 17 (4): 667–668.
https://doi.org/10.1042/bst0170667
Published: 01 August 1989
View articletitled, Expression of G-protein β-subunit in lean and obese Zucker rats and streptozotocin-induced diabetic and normal rats
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Articles

Guanine nucleotide regulatory proteins in insulin's action and in diabetes

MILES D. HOUSLAY, NIGEL J. PYNE, RICHARD M. O'BRIEN, KENNETH SIDDLE, DEREK STRASSHEIM, TIMOTHY PALMER, SANDRA SPENCE, MARY WOODS, ANDREW WILSON, BRIAN LAVAN, GREGORY J. MURPHY, MARK SAVILLE, MARY-ANNE McGREGOR, ELAINE KILGOUR, NEIL ANDERSON, JOHN T. KNOWLER, SUSANNE GRIFFITHS, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1989) 17 (4): 627–629.
https://doi.org/10.1042/bst0170627
Published: 01 August 1989
View articletitled, Guanine nucleotide regulatory proteins in insulin's action and in diabetes
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Articles

The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins

FERGUS R. McKENZIE, IAN MULLANEY, CECILIA G. UNSON, ALLEN M. SPIEGEL, GRAEME MILLIGAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1988) 16 (4): 434–437.
https://doi.org/10.1042/bst0160434
Published: 01 August 1988
View articletitled, The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins
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Articles

The use of specific antibodies to identify and quantify guanine nucleotide-binding proteins

GRAEME MILLIGAN, PETER GIERSCHIK, ALLEN M. SPIEGEL
Journal: Biochemical Society Transactions
Biochem Soc Trans (1987) 15 (1): 42–45.
https://doi.org/10.1042/bst0150042
Published: 01 February 1987
View articletitled, The use of specific antibodies to identify and quantify guanine nucleotide-binding proteins
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Articles

The use of lipophilic anions to facilitate uptake of triphenylmethylphosphonium cation in membrane-potential studies in neuroblastoma cells

GRAEME MILLIGAN, PHILIP G. STRANGE
Journal: Biochemical Society Transactions
Biochem Soc Trans (1982) 10 (5): 375–376.
https://doi.org/10.1042/bst0100375
Published: 01 October 1982
View articletitled, The use of lipophilic anions to facilitate uptake of triphenylmethylphosphonium cation in membrane-potential studies in neuroblastoma cells
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Articles

Biochemical estimation of membrane potential in neuroblastoma cells

GRAEME MILLIGAN, PHILIP G. STRANGE
Journal: Biochemical Society Transactions
Biochem Soc Trans (1981) 9 (5): 414–415.
https://doi.org/10.1042/bst0090414
Published: 01 October 1981
View articletitled, Biochemical estimation of membrane potential in neuroblastoma cells
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