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ROBERT B. FREEDMAN
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Articles

Purification and characterisation of a novel extracellular lipase from Xanthomonas maltophila

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ANDREW D. HOOKER, ROBERT B. FREEDMAN, KENNETH A. STACEY
Journal: Biochemical Society Transactions
Biochem Soc Trans (1997) 25 (1): 14S.
https://doi.org/10.1042/bst025014s
Published: 01 February 1997
View articletitled, Purification and characterisation of a novel extracellular lipase from Xanthomonas maltophila
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Articles

The glycosylation of human recombinant alpha-1-antitrypsin expressed in transgenic mice

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PAULINE A. KEMP, NIGEL JENKINS, A. JOHN CLARK, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1996) 24 (3): 339S.
https://doi.org/10.1042/bst024339s
Published: 01 August 1996
View articletitled, The glycosylation of human recombinant alpha-1-antitrypsin expressed in transgenic mice
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Articles

Protein disulphide isomerase (PDI) is required for the secretion of a native disulphide-bonded protein from Saccharomyces cerevisiae

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ANGELA DUNN, JOSÉ M LUZ, DESSY NATALIA, JOHN A GAMBLE, ROBERT B FREEDMAN, MICK F TUITE
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 78S.
https://doi.org/10.1042/bst023078s
Published: 01 February 1995
View articletitled, Protein disulphide isomerase (PDI) is required for the secretion of a native disulphide-bonded protein from Saccharomyces cerevisiae
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Articles

Expression of the pro-regions of papain and papaya proteinase IV in Escherichia coli and their inhibition of mature cysteine proteinases

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MARK A.J. TAYLOR, GEOFFREY S. BRIGGS, KENNETH C. BAKER, NICOLA J. CUMMINGS, KATHRYN A. PRATT, ROBERT B. FREEDMAN, PETER W. GOODENOUGH
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 80S.
https://doi.org/10.1042/bst023080s
Published: 01 February 1995
View articletitled, Expression of the pro-regions of papain and papaya proteinase IV in Escherichia coli and their inhibition of mature cysteine proteinases
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Articles

The in vitro catalysis of protein folding by endoplasmic reticulum luminal peptidyl prolyl cis-trans isomerase

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SUCHIRA BOSE, HAUKE LI LIE, JOHANNES BUCHNER, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 63S.
https://doi.org/10.1042/bst023063s
Published: 01 February 1995
View articletitled, The in vitro catalysis of protein folding by endoplasmic reticulum luminal peptidyl prolyl cis-trans isomerase
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Articles

Cloning and expression of Vibrio cholerae dsbA , a gene encoding a periplasmic protein disulphide isomerase

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EDWARD D. LOWE, ROBERT B. FREEDMAN, TIMOTHY R. HIRST, PETER T. BARTH
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 64S.
https://doi.org/10.1042/bst023064s
Published: 01 February 1995
View articletitled, Cloning and expression of Vibrio cholerae dsbA , a gene encoding a periplasmic protein disulphide isomerase
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Articles

Analysis of human interferon-γ glycoforms produced in baculovirus infected insect cells by matrix assisted laser desorption spectrometry

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OLOTU W. OGONAH, ROBERT B. FREEDMAN, NIGEL JENKINS, BARRIE C. ROONEY
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 100S.
https://doi.org/10.1042/bst023100s
Published: 01 February 1995
View articletitled, Analysis of human interferon-γ glycoforms produced in baculovirus infected insect cells by matrix assisted laser desorption spectrometry
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Articles

The effect of denaturants on PDI conformation and activity

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Hilary. C. Hawkins, Robert. B. Freedman
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 65S.
https://doi.org/10.1042/bst023065s
Published: 01 February 1995
View articletitled, The effect of denaturants on PDI conformation and activity
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Articles

Properties and cellular functions of related yeast ER proteins protein disulphrde-isomerase and Euglp

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PHILIP A. WEBSTER, DAVID PIOLI, MICK F. TUITE, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 66S.
https://doi.org/10.1042/bst023066s
Published: 01 February 1995
View articletitled, Properties and cellular functions of related yeast ER proteins protein disulphrde-isomerase and Euglp
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Articles

The chaperonins of Clostridium thermocellum

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STEPHEN J. CROSS, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 67S.
https://doi.org/10.1042/bst023067s
Published: 01 February 1995
View articletitled, The chaperonins of Clostridium thermocellum
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Articles

Refolding of the mixed disulphide of RNase T 1 and glutathione

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ROBERT B. FREEDMAN, MARGHERITA RUOPPOLO
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 68S.
https://doi.org/10.1042/bst023068s
Published: 01 February 1995
View articletitled, Refolding of the mixed disulphide of RNase T 1 and glutathione
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Articles

Cloning and expression of active domains of human protein disulphide isomerase

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STEPHEN H. McLAUGHLIN, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 69S.
https://doi.org/10.1042/bst023069s
Published: 01 February 1995
View articletitled, Cloning and expression of active domains of human protein disulphide isomerase
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Articles

The importance of water to biocatalysis in organic solvents

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Mark J. Alston, Robert B. Freedman
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 70S.
https://doi.org/10.1042/bst023070s
Published: 01 February 1995
View articletitled, The importance of water to biocatalysis in organic solvents
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Articles

Chemical modification of tissue inhibitor of metalloproteinases-1 (TIMP-1)

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RICHARD A. WILLIAMSON, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1992) 20 (3): 255S.
https://doi.org/10.1042/bst020255s
Published: 01 August 1992
View articletitled, Chemical modification of tissue inhibitor of metalloproteinases-1 (TIMP-1)
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Articles

The characterisation of peptidyl prolyl cis-trans isomerase (PPI) activity associated with the endoplasmic reticulum

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SUCHIRA BOSE, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1992) 20 (3): 256S.
https://doi.org/10.1042/bst020256s
Published: 01 August 1992
View articletitled, The characterisation of peptidyl prolyl cis-trans isomerase (PPI) activity associated with the endoplasmic reticulum
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Articles

Stability and unfolding studies on papain

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GEOFFREY S. BRIGGS, ROBERT B. FREEDMAN, PETER W. GOODENOUGH, IAN G. SUMNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1992) 20 (3): 257S.
https://doi.org/10.1042/bst020257s
Published: 01 August 1992
View articletitled, Stability and unfolding studies on papain
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Articles

Post-translational modification and folding of secreted proteins

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ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1989) 17 (2): 331–335.
https://doi.org/10.1042/bst0170331
Published: 01 April 1989
View articletitled, Post-translational modification and folding of secreted proteins
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Articles

Protein disulphide-isomerase: a homologue of thioredoxin implicated in the biosynthesis of secretory proteins

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ROBERT B. FREEDMAN, HILARY C. HAWKINS, SUSAN J. MURANT, LORNE REID
Journal: Biochemical Society Transactions
Biochem Soc Trans (1988) 16 (2): 96–99.
https://doi.org/10.1042/bst0160096
Published: 01 April 1988
View articletitled, Protein disulphide-isomerase: a homologue of thioredoxin implicated in the biosynthesis of secretory proteins
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Articles

Recovery, refolding and purification of recombinant α 2 -interferon

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MARK J. WILSON, ROBERT B. FREEDMAN, JOHN E. FITTON
Journal: Biochemical Society Transactions
Biochem Soc Trans (1988) 16 (1): 58–59.
https://doi.org/10.1042/bst0160058a
Published: 01 February 1988
View articletitled, Recovery, refolding and purification of recombinant α 2 -interferon
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Articles

Reversible and irreversible denaturation: rationale for a process for recovery of recombinant prochymosin

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RICHARD SUGRUE, ROBERT B. FREEDMAN, PETER A. LOWE, FIONA A. O. MARSTON
Journal: Biochemical Society Transactions
Biochem Soc Trans (1988) 16 (1): 59–60.
https://doi.org/10.1042/bst0160059
Published: 01 February 1988
View articletitled, Reversible and irreversible denaturation: rationale for a process for recovery of recombinant prochymosin
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Articles

Induction of protein disulphide-isomerase during lymphocyte activation and maturation

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JAN L. PAVER, ROBERT B. FREEDMAN, R. MICHAEL, E. PARKHOUSE
Journal: Biochemical Society Transactions
Biochem Soc Trans (1988) 16 (1): 56.
https://doi.org/10.1042/bst0160056
Published: 01 February 1988
View articletitled, Induction of protein disulphide-isomerase during lymphocyte activation and maturation
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Articles

Protein disulphide-isomerase activity in bacterial osmotic shock preparations

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PETER T. BARTH, CAROLINE BUST, HILARY C. HAWKINS, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1988) 16 (1): 57.
https://doi.org/10.1042/bst0160057
Published: 01 February 1988
View articletitled, Protein disulphide-isomerase activity in bacterial osmotic shock preparations
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Articles

Specific release of protein disulphide-isomerase from pancreatic microsomal membranes

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JAN L. PAVER, ROBERT B. FREEDMAN, MICHAEL HORTSCH, DAVID MEYER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1988) 16 (1): 58.
https://doi.org/10.1042/bst0160058
Published: 01 February 1988
View articletitled, Specific release of protein disulphide-isomerase from pancreatic microsomal membranes
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Articles

The active site of protein disulphide-isomerase: functional analogy to thioredoxin

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HILARY C. HAWKINS, SIMON J. FORSTER, SUSAN J. MURANT, MARK J. WILSON, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1986) 14 (4): 756–757.
https://doi.org/10.1042/bst0140756a
Published: 01 August 1986
View articletitled, The active site of protein disulphide-isomerase: functional analogy to thioredoxin
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Articles

Fluorescence studies on the conformation of authentic and recombinant prochymosin

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RICHARD SUGRUE, PETER A. LOWE, FIONA A. O. MARSTON, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1985) 13 (6): 1146.
https://doi.org/10.1042/bst0131146
Published: 01 December 1985
View articletitled, Fluorescence studies on the conformation of authentic and recombinant prochymosin
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Articles

Protein disulphide-isomerase activity of preparations used in the study of protein synthesis in vitro

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BARBARA E. BROCKWAY, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1984) 12 (6): 1041.
https://doi.org/10.1042/bst0121041
Published: 01 December 1984
View articletitled, Protein disulphide-isomerase activity of preparations used in the study of protein synthesis in vitro
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Articles

Protein disulphide-isomerase and the formation of native disulphide bonds

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ROBERT B. FREEDMAN, BARBARA E. BROCKWAY, LAMBERT NIGEL
Journal: Biochemical Society Transactions
Biochem Soc Trans (1984) 12 (6): 929–932.
https://doi.org/10.1042/bst0120929
Published: 01 December 1984
View articletitled, Protein disulphide-isomerase and the formation of native disulphide bonds
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Articles

Chemical modification of essential residues in purified rat liver protein disulphide-isomerase

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NIGEL LAMBERT, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1984) 12 (6): 1042.
https://doi.org/10.1042/bst0121042
Published: 01 December 1984
View articletitled, Chemical modification of essential residues in purified rat liver protein disulphide-isomerase
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Articles

Protein disulphide-isomerase of mature and developing wheat

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GRACIA M. V. DE AZEVEDO, BARBARA E. BROCKWAY, ROBERT B. FREEDMAN, PHILIP GREENWELL, LINDA T. RODEN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1984) 12 (6): 1043.
https://doi.org/10.1042/bst0121043
Published: 01 December 1984
View articletitled, Protein disulphide-isomerase of mature and developing wheat
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Articles

Modified procedure for rapid purification of protein disulphide-isomerase from bovine liver

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NIGEL LAMBERT, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1982) 10 (2): 113–114.
https://doi.org/10.1042/bst0100113a
Published: 01 April 1982
View articletitled, Modified procedure for rapid purification of protein disulphide-isomerase from bovine liver
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Articles

Protein disulphide-isomerase is distinct from the liver microsomal protein capable of inactivating cytosol enzymes by thiol: disulphide interchange

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ROBERT B. FREEDMAN, PAUL GARDEN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1982) 10 (2): 114–115.
https://doi.org/10.1042/bst0100114
Published: 01 April 1982
View articletitled, Protein disulphide-isomerase is distinct from the liver microsomal protein capable of inactivating cytosol enzymes by thiol: disulphide interchange
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Articles

The distribution of protein disulphide-isomerase activity in mammalian tissue

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BARBARA E. BROCKWAY, SIMON J. FOSTER, ROBERT B. FREEDMAN, DAVID A. HILLSON
Journal: Biochemical Society Transactions
Biochem Soc Trans (1982) 10 (2): 115–116.
https://doi.org/10.1042/bst0100115
Published: 01 April 1982
View articletitled, The distribution of protein disulphide-isomerase activity in mammalian tissue
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Articles

Disulphide-bond formation in protein folding catalysed by highly-purified protein disulphideisomerase

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ROBERT B. FREEDMAN, DAVID A. HILLSON, THOMAS E. CREIGHTON
Journal: Biochemical Society Transactions
Biochem Soc Trans (1981) 9 (1): 79–80.
https://doi.org/10.1042/bst0090079
Published: 01 February 1981
View articletitled, Disulphide-bond formation in protein folding catalysed by highly-purified protein disulphideisomerase
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Articles

Effect of temperature on cross-linking of cytochromes P -450 and microviscosity in rabbit liver microsomal membranes

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PETER R. McINTOSH, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1981) 9 (1): 141–142.
https://doi.org/10.1042/bst0090141
Published: 01 February 1981
View articletitled, Effect of temperature on cross-linking of cytochromes P -450 and microviscosity in rabbit liver microsomal membranes
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Articles

Resolution of Ox Liver Thiol-Disulphide Oxidoreductases by a New Application of Covalent Chromatography

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DAVID A. HILLSON, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1979) 7 (3): 573–574.
https://doi.org/10.1042/bst0070573
Published: 01 June 1979
View articletitled, Resolution of Ox Liver Thiol-Disulphide Oxidoreductases by a New Application of Covalent Chromatography
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Articles

Resolution of Microsomal Membrane Proteins by Two-Dimensional Gel Electrophoresis

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MUSTAKALI KADERBHAI, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1978) 6 (6): 1366–1369.
https://doi.org/10.1042/bst0061366
Published: 01 December 1978
View articletitled, Resolution of Microsomal Membrane Proteins by Two-Dimensional Gel Electrophoresis
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Articles

Modification in vitro by a Cross-Linking Reagent of Rabbit Liver Microsomal Proteins Induced by β-Naphthoflavone

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PETER R. McINTOSH, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1978) 6 (6): 1372–1375.
https://doi.org/10.1042/bst0061372
Published: 01 December 1978
View articletitled, Modification in vitro by a Cross-Linking Reagent of Rabbit Liver Microsomal Proteins Induced by β-Naphthoflavone
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Articles

Nitrated Ribonuclease in the Study of Protein Disulphide-Bond Formation and Interchange

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DAVID A. HILLSON, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1977) 5 (3): 686–689.
https://doi.org/10.1042/bst0050686
Published: 01 June 1977
View articletitled, Nitrated Ribonuclease in the Study of Protein Disulphide-Bond Formation and Interchange
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Articles

Enzyme-Catalysed Disulphide Interchange and Protein Biosynthesis

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ROBERT B. FREEDMAN, HILARY C. HAWKINS
Journal: Biochemical Society Transactions
Biochem Soc Trans (1977) 5 (1): 348–357.
https://doi.org/10.1042/bst0050348
Published: 01 February 1977
View articletitled, Enzyme-Catalysed Disulphide Interchange and Protein Biosynthesis
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Use of Gel Filtration to Monitor Ribosome-Membrane Interaction

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ALAN L. IBBETSON, ROBERT B. FREEDMAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (1975) 3 (1): 197–198.
https://doi.org/10.1042/bst0030197
Published: 01 February 1975
View articletitled, Use of Gel Filtration to Monitor Ribosome-Membrane Interaction
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