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Articles

Exploring the oncogenic roles of T-box transcription factor TBX2 and its potential as a therapeutic target

Claire Bellis, Mihlali V. Mlaza, Abid Ali, Amaal Abrahams, Sharon Prince

Biochem Soc Trans (2025) BST20241069.

https://doi.org/10.1042/BST20241069

Published: 06 February 2025

View article titled, Exploring the oncogenic roles of T-box transcription factor TBX2 and its potential as a therapeutic target

Articles

Exploring genome-transcriptome correlations in cancer

Michael Ronemus, Daniel Bradford, Zachary Laster, Siran Li

Biochem Soc Trans (2025) BST20240108.

https://doi.org/10.1042/BST20240108

Published: 05 February 2025

View article titled, Exploring genome-transcriptome correlations in cancer

Articles

Current understanding of heparanase 2 regulation, a non-heparanase

Yannic Becker, Hermann Haller

Biochem Soc Trans (2025) BST20241281.

https://doi.org/10.1042/BST20241281

Published: 05 February 2025

View article titled, Current understanding of heparanase 2 regulation, a non-heparanase

Articles

The integrin adhesome and control of anti-tumour immunity

Emily R. Webb, Annabel Black, Nicole D. Barth, Stefan N. Symeonides, Valerie G. Brunton

Biochem Soc Trans (2024) 52 (6): 2455–2468.

https://doi.org/10.1042/BST20240386

Published: 06 December 2024

View article titled, The integrin adhesome and control of anti-tumour immunity

Articles

Advances towards potential cancer therapeutics targeting Hippo signaling

Rui Zhu, Zhihan Jiao, Fa-Xing Yu

Biochem Soc Trans (2024) 52 (6): 2399–2413.

https://doi.org/10.1042/BST20240244

Published: 06 December 2024

View article titled, Advances towards potential cancer therapeutics targeting Hippo signaling

Articles

Using human disease mutations to understand de novo DNA methyltransferase function

Willow Rolls, Marcus D. Wilson, Duncan Sproul

Biochem Soc Trans (2024) 52 (5): 2059–2075.

https://doi.org/10.1042/BST20231017

Published: 24 October 2024

View article titled, Using human disease mutations to understand de novo DNA methyltransferase function

Articles

Histone H3 mutations and their impact on genome stability maintenance

Lucas D. Caeiro, Ramiro E. Verdun, Lluis Morey

Biochem Soc Trans (2024) 52 (5): 2179–2191.

https://doi.org/10.1042/BST20240177

Published: 09 September 2024

View article titled, Histone H3 mutations and their impact on genome stability maintenance

Articles

Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential

Addison A. Young, Holly E. Bohlin, Jackson R. Pierce, Kyle A. Cottrell

Biochem Soc Trans (2024) 52 (5): 2035–2045.

https://doi.org/10.1042/BST20230727

Published: 02 September 2024

View article titled, Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential

Articles

Discovery of telomerase inhibitors: existing strategies and emerging innovations

Lauren Kageler, Elisa Aquilanti

Biochem Soc Trans (2024) 52 (4): 1957–1968.

https://doi.org/10.1042/BST20230264

Published: 28 August 2024

View article titled, Discovery of telomerase inhibitors: existing strategies and emerging innovations

Articles

Structural biology of shelterin and telomeric chromatin: the pieces and an unfinished puzzle

Hongmiao Hu, Helen Linwen Yan, Thi Hoang Duong Nguyen

Biochem Soc Trans (2024) 52 (4): 1551–1564.

https://doi.org/10.1042/BST20230300

Published: 07 August 2024

View article titled, Structural biology of shelterin and telomeric chromatin: the pieces and an unfinished puzzle

Articles

Enzymes of sphingolipid metabolism as transducers of metabolic inputs

Fabiola N. Velazquez, Chiara Luberto, Daniel Canals, Yusuf A. Hannun

Biochem Soc Trans (2024) 52 (4): 1795–1808.

https://doi.org/10.1042/BST20231442

Published: 05 August 2024

View article titled, Enzymes of sphingolipid metabolism as transducers of metabolic inputs

Articles

Targeting endocytosis to sensitize cancer cells to programmed cell death

Emily T. Chan, Cömert Kural

Biochem Soc Trans (2024) 52 (4): 1703–1713.

https://doi.org/10.1042/BST20231332

Published: 02 August 2024

View article titled, Targeting endocytosis to sensitize cancer cells to programmed cell death

Articles

I told you to stop: obscurin's role in epithelial cell migration

Kamrin D. Shultz, Yasmin F. Al Anbari, Nathan T. Wright

Biochem Soc Trans (2024) 52 (4): 1947–1956.

https://doi.org/10.1042/BST20240564

Published: 25 July 2024

View article titled, I told you to stop: obscurin's role in epithelial cell migration

Articles

Do tunneling nanotubes drive chemoresistance in solid tumors and other malignancies?

Akshat Sarkari, Emil Lou

Biochem Soc Trans (2024) 52 (4): 1757–1764.

https://doi.org/10.1042/BST20231364

Published: 19 July 2024

View article titled, Do tunneling nanotubes drive chemoresistance in solid tumors and other malignancies?

Articles

Understanding P-Rex regulation: structural breakthroughs and emerging perspectives

Gareth D. Jones, Andrew M. Ellisdon

Biochem Soc Trans (2024) 52 (4): 1849–1860.

https://doi.org/10.1042/BST20231546

Published: 18 July 2024

View article titled, Understanding P-Rex regulation: structural breakthroughs and emerging perspectives

Articles

Making cups and rings: the ‘stalled-wave’ model for macropinocytosis

Robert R. Kay, Judith E. Lutton, Jason S. King, Till Bretschneider

Biochem Soc Trans (2024) 52 (4): 1785–1794.

https://doi.org/10.1042/BST20231426

Published: 27 June 2024

View article titled, Making cups and rings: the ‘stalled-wave’ model for macropinocytosis

Articles

Mechanoimmunology in the solid tumor microenvironment

Matteo Golo, Peter L. H. Newman, Daryan Kempe, Maté Biro

Biochem Soc Trans (2024) 52 (3): 1489–1502.

https://doi.org/10.1042/BST20231427

Published: 10 June 2024

View article titled, Mechanoimmunology in the solid tumor microenvironment

Articles

Computational single-cell methods for predicting cancer risk

Andrew E. Teschendorff

Biochem Soc Trans (2024) 52 (3): 1503–1514.

https://doi.org/10.1042/BST20231488

Published: 10 June 2024

View article titled, Computational single-cell methods for predicting cancer risk

Articles

Exploring the conformational landscapes of protein kinases: perspectives from FRET and DEER

Zachary D. Baker, Damien M. Rasmussen, Nicholas M. Levinson

Biochem Soc Trans (2024) 52 (3): 1071–1083.

https://doi.org/10.1042/BST20230558

Published: 23 May 2024

View article titled, Exploring the conformational landscapes of protein kinases: perspectives from FRET and DEER

Articles

Research progress of ZIC5 for tumor metastasis

Yiming Zhong, Shangzhi Yang, Xianli Wang, Chuanyu Sun

Biochem Soc Trans (2024) 52 (3): 1363–1372.

https://doi.org/10.1042/BST20231263

Published: 15 May 2024

View article titled, Research progress of ZIC5 for tumor metastasis

Articles

Reprogrammed mitochondria: a central hub of cancer cell metabolism

Fabio Ciccarone, Maria Rosa Ciriolo

Biochem Soc Trans (2024) 52 (3): 1305–1315.

https://doi.org/10.1042/BST20231090

Published: 08 May 2024

View article titled, Reprogrammed mitochondria: a central hub of cancer cell metabolism

Articles

Regulation of RAF family kinases: new insights from recent structural and biochemical studies

Russell Spencer-Smith, Deborah K. Morrison

Biochem Soc Trans (2024) 52 (3): 1061–1069.

https://doi.org/10.1042/BST20230552

Published: 02 May 2024

View article titled, Regulation of RAF family kinases: new insights from recent structural and biochemical studies

Articles

Therapeutic exploitation of ferroptosis

Magali Walravens, Ine Koeken, Tom Vanden Berghe

Biochem Soc Trans (2024) 52 (2): 693–706.

https://doi.org/10.1042/BST20230550

Published: 17 April 2024

View article titled, Therapeutic exploitation of ferroptosis

Articles

Deconstructing cancer with precision genome editing

Grace A. Johnson, Samuel I. Gould, Francisco J. Sánchez-Rivera

Biochem Soc Trans (2024) 52 (2): 803–819.

https://doi.org/10.1042/BST20230984

Published: 17 April 2024

View article titled, Deconstructing cancer with precision genome editing

Articles

Complex I activity in hypoxia: implications for oncometabolism

Christos Chinopoulos

Biochem Soc Trans (2024) 52 (2): 529–538.

https://doi.org/10.1042/BST20230189

Published: 25 March 2024

View article titled, Complex I activity in hypoxia: implications for oncometabolism

Articles

Beyond protein synthesis: non-translational functions of threonyl-tRNA synthetases

Pallob Barai, Jie Chen

Biochem Soc Trans (2024) 52 (2): 661–670.

https://doi.org/10.1042/BST20230506

Published: 13 March 2024

View article titled, Beyond protein synthesis: non-translational functions of threonyl-tRNA synthetases

Articles

Bivalent chromatin: a developmental balancing act tipped in cancer

In Collection

Epigenetics

Eleanor Glancy, Natalie Choy, Melanie A. Eckersley-Maslin

Biochem Soc Trans (2024) 52 (1): 217–229.

https://doi.org/10.1042/BST20230426

Published: 22 February 2024

View article titled, Bivalent chromatin: a developmental balancing act tipped in cancer

Articles

DDX41: exploring the roles of a versatile helicase

Lacey Winstone, Yohan Jung, Yuliang Wu

Biochem Soc Trans (2024) 52 (1): 395–405.

https://doi.org/10.1042/BST20230725

Published: 13 February 2024

View article titled, DDX41: exploring the roles of a versatile helicase

Articles

Atypical RhoUV GTPases in development and disease

Stephanie Woo, Leesa Strasser

Biochem Soc Trans (2024) 52 (1): 89–97.

https://doi.org/10.1042/BST20230212

Published: 05 February 2024

View article titled, Atypical RhoUV GTPases in development and disease

Articles

Intersectin — many facets of a scaffold protein

Mubashir Mintoo, Vinodh Rajagopalan, John P. O'Bryan

Biochem Soc Trans (2024) 52 (1): 1–13.

https://doi.org/10.1042/BST20211241

Published: 04 January 2024

View article titled, Intersectin — many facets of a scaffold protein

Articles

Advances in understanding telomerase assembly

Basma M. Klump, Jens C. Schmidt

Biochem Soc Trans (2023) 51 (6): 2093–2101.

https://doi.org/10.1042/BST20230269

Published: 18 December 2023

View article titled, Advances in understanding telomerase assembly

Articles

Gas plasmas technology: from biomolecule redox research to medical therapy

Sander Bekeschus

Biochem Soc Trans (2023) 51 (6): 2071–2083.

https://doi.org/10.1042/BST20230014

Published: 13 December 2023

View article titled, Gas plasmas technology: from biomolecule redox research to medical therapy

Articles

Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity

Athanasios Papadas, Yun Huang, Alexander Cicala, Yaling Dou, Matteo Fields, Alicia Gibbons, Duncan Hong, Daniel J. Lagal, Victoria Quintana, Alejandro Rizo, Brolyn Zomalan, Fotis Asimakopoulos

Biochem Soc Trans (2023) 51 (6): 2017–2028.

https://doi.org/10.1042/BST20221083

Published: 30 November 2023

View article titled, Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity

Articles

The molecular mechanisms of diapause and diapause-like reversible arrest

Sreesankar Easwaran, Denise J. Montell

Biochem Soc Trans (2023) 51 (5): 1847–1856.

https://doi.org/10.1042/BST20221431

Published: 06 October 2023

View article titled, The molecular mechanisms of diapause and diapause-like reversible arrest

Articles

The role of peroxidasin in solid cancer progression

Kaitlin Wyllie, Vasilios Panagopoulos, Thomas R. Cox

Biochem Soc Trans (2023) 51 (5): 1881–1895.

https://doi.org/10.1042/BST20230018

Published: 06 October 2023

View article titled, The role of peroxidasin in solid cancer progression

Articles

How to fix DNA breaks: new insights into the mechanism of non-homologous end joining

Alex Vogt, Yuan He, Susan P. Lees-Miller

Biochem Soc Trans (2023) 51 (5): 1789–1800.

https://doi.org/10.1042/BST20220741

Published: 03 October 2023

View article titled, How to fix DNA breaks: new insights into the mechanism of non-homologous end joining

Articles

ALTercations at telomeres: stress, recombination and extrachromosomal affairs

Taylor K Loe, Eros Lazzerini Denchi, Gianna M. Tricola, Benura Azeroglu

Biochem Soc Trans (2023) 51 (5): 1935–1946.

https://doi.org/10.1042/BST20230265

Published: 28 September 2023

View article titled, ALTercations at telomeres: stress, recombination and extrachromosomal affairs

Articles

Histone mutations in cancer

Kimberly N. Espinoza Pereira, Jixiu Shan, Jonathan D. Licht, Richard L. Bennett

Biochem Soc Trans (2023) 51 (5): 1749–1763.

https://doi.org/10.1042/BST20210567

Published: 18 September 2023

View article titled, Histone mutations in cancer

Articles

The ARF GTPase regulatory network in collective invasion and metastasis

Konstantina Nikolatou, David M. Bryant, Emma Sandilands

Biochem Soc Trans (2023) 51 (4): 1559–1569.

https://doi.org/10.1042/BST20221355

Published: 25 August 2023

View article titled, The ARF GTPase regulatory network in collective invasion and metastasis

Articles

The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches

Emily Gruber, Lev M. Kats

Biochem Soc Trans (2023) 51 (4): 1675–1686.

https://doi.org/10.1042/BST20230017

Published: 01 August 2023

View article titled, The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches

Articles

The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer

Samuel J. Rodgers, Christina A. Mitchell, Lisa M. Ooms

Biochem Soc Trans (2023) 51 (4): 1459–1472.

https://doi.org/10.1042/BST20220866

Published: 20 July 2023

View article titled, The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer

Articles

The discovery, function, and regulation of epithelial splicing regulatory proteins (ESRP) 1 and 2

Jessica M. Derham, Auinash Kalsotra

Biochem Soc Trans (2023) 51 (3): 1097–1109.

https://doi.org/10.1042/BST20221124

Published: 14 June 2023

View article titled, The discovery, function, and regulation of epithelial splicing regulatory proteins (ESRP) 1 and 2

Articles

Contributions of coxsackievirus adenovirus receptor to tumorigenesis

Claudia Owczarek, Yassmin Elmasry, Maddy Parsons

Biochem Soc Trans (2023) 51 (3): 1143–1155.

https://doi.org/10.1042/BST20221203

Published: 12 June 2023

View article titled, Contributions of coxsackievirus adenovirus receptor to tumorigenesis

Articles

Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction

Uzma Jaffry, Geoff Wells

Biochem Soc Trans (2023) 51 (3): 925–936.

https://doi.org/10.1042/BST20220352

Published: 09 June 2023

View article titled, Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction

Articles

Experimental systems for the analysis of mutational signatures: no ‘one-size-fits-all' solution

Dmitri Ivanov, Taejoo Hwang, Lukasz Karol Sitko, Semin Lee, Anton Gartner

Biochem Soc Trans (2023) 51 (3): 1307–1317.

https://doi.org/10.1042/BST20221482

Published: 07 June 2023

View article titled, Experimental systems for the analysis of mutational signatures: no ‘one-size-fits-all' solution

Articles

Caveolae and the oxidative stress response

Yeping Wu, Ye-Wheen Lim, Robert G. Parton

Biochem Soc Trans (2023) 51 (3): 1377–1385.

https://doi.org/10.1042/BST20230121

Published: 30 May 2023

View article titled, Caveolae and the oxidative stress response

Articles

Differential functions of the KRAS splice variants

Juan Kochen Rossi, Cristina Nuevo-Tapioles, Mark R. Philips

Biochem Soc Trans (2023) 51 (3): 1191–1199.

https://doi.org/10.1042/BST20221347

Published: 24 May 2023

View article titled, Differential functions of the KRAS splice variants

Articles

The function and regulation of ADP-ribosylation in the DNA damage response

Lena Duma, Ivan Ahel

Biochem Soc Trans (2023) 51 (3): 995–1008.

https://doi.org/10.1042/BST20220749

Published: 12 May 2023

View article titled, The function and regulation of ADP-ribosylation in the DNA damage response

Articles

The assembly of the MCM2–7 hetero-hexamer and its significance in DNA replication

Yuki Hatoyama, Masato T. Kanemaki

Biochem Soc Trans (2023) 51 (3): 1289–1295.

https://doi.org/10.1042/BST20221465

Published: 05 May 2023

View article titled, The assembly of the MCM2–7 hetero-hexamer and its significance in DNA replication

Articles

The molecular mechanisms of human separase regulation

Jun Yu, David O. Morgan, Andreas Boland

Biochem Soc Trans (2023) 51 (3): 1225–1233.

https://doi.org/10.1042/BST20221400

Published: 04 May 2023

View article titled, The molecular mechanisms of human separase regulation

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