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Articles

S -acylation in apoptotic and non-apoptotic cell death: a central regulator of membrane dynamics and protein function

Open Access
Rojae Manhertz-Patterson, G. Ekin Atilla-Gokcumen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (02): 487–496.
https://doi.org/10.1042/BST20253012
Published: 29 April 2025
View articletitled, S -acylation in apoptotic and non-apoptotic cell death: a central regulator of membrane dynamics and protein function
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Articles

Extracellular membrane particles en route to the nucleus – exploring the VOR complex

Open Access
Aurelio Lorico, Mark F. Santos, Jana Karbanová, Denis Corbeil
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) BST20253005.
https://doi.org/10.1042/BST20253005
Published: 24 April 2025
View articletitled, Extracellular membrane particles en route to the nucleus – exploring the VOR complex
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Articles

Insights into non-proteinaceous ubiquitination

Open Access
Emily L. Dearlove, Danny T. Huang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (02): 399–407.
https://doi.org/10.1042/BST20253029
Published: 03 April 2025
View articletitled, Insights into non-proteinaceous ubiquitination
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Articles

Structural switching of tubulin in the microtubule lattice

Open Access
Yean-Ming Chew, Robert A. Cross
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (01): 161–171.
https://doi.org/10.1042/BST20240360
Published: 05 February 2025
View articletitled, Structural switching of tubulin in the microtubule lattice
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Articles

Activation is only the beginning: mechanisms that tune kinase substrate specificity

Open Access
Landon K. Clark, Sierra N. Cullati
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (01): 145–159.
https://doi.org/10.1042/BST20241420
Published: 05 February 2025
View articletitled, Activation is only the beginning: mechanisms that tune kinase substrate specificity
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Articles

Advances towards potential cancer therapeutics targeting Hippo signaling

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Rui Zhu, Zhihan Jiao, Fa-Xing Yu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2399–2413.
https://doi.org/10.1042/BST20240244
Published: 06 December 2024
View articletitled, Advances towards potential cancer therapeutics targeting Hippo signaling
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Articles

Beyond expectations: the development and biological activity of cytokinin oxidase/dehydrogenase inhibitors

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Jaroslav Nisler
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2297–2306.
https://doi.org/10.1042/BST20231561
Published: 07 November 2024
View articletitled, Beyond expectations: the development and biological activity of cytokinin oxidase/dehydrogenase inhibitors
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Articles

Mechanisms conferring bacterial cell wall variability and adaptivity

Open Access
Gabriel Torrens, Felipe Cava
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (5): 1981–1993.
https://doi.org/10.1042/BST20230027
Published: 26 September 2024
View articletitled, Mechanisms conferring bacterial cell wall variability and adaptivity
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Articles

Hetero-oligomeric interaction as a new regulatory mechanism for protein arginine methyltransferases

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Angela A. Bae, Y. George Zheng
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (5): 2193–2201.
https://doi.org/10.1042/BST20240242
Published: 26 September 2024
View articletitled, Hetero-oligomeric interaction as a new regulatory mechanism for protein arginine methyltransferases
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Articles

Discovery of telomerase inhibitors: existing strategies and emerging innovations

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Lauren Kageler, Elisa Aquilanti
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1957–1968.
https://doi.org/10.1042/BST20230264
Published: 28 August 2024
View articletitled, Discovery of telomerase inhibitors: existing strategies and emerging innovations
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Articles

Understanding pyrethrin biosynthesis: toward and beyond natural pesticide overproduction

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Kazuhiko Matsuda
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1927–1937.
https://doi.org/10.1042/BST20240213
Published: 13 August 2024
View articletitled, Understanding pyrethrin biosynthesis: toward and beyond natural pesticide overproduction
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Articles

Lessons from natural molecular glue degraders

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Shiyun Cao
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1191–1197.
https://doi.org/10.1042/BST20230836
Published: 12 June 2024
View articletitled, Lessons from natural molecular glue degraders
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Articles

The high-affinity tryptophan uptake transport system in human cells

Open Access
Keisuke Wakasugi, Takumi Yokosawa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1149–1158.
https://doi.org/10.1042/BST20230742
Published: 30 May 2024
View articletitled, The high-affinity tryptophan uptake transport system in human cells
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Articles

RNA m 6 A modification, signals for degradation or stabilisation?

Open Access
Guifeng Wei
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 707–717.
https://doi.org/10.1042/BST20230574
Published: 17 April 2024
View articletitled, RNA m 6 A modification, signals for degradation or stabilisation?
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Articles

Covalent activity-based probes for imaging of serine proteases

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Marcin Skorenski, Shanping Ji, Steven H. L. Verhelst
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 923–935.
https://doi.org/10.1042/BST20231450
Published: 17 April 2024
View articletitled, Covalent activity-based probes for imaging of serine proteases
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Articles

The role of lipids in genome integrity and pluripotency

Open Access
Qiyu Tian, Hoyoung Chung, Duancheng Wen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 639–650.
https://doi.org/10.1042/BST20230479
Published: 20 March 2024
View articletitled, The role of lipids in genome integrity and pluripotency
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Articles

Backbone interactions and secondary structures in phase separation of disordered proteins

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Shanlong Li, Yumeng Zhang, Jianhan Chen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 319–329.
https://doi.org/10.1042/BST20230618
Published: 13 February 2024
View articletitled, Backbone interactions and secondary structures in phase separation of disordered proteins
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Articles

CRISPR-controlled proteases

Open Access
Sam P. B. van Beljouw, Stan J. J. Brouns
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 441–453.
https://doi.org/10.1042/BST20230962
Published: 09 February 2024
View articletitled, CRISPR-controlled proteases
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Articles

Revealing chromatin-specific functions of histone deacylases

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In Collection
Epigenetics
Carlos Moreno-Yruela, Beat Fierz
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 353–365.
https://doi.org/10.1042/BST20230693
Published: 08 January 2024
View articletitled, Revealing chromatin-specific functions of histone deacylases
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Articles

Mechanisms of stress management in mitochondrial protein import

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Maryam Mukhtar, Krutika Thakkur, Agnieszka Chacinska, Piotr Bragoszewski
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (6): 2117–2126.
https://doi.org/10.1042/BST20230377
Published: 21 November 2023
View articletitled, Mechanisms of stress management in mitochondrial protein import
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Articles

The enzymes of the oxidative phase of the pentose phosphate pathway as targets of reactive species: consequences for NADPH production

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Eduardo Fuentes-Lemus, Juan Sebastián Reyes, Juan David Figueroa, Michael J. Davies, Camilo López-Alarcón
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (6): 2173–2187.
https://doi.org/10.1042/BST20231027
Published: 16 November 2023
View articletitled, The enzymes of the oxidative phase of the pentose phosphate pathway as targets of reactive species: consequences for NADPH production
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Articles

Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion

Open Access
Chris Greening, Ashleigh Kropp, Kylie Vincent, Rhys Grinter
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1921–1933.
https://doi.org/10.1042/BST20230120
Published: 25 September 2023
View articletitled, Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion
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Articles

Insights into the function of cytoglobin

Open Access
Brandon J. Reeder
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1907–1919.
https://doi.org/10.1042/BST20230081
Published: 18 September 2023
View articletitled, Insights into the function of cytoglobin
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Articles

Mitophagy-promoting agents and their ability to promote healthy-aging

Open Access
Vijigisha Srivastava, Einav Gross
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1811–1846.
https://doi.org/10.1042/BST20221363
Published: 01 September 2023
View articletitled, Mitophagy-promoting agents and their ability to promote healthy-aging
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Articles

Maximizing the performance of protein-based fluorescent biosensors

Open Access
Fu Chai, Dazhou Cheng, Yusuke Nasu, Takuya Terai, Robert E. Campbell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1585–1595.
https://doi.org/10.1042/BST20221413
Published: 11 July 2023
View articletitled, Maximizing the performance of protein-based fluorescent biosensors
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Articles

Biomimetic engineering of nonribosomal peptide synthesis

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Kexin Zhang, Hajo Kries
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1521–1532.
https://doi.org/10.1042/BST20221264
Published: 06 July 2023
View articletitled, Biomimetic engineering of nonribosomal peptide synthesis
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Articles

Mapping lipid pathways during phagocytosis

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Ojal Saharan, Siddhesh S. Kamat
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1279–1287.
https://doi.org/10.1042/BST20221424
Published: 14 June 2023
View articletitled, Mapping lipid pathways during phagocytosis
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Articles

Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction

Open Access
Uzma Jaffry, Geoff Wells
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 925–936.
https://doi.org/10.1042/BST20220352
Published: 09 June 2023
View articletitled, Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction
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Articles

Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides

Open Access
Yanran Chen, Xiongwen Cao, Ken H. Loh, Sarah A. Slavoff
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1071–1082.
https://doi.org/10.1042/BST20221074
Published: 12 May 2023
View articletitled, Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides
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Articles

Eliminating oncogenic RAS: back to the future at the drawing board

Open Access
Candy Laura Steffen, Pelin Kaya, Elisabeth Schaffner-Reckinger, Daniel Abankwa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 447–456.
https://doi.org/10.1042/BST20221343
Published: 23 January 2023
View articletitled, Eliminating oncogenic RAS: back to the future at the drawing board
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Includes: Supplementary data
Articles

Therapeutic targeting of eukaryotic initiation factor (eIF) 4E

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Jerry Pelletier, Nahum Sonenberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 113–124.
https://doi.org/10.1042/BST20220285
Published: 20 January 2023
View articletitled, Therapeutic targeting of eukaryotic initiation factor (eIF) 4E
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Articles

G4-interacting proteins endangering genomic stability at G4 DNA-forming sites

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Nayun Kim
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 403–413.
https://doi.org/10.1042/BST20221018
Published: 11 January 2023
View articletitled, G4-interacting proteins endangering genomic stability at G4 DNA-forming sites
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Articles

Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery

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Lionel Urán Landaburu, Mercedes Didier Garnham, Fernán Agüero
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 195–206.
https://doi.org/10.1042/BST20220618
Published: 06 January 2023
View articletitled, Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery
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Articles

Interactions governing transcriptional activity of nuclear receptors

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Sabab Hasan Khan, C. Denise Okafor
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1941–1952.
https://doi.org/10.1042/BST20220338
Published: 16 December 2022
View articletitled, Interactions governing transcriptional activity of nuclear receptors
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Articles

LncRNA: a new perspective on the study of neurological diseases

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Yun Ma, Siqi He, Tianhe Gu, Yixuan Liu, Shuya He, Zhisheng Jiang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 951–963.
https://doi.org/10.1042/BST20211181
Published: 06 April 2022
View articletitled, LncRNA: a new perspective on the study of neurological diseases
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Articles

Cofactor F 420 , an emerging redox power in biosynthesis of secondary metabolites

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Ghader Bashiri
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 253–267.
https://doi.org/10.1042/BST20211286
Published: 22 February 2022
View articletitled, Cofactor F 420 , an emerging redox power in biosynthesis of secondary metabolites
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Articles

Tyrosine- O -sulfation is a widespread affinity enhancer among thrombin interactors

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Jorge Ripoll-Rozada, Joshua W. C. Maxwell, Richard J. Payne, Pedro José Barbosa Pereira
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 387–401.
https://doi.org/10.1042/BST20210600
Published: 07 January 2022
View articletitled, Tyrosine- O -sulfation is a widespread affinity enhancer among thrombin interactors
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Articles

Writing and erasing O- GlcNAc from target proteins in cells

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Yun Ge, Christina M. Woo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2891–2901.
https://doi.org/10.1042/BST20210865
Published: 16 November 2021
View articletitled, Writing and erasing O- GlcNAc from target proteins in cells
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Articles

Live-cell visualization of cytochrome c : a tool to explore apoptosis

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João Pessoa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2903–2915.
https://doi.org/10.1042/BST20211028
Published: 08 November 2021
View articletitled, Live-cell visualization of cytochrome c : a tool to explore apoptosis
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Articles

Structural insights into glucocorticoid receptor function

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Filipp Frank, Eric A. Ortlund, Xu Liu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2333–2343.
https://doi.org/10.1042/BST20210419
Published: 28 October 2021
View articletitled, Structural insights into glucocorticoid receptor function
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Articles

Chemical biology approaches to study histone interactors

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Antony J. Burton, Ghaith M. Hamza, Andrew X. Zhang, Tom W. Muir
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2431–2441.
https://doi.org/10.1042/BST20210772
Published: 28 October 2021
View articletitled, Chemical biology approaches to study histone interactors
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Articles

Controlled metabolic cascades for protein synthesis in an artificial cell

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Huong Thanh Nguyen, Sungwoo Lee, Kwanwoo Shin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2143–2151.
https://doi.org/10.1042/BST20210175
Published: 08 October 2021
View articletitled, Controlled metabolic cascades for protein synthesis in an artificial cell
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Articles

The pockets guide to HLA class I molecules

Open Access
Andrea T. Nguyen, Christopher Szeto, Stephanie Gras
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2319–2331.
https://doi.org/10.1042/BST20210410
Published: 28 September 2021
View articletitled, The pockets guide to HLA class I molecules
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Articles

Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer

Open Access
In Collection
Cell death and survival
Erinna F. Lee, W. Douglas Fairlie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2381–2395.
https://doi.org/10.1042/BST20210749
Published: 13 September 2021
View articletitled, Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer
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Articles

Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments

Open Access
Magdalena E. Zasłona, A. Michael Downey, Peter H. Seeberger, Oren Moscovitz
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2411–2429.
https://doi.org/10.1042/BST20210766
Published: 08 September 2021
View articletitled, Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments
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Articles

Functional interrogation and therapeutic targeting of protein tyrosine phosphatases

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Aaron D. Krabill, Zhong-Yin Zhang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1723–1734.
https://doi.org/10.1042/BST20201308
Published: 25 August 2021
View articletitled, Functional interrogation and therapeutic targeting of protein tyrosine phosphatases
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Articles

Exploring chromatin structural roles of non-coding RNAs at imprinted domains

Open Access
David Llères, Yui Imaizumi, Robert Feil
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1867–1879.
https://doi.org/10.1042/BST20210758
Published: 02 August 2021
View articletitled, Exploring chromatin structural roles of non-coding RNAs at imprinted domains
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Articles

Unravelling the structural complexity of protein–lipid interactions with neutron reflectometry

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Luke A. Clifton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1537–1546.
https://doi.org/10.1042/BST20201071
Published: 09 July 2021
View articletitled, Unravelling the structural complexity of protein–lipid interactions with neutron reflectometry
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Articles

Progress in the therapeutic inhibition of Cdc42 signalling

Open Access
Natasha P. Murphy, Helen R. Mott, Darerca Owen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1443–1456.
https://doi.org/10.1042/BST20210112
Published: 08 June 2021
View articletitled, Progress in the therapeutic inhibition of Cdc42 signalling
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Articles

Chemical reporters to study mammalian O-glycosylation

Open Access
Kathryn E. Huxley, Lianne I. Willems
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 903–913.
https://doi.org/10.1042/BST20200839
Published: 16 April 2021
View articletitled, Chemical reporters to study mammalian O-glycosylation
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