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Articles

Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA

Mihai Solotchi, Smita S. Patel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1131–1148.
https://doi.org/10.1042/BST20230724
Published: 17 June 2024
View article titled, Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA
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Articles

The initiation of mitochondrial DNA replication

Yi Liu, Haibin Liu, Fan Zhang, Hong Xu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1243–1251.
https://doi.org/10.1042/BST20230952
Published: 17 June 2024
View article titled, The initiation of mitochondrial DNA replication
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Articles

The ring rules the chain — inositol pyrophosphates and the regulation of inorganic polyphosphate

Azmi Khan, Manisha Mallick, Jayashree S. Ladke, Rashna Bhandari
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 567–580.
https://doi.org/10.1042/BST20230256
Published: 17 April 2024
View article titled, The ring rules the chain — inositol pyrophosphates and the regulation of inorganic polyphosphate
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Articles

Covalent activity-based probes for imaging of serine proteases

Marcin Skorenski, Shanping Ji, Steven H. L. Verhelst
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 923–935.
https://doi.org/10.1042/BST20231450
Published: 17 April 2024
View article titled, Covalent activity-based probes for imaging of serine proteases
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Articles

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

Derek L. Bolhuis, Michael J. Emanuele, Nicholas G. Brown
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 241–267.
https://doi.org/10.1042/BST20230454
Published: 28 February 2024
View article titled, Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases
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Articles

Regulation of cardiomyocyte intracellular trafficking and signal transduction by protein palmitoylation

Kobina Essandoh, James P. Teuber, Matthew J. Brody
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 41–53.
https://doi.org/10.1042/BST20221296
Published: 22 February 2024
View article titled, Regulation of cardiomyocyte intracellular trafficking and signal transduction by protein palmitoylation
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Articles

DDX41: exploring the roles of a versatile helicase

Lacey Winstone, Yohan Jung, Yuliang Wu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 395–405.
https://doi.org/10.1042/BST20230725
Published: 13 February 2024
View article titled, DDX41: exploring the roles of a versatile helicase
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Articles

Adapting enzymes to improve their functionality in plants: why and how

Edmar R. Oliveira-Filho, Cătălin Voiniciuc, Andrew D. Hanson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1957–1966.
https://doi.org/10.1042/BST20230532
Published: 03 October 2023
View article titled, Adapting enzymes to improve their functionality in plants: why and how
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Articles

Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion

Chris Greening, Ashleigh Kropp, Kylie Vincent, Rhys Grinter
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1921–1933.
https://doi.org/10.1042/BST20230120
Published: 25 September 2023
View article titled, Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion
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Articles

Chemical catalysis by biological amyloids

Pernilla Wittung-Stafshede
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1967–1974.
https://doi.org/10.1042/BST20230617
Published: 25 September 2023
View article titled, Chemical catalysis by biological amyloids
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Articles

Insights into the function of cytoglobin

Brandon J. Reeder
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1907–1919.
https://doi.org/10.1042/BST20230081
Published: 18 September 2023
View article titled, Insights into the function of cytoglobin
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Articles

Negative regulation of biofilm formation by nitric oxide sensing proteins

Sweta Anantharaman, Danielle Guercio, Alicia G. Mendoza, Jason M. Withorn, Elizabeth M. Boon
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1447–1458.
https://doi.org/10.1042/BST20220845
Published: 23 August 2023
View article titled, Negative regulation of biofilm formation by nitric oxide sensing proteins
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Articles

Biochemical Society Transactions : celebrating 50 years

James M. Murphy
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1417–1418.
https://doi.org/10.1042/BST20230828
Published: 23 August 2023
View article titled, Biochemical Society Transactions : celebrating 50 years
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Articles

New insights into the mechanochemical coupling mechanism of kinesin–microtubule complexes from their high-resolution structures

Matthieu P.M.H. Benoit, Byron Hunter, John S. Allingham, Hernando Sosa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1505–1520.
https://doi.org/10.1042/BST20221238
Published: 10 August 2023
View article titled, New insights into the mechanochemical coupling mechanism of kinesin–microtubule complexes from their high-resolution structures
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Includes: Supplementary data
Articles

Unlocking the secrets of ABEs: the molecular mechanism behind their specificity

Xiaoyu Chen, Mitchell J. McAndrew, Audrone Lapinaite
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1635–1646.
https://doi.org/10.1042/BST20221508
Published: 01 August 2023
View article titled, Unlocking the secrets of ABEs: the molecular mechanism behind their specificity
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Articles

γ-Secretase fanning the fire of innate immunity

Chenge Liu, Cyrus Nikain, Yue-Ming Li
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1597–1610.
https://doi.org/10.1042/BST20221445
Published: 14 July 2023
View article titled, γ-Secretase fanning the fire of innate immunity
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Articles

Biomimetic engineering of nonribosomal peptide synthesis

Kexin Zhang, Hajo Kries
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1521–1532.
https://doi.org/10.1042/BST20221264
Published: 06 July 2023
View article titled, Biomimetic engineering of nonribosomal peptide synthesis
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Articles

Mapping lipid pathways during phagocytosis

Ojal Saharan, Siddhesh S. Kamat
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1279–1287.
https://doi.org/10.1042/BST20221424
Published: 14 June 2023
View article titled, Mapping lipid pathways during phagocytosis
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Articles

Cytoophidia and filaments: you must unlearn what you have learned

Chen-Jun Guo, Ji-Long Liu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1245–1256.
https://doi.org/10.1042/BST20221410
Published: 30 May 2023
View article titled, Cytoophidia and filaments: you must unlearn what you have learned
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Articles

The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation

Shang Liang, Rajaei Almohammed, Victoria H. Cowling
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1131–1141.
https://doi.org/10.1042/BST20221154
Published: 05 May 2023
View article titled, The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation
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Includes: Supplementary data
Articles

The molecular mechanisms of human separase regulation

Jun Yu, David O. Morgan, Andreas Boland
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1225–1233.
https://doi.org/10.1042/BST20221400
Published: 04 May 2023
View article titled, The molecular mechanisms of human separase regulation
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Articles

The functional importance of bacterial oxidative phosphonate pathways

Katharina Pallitsch, David L. Zechel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 487–499.
https://doi.org/10.1042/BST20220479
Published: 09 March 2023
View article titled, The functional importance of bacterial oxidative phosphonate pathways
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Articles

Deciphering the mechanism and function of Hsp100 unfoldases from protein structure

Grace Lee, Rebecca S. Kim, Sang Bum Lee, Sukyeong Lee, Francis T.F. Tsai
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1725–1736.
https://doi.org/10.1042/BST20220590
Published: 01 December 2022
View article titled, Deciphering the mechanism and function of Hsp100 unfoldases from protein structure
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Articles

General strategies for using amino acid sequence data to guide biochemical investigation of protein function

Emily N. Kennedy, Clay A. Foster, Sarah A. Barr, Robert B. Bourret
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1847–1858.
https://doi.org/10.1042/BST20220849
Published: 23 November 2022
View article titled, General strategies for using amino acid sequence data to guide biochemical investigation of protein function
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Articles

The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI

Dmitry Lyumkis, Nancy C. Horton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1703–1714.
https://doi.org/10.1042/BST20220547
Published: 18 November 2022
View article titled, The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI
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Articles

The functional importance of VCP to maintaining cellular protein homeostasis

Brittany A. Ahlstedt, Rakesh Ganji, Malavika Raman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1457–1469.
https://doi.org/10.1042/BST20220648
Published: 05 October 2022
View article titled, The functional importance of VCP to maintaining cellular protein homeostasis
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Articles

Unveiling the mechanisms and biosynthesis of a novel nickel-pincer enzyme

Shramana Chatterjee, Santhosh Gatreddi, Swati Gupta, Jorge L. Nevarez, Joel A. Rankin, Aiko Turmo, Jian Hu, Robert P. Hausinger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1187–1196.
https://doi.org/10.1042/BST20220490
Published: 12 August 2022
View article titled, Unveiling the mechanisms and biosynthesis of a novel nickel-pincer enzyme
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Articles

New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease

In Collection
Awards
Valerie B. O'Donnell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 1–11.
https://doi.org/10.1042/BST20210579
Published: 28 February 2022
View article titled, New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease
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Articles

IMPDH dysregulation in disease: a mini review

Anika L. Burrell, Justin M. Kollman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 71–82.
https://doi.org/10.1042/BST20210446
Published: 22 February 2022
View article titled, IMPDH dysregulation in disease: a mini review
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Articles

The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation

Daria Sicari, Janine Weber, Elena Maspero, Simona Polo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 473–485.
https://doi.org/10.1042/BST20210731
Published: 07 February 2022
View article titled, The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation
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Articles

Improving photosynthesis through the enhancement of Rubisco carboxylation capacity

Concepción Iñiguez, Pere Aguiló-Nicolau, Jeroni Galmés
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2007–2019.
https://doi.org/10.1042/BST20201056
Published: 08 October 2021
View article titled, Improving photosynthesis through the enhancement of Rubisco carboxylation capacity
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Articles

The surprising structural and mechanistic dichotomy of membrane-associated phosphoglycosyl transferases

Katherine H. O'Toole, Hannah M. Bernstein, Karen N. Allen, Barbara Imperiali
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1189–1203.
https://doi.org/10.1042/BST20200762
Published: 08 June 2021
View article titled, The surprising structural and mechanistic dichotomy of membrane-associated phosphoglycosyl transferases
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Articles

Great balls of fire: activation and signalling of inflammatory caspases

Georgia Bateman, Benjamin Hill, Ryan Knight, Dave Boucher
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1311–1324.
https://doi.org/10.1042/BST20200986
Published: 01 June 2021
View article titled, Great balls of fire: activation and signalling of inflammatory caspases
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Articles

Serpins in cartilage and osteoarthritis: what do we know?

David J. Wilkinson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 1013–1026.
https://doi.org/10.1042/BST20201231
Published: 12 April 2021
View article titled, Serpins in cartilage and osteoarthritis: what do we know?
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Articles

Collagen hydroxylysine glycosylation: non-conventional substrates for atypical glycosyltransferase enzymes

Francesca De Giorgi, Marco Fumagalli, Luigi Scietti, Federico Forneris
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 855–866.
https://doi.org/10.1042/BST20200767
Published: 11 March 2021
View article titled, Collagen hydroxylysine glycosylation: non-conventional substrates for atypical glycosyltransferase enzymes
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Articles

Plant asparaginyl endopeptidases and their structural determinants of function

Samuel G. Nonis, Joel Haywood, Joshua S. Mylne
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 965–976.
https://doi.org/10.1042/BST20200908
Published: 05 March 2021
View article titled, Plant asparaginyl endopeptidases and their structural determinants of function
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Articles

Structure and evolution of the bifidobacterial carbohydrate metabolism proteins and enzymes

Shinya Fushinobu, Maher Abou Hachem
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 563–578.
https://doi.org/10.1042/BST20200163
Published: 05 March 2021
View article titled, Structure and evolution of the bifidobacterial carbohydrate metabolism proteins and enzymes
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Articles

Computational investigations of allostery in aromatic amino acid biosynthetic enzymes

Wanting Jiao
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 415–429.
https://doi.org/10.1042/BST20200741
Published: 05 February 2021
View article titled, Computational investigations of allostery in aromatic amino acid biosynthetic enzymes
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Articles

Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications

Johan Ø. Ipsen, Magnus Hallas-Møller, Søren Brander, Leila Lo Leggio, Katja S. Johansen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 531–540.
https://doi.org/10.1042/BST20201031
Published: 15 January 2021
View article titled, Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications
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Articles

Solid-state NMR approaches to investigate large enzymes in complex with substrates and inhibitors

Anne K. Schütz
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 131–144.
https://doi.org/10.1042/BST20200099
Published: 24 December 2020
View article titled, Solid-state NMR approaches to investigate large enzymes in complex with substrates and inhibitors
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Articles

Anatomy of a twin DNA replication factory

Huilin Li, Nina Y. Yao, Michael E. O'Donnell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2769–2778.
https://doi.org/10.1042/BST20200640
Published: 10 December 2020
View article titled, Anatomy of a twin DNA replication factory
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Articles

‘PIPs’ in DNA polymerase: PCNA interaction affairs

Narottam Acharya, Shraddheya Kumar Patel, Satya Ranjan Sahu, Premlata Kumari
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2811–2822.
https://doi.org/10.1042/BST20200678
Published: 16 November 2020
View article titled, ‘PIPs’ in DNA polymerase: PCNA interaction affairs
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Articles

Protein phosphatase-1: dual activity regulation by Inhibitor-2

Sarah Lemaire, Mathieu Bollen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2229–2240.
https://doi.org/10.1042/BST20200503
Published: 14 October 2020
View article titled, Protein phosphatase-1: dual activity regulation by Inhibitor-2
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Articles

Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors

Gert N. Moll, Anneke Kuipers, Rick Rink, Tjibbe Bosma, Louwe de Vries, Pawel Namsolleck
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2195–2203.
https://doi.org/10.1042/BST20200427
Published: 14 October 2020
View article titled, Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors
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Articles

Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators

Sally C. Fletcher, Mathew L. Coleman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1843–1858.
https://doi.org/10.1042/BST20190333
Published: 28 September 2020
View article titled, Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators
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Articles

The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease

J. Shaun Lott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2029–2037.
https://doi.org/10.1042/BST20200194
Published: 11 September 2020
View article titled, The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease
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Articles

Driving antimalarial design through understanding of target mechanism

Petar P. S. Calic, Mahta Mansouri, Peter J. Scammells, Sheena McGowan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2067–2078.
https://doi.org/10.1042/BST20200224
Published: 01 September 2020
View article titled, Driving antimalarial design through understanding of target mechanism
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Articles

Chain reactions: molecular mechanisms of RBR ubiquitin ligases

Thomas R. Cotton, Bernhard C. Lechtenberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1737–1750.
https://doi.org/10.1042/BST20200237
Published: 17 July 2020
View article titled, Chain reactions: molecular mechanisms of RBR ubiquitin ligases
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Articles

Leloir glycosyltransferases of natural product C -glycosylation: structure, mechanism and specificity

Gregor Tegl, Bernd Nidetzky
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1583–1598.
https://doi.org/10.1042/BST20191140
Published: 13 July 2020
View article titled, Leloir glycosyltransferases of natural product C -glycosylation: structure, mechanism and specificity
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Articles

Functional (un)cooperativity in elevator transport proteins

Katharina Holzhüter, Eric R. Geertsma
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 1047–1055.
https://doi.org/10.1042/BST20190970
Published: 23 June 2020
View article titled, Functional (un)cooperativity in elevator transport proteins
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