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Articles

The central role of translation elongation in response to stress

Géssica C. Barros, Sofia Guerrero, Gustavo M. Silva
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 959–969.
https://doi.org/10.1042/BST20220584
Published: 15 June 2023
View article titled, The central role of translation elongation in response to stress
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Articles

Experimental systems for the analysis of mutational signatures: no ‘one-size-fits-all' solution

Dmitri Ivanov, Taejoo Hwang, Lukasz Karol Sitko, Semin Lee, Anton Gartner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1307–1317.
https://doi.org/10.1042/BST20221482
Published: 07 June 2023
View article titled, Experimental systems for the analysis of mutational signatures: no ‘one-size-fits-all' solution
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Articles

The functional importance of bacterial oxidative phosphonate pathways

Katharina Pallitsch, David L. Zechel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 487–499.
https://doi.org/10.1042/BST20220479
Published: 09 March 2023
View article titled, The functional importance of bacterial oxidative phosphonate pathways
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Articles

Uncovering novel regulators of memory using C. elegans genetic and genomic analysis

Katie L. Brandel-Ankrapp, Rachel N. Arey
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 161–171.
https://doi.org/10.1042/BST20220455
Published: 06 February 2023
View article titled, Uncovering novel regulators of memory using C. elegans genetic and genomic analysis
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Articles

Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery

Lionel Urán Landaburu, Mercedes Didier Garnham, Fernán Agüero
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 195–206.
https://doi.org/10.1042/BST20220618
Published: 06 January 2023
View article titled, Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery
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Articles

Form and function of archaeal genomes

Stephen D. Bell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1931–1939.
https://doi.org/10.1042/BST20221396
Published: 13 December 2022
View article titled, Form and function of archaeal genomes
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Articles

General strategies for using amino acid sequence data to guide biochemical investigation of protein function

Emily N. Kennedy, Clay A. Foster, Sarah A. Barr, Robert B. Bourret
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1847–1858.
https://doi.org/10.1042/BST20220849
Published: 23 November 2022
View article titled, General strategies for using amino acid sequence data to guide biochemical investigation of protein function
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Articles

Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens

Miquel Àngel Schikora-Tamarit, Toni Gabaldón
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1259–1268.
https://doi.org/10.1042/BST20211123
Published: 17 June 2022
View article titled, Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens
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Articles

Investigating chromatin accessibility during development and differentiation by ATAC-sequencing to guide the identification of cis -regulatory elements

Emily Louise Smith, Gi Fay Mok, Andrea Münsterberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1167–1177.
https://doi.org/10.1042/BST20210834
Published: 23 May 2022
View article titled, Investigating chromatin accessibility during development and differentiation by ATAC-sequencing to guide the identification of cis -regulatory elements
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Articles

Role of SWI/SNF chromatin remodeling genes in lung cancer development

Beatriz Monterde, Ignacio Varela
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1143–1150.
https://doi.org/10.1042/BST20211084
Published: 19 May 2022
View article titled, Role of SWI/SNF chromatin remodeling genes in lung cancer development
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Articles

Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions

Peter Sarkies
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1179–1190.
https://doi.org/10.1042/BST20210725
Published: 06 May 2022
View article titled, Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions
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Articles

Phenomics approaches to understand genetic networks and gene function in yeast

Clarence Hue Lok Yeung, Nil Sahin, Brenda Andrews
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 713–721.
https://doi.org/10.1042/BST20210285
Published: 14 March 2022
View article titled, Phenomics approaches to understand genetic networks and gene function in yeast
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Articles

Decoding the sorghum methylome: understanding epigenetic contributions to agronomic traits

Ulduz Vafadarshamasbi, Emma Mace, David Jordan, Peter A. Crisp
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 583–596.
https://doi.org/10.1042/BST20210908
Published: 25 February 2022
View article titled, Decoding the sorghum methylome: understanding epigenetic contributions to agronomic traits
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Articles

Control of non-productive RNA polymerase II transcription via its early termination in metazoans

Jérôme O. Rouvière, Søren Lykke-Andersen, Torben Heick Jensen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 283–295.
https://doi.org/10.1042/BST20201140
Published: 15 February 2022
View article titled, Control of non-productive RNA polymerase II transcription via its early termination in metazoans
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Articles

Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway

In Collection
Cell death and survival
Sarah E. Garnish, Joanne M. Hildebrand
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 529–539.
https://doi.org/10.1042/BST20210517
Published: 15 February 2022
View article titled, Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway
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Articles

Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin

Luke T. Marr, Prasoon Jaya, Laxmi N. Mishra, Jeffrey J. Hayes
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 199–212.
https://doi.org/10.1042/BST20210959
Published: 15 February 2022
View article titled, Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin
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Articles

The role of chromatin at transcription-replication conflicts as a genome safeguard

Aleix Bayona-Feliu, Andrés Aguilera
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2727–2736.
https://doi.org/10.1042/BST20210691
Published: 25 November 2021
View article titled, The role of chromatin at transcription-replication conflicts as a genome safeguard
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Articles

Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells

Maxim V. Zagoskin, Jianbin Wang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 1891–1903.
https://doi.org/10.1042/BST20190951
Published: 19 October 2021
View article titled, Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells
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Articles

Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease

Viola Volpato
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2091–2100.
https://doi.org/10.1042/BST20210128
Published: 28 September 2021
View article titled, Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease
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Articles

Regulation of retrotransposition in Arabidopsis

Seung Cho Lee, Robert A. Martienssen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2241–2251.
https://doi.org/10.1042/BST20210337
Published: 08 September 2021
View article titled, Regulation of retrotransposition in Arabidopsis
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Articles

Quantitative neurogenetics: applications in understanding disease

Ali Afrasiabi, Jeremy T. Keane, Julian Ik-Tsen Heng, Elizabeth E. Palmer, Nigel H. Lovell, Hamid Alinejad-Rokny
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1621–1631.
https://doi.org/10.1042/BST20200732
Published: 20 July 2021
View article titled, Quantitative neurogenetics: applications in understanding disease
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Articles

Sequence determinants, function, and evolution of CpG islands

Allegra Angeloni, Ozren Bogdanovic
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1109–1119.
https://doi.org/10.1042/BST20200695
Published: 22 June 2021
View article titled, Sequence determinants, function, and evolution of CpG islands
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Articles

Molecular genetics of renal ciliopathies

Miguel Barroso-Gil, Eric Olinger, John A. Sayer
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1205–1220.
https://doi.org/10.1042/BST20200791
Published: 07 May 2021
View article titled, Molecular genetics of renal ciliopathies
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Articles

Dynamics of bacterial adaptation

Huei-Yi Lai, Tim F. Cooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 945–951.
https://doi.org/10.1042/BST20200885
Published: 12 April 2021
View article titled, Dynamics of bacterial adaptation
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Articles

Beyond the pan-genome: current perspectives on the functional and practical outcomes of the distributed genome hypothesis

Jocelyn A. Hammond, Emma A. Gordon, Kayla M. Socarras, Joshua Chang Mell, Garth D. Ehrlich
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2437–2455.
https://doi.org/10.1042/BST20190713
Published: 27 November 2020
View article titled, Beyond the pan-genome: current perspectives on the functional and practical outcomes of the distributed genome hypothesis
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Articles

Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies

Anireddy S.N. Reddy, Jie Huang, Naeem H. Syed, Asa Ben-Hur, Suomeng Dong, Lianfeng Gu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2399–2414.
https://doi.org/10.1042/BST20190492
Published: 16 November 2020
View article titled, Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies
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Includes: Supplementary data
Articles

Architectural RNA in chromatin organization

Jitendra Thakur, Steven Henikoff
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1967–1978.
https://doi.org/10.1042/BST20191226
Published: 08 September 2020
View article titled, Architectural RNA in chromatin organization
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Articles

The evolutionary dynamics of venom toxins made by insects and other animals

Andrew A. Walker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1353–1365.
https://doi.org/10.1042/BST20190820
Published: 05 August 2020
View article titled, The evolutionary dynamics of venom toxins made by insects and other animals
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Articles

DNA copy number and structural variation (CNV) contributions to adult and childhood obesity

Megan Phillips, Jeganathan Ramesh Babu, Xu Wang, Thangiah Geetha
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1819–1828.
https://doi.org/10.1042/BST20200556
Published: 29 July 2020
View article titled, DNA copy number and structural variation (CNV) contributions to adult and childhood obesity
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Articles

Computational discovery and modeling of novel gene expression rules encoded in the mRNA

Shir Bahiri-Elitzur, Tamir Tuller
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1519–1528.
https://doi.org/10.1042/BST20191048
Published: 14 July 2020
View article titled, Computational discovery and modeling of novel gene expression rules encoded in the mRNA
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Articles

Small nucleolar RNAs: continuing identification of novel members and increasing diversity of their molecular mechanisms of action

Danny Bergeron, Étienne Fafard-Couture, Michelle S. Scott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 645–656.
https://doi.org/10.1042/BST20191046
Published: 08 April 2020
View article titled, Small nucleolar RNAs: continuing identification of novel members and increasing diversity of their molecular mechanisms of action
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Articles

Detection of CRISPR adaptation

Anna Shiriaeva, Ivan Fedorov, Danylo Vyhovskyi, Konstantin Severinov
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 257–269.
https://doi.org/10.1042/BST20190662
Published: 03 February 2020
View article titled, Detection of CRISPR adaptation
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Includes: Supplementary data
Articles

Using single-cell RNA sequencing to unravel cell lineage relationships in the respiratory tract

L.E. Zaragosi, M. Deprez, P. Barbry
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 327–336.
https://doi.org/10.1042/BST20191010
Published: 10 January 2020
View article titled, Using single-cell RNA sequencing to unravel cell lineage relationships in the respiratory tract
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Articles

Characterization and applications of Type I CRISPR-Cas systems

Claudio Hidalgo-Cantabrana, Rodolphe Barrangou
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 15–23.
https://doi.org/10.1042/BST20190119
Published: 10 January 2020
View article titled, Characterization and applications of Type I CRISPR-Cas systems
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Articles

‘Stop’ in protein synthesis is modulated with exquisite subtlety by an extended RNA translation signal

Warren P. Tate, Andrew G. Cridge, Chris M. Brown
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1615–1625.
https://doi.org/10.1042/BST20180190
Published: 12 November 2018
View article titled, ‘Stop’ in protein synthesis is modulated with exquisite subtlety by an extended RNA translation signal
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Articles

The molecular clock and evolutionary timescales

Arong Luo, Simon Y. W. Ho
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1183–1190.
https://doi.org/10.1042/BST20180186
Published: 28 August 2018
View article titled, The molecular clock and evolutionary timescales
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Articles

The biological relevance of a medieval king's DNA

Maarten H.D. Larmuseau, Martin Bodner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 1013–1020.
https://doi.org/10.1042/BST20170173
Published: 31 July 2018
View article titled, The biological relevance of a medieval king's DNA
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Articles

RHO GTPases in cancer: known facts, open questions, and therapeutic challenges

Xosé R. Bustelo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (3): 741–760.
https://doi.org/10.1042/BST20170531
Published: 05 June 2018
View article titled, RHO GTPases in cancer: known facts, open questions, and therapeutic challenges
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Articles

Studying X chromosome inactivation in the single-cell genomic era

Andrew Keniry, Marnie E. Blewitt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (3): 577–586.
https://doi.org/10.1042/BST20170346
Published: 20 April 2018
View article titled, Studying X chromosome inactivation in the single-cell genomic era
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Articles

Biomolecular coevolution and its applications: Going from structure prediction toward signaling, epistasis, and function

Mehari B. Zerihun, Alexander Schug
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1253–1261.
https://doi.org/10.1042/BST20170063
Published: 20 October 2017
View article titled, Biomolecular coevolution and its applications: Going from structure prediction toward signaling, epistasis, and function
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Articles

When mRNA translation meets decay

Alicia A. Bicknell, Emiliano P. Ricci
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (2): 339–351.
https://doi.org/10.1042/BST20160243
Published: 13 April 2017
View article titled, When mRNA translation meets decay
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Articles

Constraints in cancer evolution

Subramanian Venkatesan, Nicolai J. Birkbak, Charles Swanton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 1–13.
https://doi.org/10.1042/BST20160229
Published: 15 February 2017
View article titled, Constraints in cancer evolution
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Articles

Structure and function of bacterial H-NS protein

David C. Grainger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (6): 1561–1569.
https://doi.org/10.1042/BST20160190
Published: 02 December 2016
View article titled, Structure and function of bacterial H-NS protein
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Articles

Dawn of the in vivo RNA structurome and interactome

Chun Kit Kwok
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1395–1410.
https://doi.org/10.1042/BST20160075
Published: 19 October 2016
View article titled, Dawn of the in vivo RNA structurome and interactome
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Articles

Mutational patterns in oncogenes and tumour suppressors

Hanadi M. Baeissa, Graeme Benstead-Hume, Christopher J. Richardson, Frances M.G. Pearl
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 925–931.
https://doi.org/10.1042/BST20160001
Published: 09 June 2016
View article titled, Mutational patterns in oncogenes and tumour suppressors
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Includes: Supplementary data
Articles

‘Nothing of chemistry disappears in biology’: the Top 30 damage-prone endogenous metabolites

Claudia Lerma-Ortiz, James G. Jeffryes, Arthur J.L. Cooper, Thomas D. Niehaus, Antje M.K. Thamm, Océane Frelin, Thomas Aunins, Oliver Fiehn, Valérie de Crécy-Lagard, Christopher S. Henry, Andrew D. Hanson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 961–971.
https://doi.org/10.1042/BST20160073
Published: 09 June 2016
View article titled, ‘Nothing of chemistry disappears in biology’: the Top 30 damage-prone endogenous metabolites
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Includes: Supplementary data