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Articles

Greasing the wheels of inflammasome formation: regulation of NLRP3 function by S-linked fatty acids

Daniel M. Williams, Andrew A. Peden
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) BST20241738.
https://doi.org/10.1042/BST20241738
Published: 21 January 2025
View article titled, Greasing the wheels of inflammasome formation: regulation of NLRP3 function by S-linked fatty acids
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Articles

The integrin adhesome and control of anti-tumour immunity

Emily R. Webb, Annabel Black, Nicole D. Barth, Stefan N. Symeonides, Valerie G. Brunton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2455–2468.
https://doi.org/10.1042/BST20240386
Published: 06 December 2024
View article titled, The integrin adhesome and control of anti-tumour immunity
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Articles

Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential

Addison A. Young, Holly E. Bohlin, Jackson R. Pierce, Kyle A. Cottrell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (5): 2035–2045.
https://doi.org/10.1042/BST20230727
Published: 02 September 2024
View article titled, Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential
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Articles

Molecular aspects of Interleukin-36 cytokine activation and regulation

Jennifer Keller, James R. O’ Siorain, Thomas M. Kündig, Mark Mellett
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1591–1604.
https://doi.org/10.1042/BST20230548
Published: 28 June 2024
View article titled, Molecular aspects of Interleukin-36 cytokine activation and regulation
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Articles

Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA

Mihai Solotchi, Smita S. Patel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1131–1148.
https://doi.org/10.1042/BST20230724
Published: 17 June 2024
View article titled, Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA
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Articles

Mechanoimmunology in the solid tumor microenvironment

Matteo Golo, Peter L. H. Newman, Daryan Kempe, Maté Biro
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1489–1502.
https://doi.org/10.1042/BST20231427
Published: 10 June 2024
View article titled, Mechanoimmunology in the solid tumor microenvironment
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Articles

The high-affinity tryptophan uptake transport system in human cells

Keisuke Wakasugi, Takumi Yokosawa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1149–1158.
https://doi.org/10.1042/BST20230742
Published: 30 May 2024
View article titled, The high-affinity tryptophan uptake transport system in human cells
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Articles

A closer look at mammalian antiviral condensates

J. Monty Watkins, James M. Burke
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1393–1404.
https://doi.org/10.1042/BST20231296
Published: 23 May 2024
View article titled, A closer look at mammalian antiviral condensates
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Articles

Mature beyond their years: young children who escape detection of parasitemia despite living in settings of intense malaria transmission

Prasida Holla, Jyoti Bhardwaj, Tuan M. Tran
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1025–1034.
https://doi.org/10.1042/BST20230401
Published: 16 May 2024
View article titled, Mature beyond their years: young children who escape detection of parasitemia despite living in settings of intense malaria transmission
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Articles

Deubiquitinases in muscle physiology and disorders

Cyriel S. Olie, Darragh P. O'Brien, Hannah B.L. Jones, Zhu Liang, Andreas Damianou, Ilknur Sur-Erdem, Adán Pinto-Fernández, Vered Raz, Benedikt M. Kessler
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1085–1098.
https://doi.org/10.1042/BST20230562
Published: 08 May 2024
View article titled, Deubiquitinases in muscle physiology and disorders
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Articles

New insights into Gasdermin D pore formation

Shirin Kappelhoff, Eleonora G. Margheritis, Katia Cosentino
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 681–692.
https://doi.org/10.1042/BST20230549
Published: 18 March 2024
View article titled, New insights into Gasdermin D pore formation
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Articles

Raman micro-spectroscopy as a tool to study immunometabolism

Jiabao Xu, Karl J Morten
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 733–745.
https://doi.org/10.1042/BST20230794
Published: 13 March 2024
View article titled, Raman micro-spectroscopy as a tool to study immunometabolism
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Articles

Beyond protein synthesis: non-translational functions of threonyl-tRNA synthetases

Pallob Barai, Jie Chen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 661–670.
https://doi.org/10.1042/BST20230506
Published: 13 March 2024
View article titled, Beyond protein synthesis: non-translational functions of threonyl-tRNA synthetases
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Articles

Epigenetic changes induced by parasitic worms and their excretory-secretory products

William Harnett, Margaret M. Harnett
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 55–63.
https://doi.org/10.1042/BST20230087
Published: 09 February 2024
View article titled, Epigenetic changes induced by parasitic worms and their excretory-secretory products
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Articles

Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis

Anissa Chikh, Claudio Raimondi
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 137–150.
https://doi.org/10.1042/BST20230329
Published: 07 February 2024
View article titled, Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis
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Articles

Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity

Athanasios Papadas, Yun Huang, Alexander Cicala, Yaling Dou, Matteo Fields, Alicia Gibbons, Duncan Hong, Daniel J. Lagal, Victoria Quintana, Alejandro Rizo, Brolyn Zomalan, Fotis Asimakopoulos
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (6): 2017–2028.
https://doi.org/10.1042/BST20221083
Published: 30 November 2023
View article titled, Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity
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Articles

Guanylate-binding proteins in virus infection

Simran Chhabra, Manjula Kalia
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1621–1633.
https://doi.org/10.1042/BST20221500
Published: 03 August 2023
View article titled, Guanylate-binding proteins in virus infection
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Articles

Functions and mechanisms of the GPCR adaptor protein Norbin

Stephen A. Chetwynd, Simon Andrews, Sarah Inglesfield, Christine Delon, Nicholas T. Ktistakis, Heidi C. E. Welch
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1545–1558.
https://doi.org/10.1042/BST20221349
Published: 28 July 2023
View article titled, Functions and mechanisms of the GPCR adaptor protein Norbin
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Articles

Defining the metabolic signatures associated with human macrophage polarisation

Adrián Povo-Retana, Rodrigo Landauro-Vera, Marco Fariñas, Sergio Sánchez-García, Carlota Alvarez-Lucena, Silvia Marin, Marta Cascante, Lisardo Boscá
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1429–1436.
https://doi.org/10.1042/BST20220504
Published: 14 July 2023
View article titled, Defining the metabolic signatures associated with human macrophage polarisation
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Articles

γ-Secretase fanning the fire of innate immunity

Chenge Liu, Cyrus Nikain, Yue-Ming Li
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1597–1610.
https://doi.org/10.1042/BST20221445
Published: 14 July 2023
View article titled, γ-Secretase fanning the fire of innate immunity
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Articles

Mapping lipid pathways during phagocytosis

Ojal Saharan, Siddhesh S. Kamat
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1279–1287.
https://doi.org/10.1042/BST20221424
Published: 14 June 2023
View article titled, Mapping lipid pathways during phagocytosis
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Articles

Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence

In Collection
Coronavirus
Xiyuan Bai, Tony Schountz, Ashley M. Buckle, Janet L. Talbert, Robert A. Sandhaus, Edward D. Chan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1361–1375.
https://doi.org/10.1042/BST20230078
Published: 09 June 2023
View article titled, Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence
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Articles

Mechanisms of impairment of interferon production by SARS-CoV-2

In Collection
Coronavirus
Huy-Dung Hoang, Parisa Naeli, Tommy Alain, Seyed Mehdi Jafarnejad
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1047–1056.
https://doi.org/10.1042/BST20221037
Published: 18 May 2023
View article titled, Mechanisms of impairment of interferon production by SARS-CoV-2
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Articles

The CD56 − CD16 + NK cell subset in chronic infections

Alexander T.H. Cocker, Lisbeth A. Guethlein, Peter Parham
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1201–1212.
https://doi.org/10.1042/BST20221374
Published: 04 May 2023
View article titled, The CD56 − CD16 + NK cell subset in chronic infections
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Articles

Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system?

Giada Zanini, Valentina Selleri, Sandra Lopez Domenech, Mara Malerba, Milena Nasi, Anna Vittoria Mattioli, Marcello Pinti
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 735–745.
https://doi.org/10.1042/BST20221010
Published: 04 April 2023
View article titled, Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system?
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Articles

The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease

Samuel Strader, Andrew B. West
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 747–758.
https://doi.org/10.1042/BST20201091
Published: 04 April 2023
View article titled, The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease
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Articles

Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

Jennifer Currenti, Archita Mishra, Michael Wallace, Jacob George, Ankur Sharma
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 597–612.
https://doi.org/10.1042/BST20220157
Published: 20 March 2023
View article titled, Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response
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Articles

The role of the blood–brain barrier during neurological disease and infection

Adjanie Patabendige, Damir Janigro
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 613–626.
https://doi.org/10.1042/BST20220830
Published: 17 March 2023
View article titled, The role of the blood–brain barrier during neurological disease and infection
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Articles

Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?

Syeda Farhana Afroz, Karoline D. Raven, Grace M.E.P. Lawrence, Ronan Kapetanovic, Kate Schroder, Matthew J. Sweet
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 41–56.
https://doi.org/10.1042/BST20220014
Published: 23 February 2023
View article titled, Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?
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Articles

Towards using 3D cellular cultures to model the activation and diverse functions of macrophages

Sean Cutter, Mark D. Wright, Nicholas P. Reynolds, Katrina Jean Binger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 387–401.
https://doi.org/10.1042/BST20221008
Published: 06 February 2023
View article titled, Towards using 3D cellular cultures to model the activation and diverse functions of macrophages
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Articles

The mechanisms of alkali therapy in targeting renal diseases

Pedro Henrique Imenez Silva, Donald E. Wesson, Carsten A. Wagner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 223–232.
https://doi.org/10.1042/BST20220690
Published: 06 February 2023
View article titled, The mechanisms of alkali therapy in targeting renal diseases
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Articles

Inflammatory cell death: how macrophages sense neighbouring cell infection and damage

Xiaohui Wang, Larisa I. Labzin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 303–313.
https://doi.org/10.1042/BST20220807
Published: 25 January 2023
View article titled, Inflammatory cell death: how macrophages sense neighbouring cell infection and damage
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Articles

Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology

Steven Turner, Jonathan W. Essex, Tim Elliott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 275–285.
https://doi.org/10.1042/BST20220782
Published: 16 January 2023
View article titled, Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology
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Articles

RNA interference, an emerging component of antiviral immunity in mammals

Dario Pasquale Anobile, Enzo Z. Poirier
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 137–146.
https://doi.org/10.1042/BST20220385
Published: 06 January 2023
View article titled, RNA interference, an emerging component of antiviral immunity in mammals
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Articles

Placental extracellular vesicles in maternal-fetal communication during pregnancy

Charlène Martin, Mathilde Bergamelli, Cécile E. Malnou, Gisela D'Angelo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1785–1795.
https://doi.org/10.1042/BST20220734
Published: 09 December 2022
View article titled, Placental extracellular vesicles in maternal-fetal communication during pregnancy
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Articles

The octadecanoids: an emerging class of lipid mediators

Alessandro Quaranta, Johanna Revol-Cavalier, Craig E. Wheelock
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1569–1582.
https://doi.org/10.1042/BST20210644
Published: 01 December 2022
View article titled, The octadecanoids: an emerging class of lipid mediators
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Articles

Humoral immunity and B-cell memory in response to SARS-CoV-2 infection and vaccination

In Collection
Coronavirus
Holly A. Fryer, Gemma E. Hartley, Emily S.J. Edwards, Robyn E. O'Hehir, Menno C. van Zelm
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1643–1658.
https://doi.org/10.1042/BST20220415
Published: 24 November 2022
View article titled, Humoral immunity and B-cell memory in response to SARS-CoV-2 infection and vaccination
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Articles

RIPK1 and RIPK3 in antibacterial defence

In Collection
Cell death and survival
Hui Wen Yeap, Kaiwen W. Chen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1583–1594.
https://doi.org/10.1042/BST20211242
Published: 24 November 2022
View article titled, RIPK1 and RIPK3 in antibacterial defence
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Articles

The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

Heather M. Wilson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1673–1682.
https://doi.org/10.1042/BST20220441
Published: 23 November 2022
View article titled, The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis
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Articles

ISG15 driven cellular responses to virus infection

Deeksha Munnur, Adrianna Banducci-Karp, Sumana Sanyal
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1837–1846.
https://doi.org/10.1042/BST20220839
Published: 23 November 2022
View article titled, ISG15 driven cellular responses to virus infection
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Articles

Dynamics of phagocytosis mediated by phosphatidylserine

Daan Vorselen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1281–1291.
https://doi.org/10.1042/BST20211254
Published: 25 October 2022
View article titled, Dynamics of phagocytosis mediated by phosphatidylserine
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Articles

ERK1/2 in immune signalling

Richard M. Lucas, Lin Luo, Jennifer L. Stow
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1341–1352.
https://doi.org/10.1042/BST20220271
Published: 25 October 2022
View article titled, ERK1/2 in immune signalling
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Articles

Protective HLA-B57: T cell and natural killer cell recognition in HIV infection

Christian A. Lobos, Jonathan Downing, Lloyd J. D'Orsogna, Demetra S.M. Chatzileontiadou, Stephanie Gras
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1329–1339.
https://doi.org/10.1042/BST20220244
Published: 16 September 2022
View article titled, Protective HLA-B57: T cell and natural killer cell recognition in HIV infection
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Articles

The role of RHIM in necroptosis

In Collection
Cell death and survival
Theresa Riebeling, Ulrich Kunzendorf, Stefan Krautwald
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1197–1205.
https://doi.org/10.1042/BST20220535
Published: 30 August 2022
View article titled, The role of RHIM in necroptosis
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Articles

Host gene effects on gut microbiota in type 1 diabetes

Keyu Guo, Juan Huang, Zhiguang Zhou
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1133–1142.
https://doi.org/10.1042/BST20220004
Published: 06 May 2022
View article titled, Host gene effects on gut microbiota in type 1 diabetes
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Articles

Transgenic mouse models to study the physiological and pathophysiological roles of human Siglecs

Kelli A. McCord, Matthew S. Macauley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 935–950.
https://doi.org/10.1042/BST20211203
Published: 06 April 2022
View article titled, Transgenic mouse models to study the physiological and pathophysiological roles of human Siglecs
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Articles

Understanding immune signaling using advanced imaging techniques

Mario Brameshuber, Enrico Klotzsch, Aleks Ponjavic, Erdinc Sezgin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 853–866.
https://doi.org/10.1042/BST20210479
Published: 28 March 2022
View article titled, Understanding immune signaling using advanced imaging techniques
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Articles

Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance

Adithya Balasubramanian, Thomas John, Marie-Liesse Asselin-Labat
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 825–837.
https://doi.org/10.1042/BST20210961
Published: 28 March 2022
View article titled, Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance
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Articles

Linear ubiquitination in immune and neurodegenerative diseases, and beyond

In Collection
Cell death and survival
Fuminori Tokunaga, Fumiyo Ikeda
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 799–811.
https://doi.org/10.1042/BST20211078
Published: 28 March 2022
View article titled, Linear ubiquitination in immune and neurodegenerative diseases, and beyond
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Articles

New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease

In Collection
Awards
Valerie B. O'Donnell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 1–11.
https://doi.org/10.1042/BST20210579
Published: 28 February 2022
View article titled, New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease
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