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Articles

Lessons from natural molecular glue degraders

Shiyun Cao
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1191–1197.
https://doi.org/10.1042/BST20230836
Published: 12 June 2024
View articletitled, Lessons from natural molecular glue degraders
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Articles

Mitophagy-promoting agents and their ability to promote healthy-aging

Vijigisha Srivastava, Einav Gross
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1811–1846.
https://doi.org/10.1042/BST20221363
Published: 01 September 2023
View articletitled, Mitophagy-promoting agents and their ability to promote healthy-aging
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Articles

Structural and functional insights into the G protein-coupled receptors: CB1 and CB2

Christina A. Brust, Matthew A. Swanson, Laura M. Bohn
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1533–1543.
https://doi.org/10.1042/BST20221316
Published: 10 August 2023
View articletitled, Structural and functional insights into the G protein-coupled receptors: CB1 and CB2
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Articles

Structural insights into NMDA receptor pharmacology

Changping Zhou, Nami Tajima
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1713–1731.
https://doi.org/10.1042/BST20230122
Published: 11 July 2023
View articletitled, Structural insights into NMDA receptor pharmacology
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Articles

Novel roles for G protein-coupled receptor kinases in cardiac injury and repair

Gizem Kayki-Mutlu, Walter J. Koch
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 715–724.
https://doi.org/10.1042/BST20221317
Published: 04 April 2023
View articletitled, Novel roles for G protein-coupled receptor kinases in cardiac injury and repair
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Articles

The muscarinic M 4 acetylcholine receptor exacerbates symptoms of movement disorders

Nicole E. Chambers, Michael Millett, Jr, Mark S. Moehle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 691–702.
https://doi.org/10.1042/BST20220525
Published: 04 April 2023
View articletitled, The muscarinic M 4 acetylcholine receptor exacerbates symptoms of movement disorders
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Articles

Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease

Safak Er, Mikko Airavaara
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 245–257.
https://doi.org/10.1042/BST20220770
Published: 16 February 2023
View articletitled, Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease
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Articles

Allosteric regulation and inhibition of protein kinases

Victoria R. Mingione, YiTing Paung, Ian R. Outhwaite, Markus A. Seeliger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 373–385.
https://doi.org/10.1042/BST20220940
Published: 16 February 2023
View articletitled, Allosteric regulation and inhibition of protein kinases
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Articles

A multi-dimensional view of context-dependent G protein-coupled receptor function

In Collection
Awards
Maria Marti-Solano
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 13–20.
https://doi.org/10.1042/BST20210650
Published: 23 January 2023
View articletitled, A multi-dimensional view of context-dependent G protein-coupled receptor function
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Articles

Cardiotoxicity of pyrethroids: molecular mechanisms and therapeutic options for acute and long-term toxicity

Leisiane P. Marques, Julliane V. Joviano-Santos, Diego S. Souza, A. Santos-Miranda, D. Roman-Campos
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1737–1751.
https://doi.org/10.1042/BST20220593
Published: 16 November 2022
View articletitled, Cardiotoxicity of pyrethroids: molecular mechanisms and therapeutic options for acute and long-term toxicity
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Articles

Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?

Ekaterina Shevchenko, Tatu Pantsar
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 633–648.
https://doi.org/10.1042/BST20210837
Published: 28 February 2022
View articletitled, Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?
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Articles

Npt2a as a target for treating hyperphosphatemia

Linto Thomas, Jessica A. Dominguez Rieg, Timo Rieg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 439–446.
https://doi.org/10.1042/BST20211005
Published: 07 January 2022
View articletitled, Npt2a as a target for treating hyperphosphatemia
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Articles

Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

Shannon R. Tracey, Peter Smyth, Caroline J. Barelle, Christopher J. Scott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2253–2269.
https://doi.org/10.1042/BST20210343
Published: 28 October 2021
View articletitled, Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface
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Articles

Profiling novel pharmacology of receptor complexes using Receptor-HIT

Elizabeth K.M. Johnstone, Kevin D.G. Pfleger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1555–1565.
https://doi.org/10.1042/BST20201110
Published: 26 August 2021
View articletitled, Profiling novel pharmacology of receptor complexes using Receptor-HIT
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Articles

The use of fluorescence correlation spectroscopy to characterise the molecular mobility of G protein-coupled receptors in membrane microdomains: an update

Laura E. Kilpatrick, Stephen J. Hill
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1547–1554.
https://doi.org/10.1042/BST20201001
Published: 26 August 2021
View articletitled, The use of fluorescence correlation spectroscopy to characterise the molecular mobility of G protein-coupled receptors in membrane microdomains: an update
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Articles

Organ-on-chip applications in drug discovery: an end user perspective

Naomi Clapp, Augustin Amour, Wendy C. Rowan, Pelin L. Candarlioglu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1881–1890.
https://doi.org/10.1042/BST20210840
Published: 16 August 2021
View articletitled, Organ-on-chip applications in drug discovery: an end user perspective
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Articles

Emerging roles of adhesion G protein-coupled receptors

Matthew Rosa, Timothy Noel, Matthew Harris, Graham Ladds
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1695–1709.
https://doi.org/10.1042/BST20201144
Published: 20 July 2021
View articletitled, Emerging roles of adhesion G protein-coupled receptors
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Articles

Latest update on chemokine receptors as therapeutic targets

Wing Yee Lai, Anja Mueller
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1385–1395.
https://doi.org/10.1042/BST20201114
Published: 01 June 2021
View articletitled, Latest update on chemokine receptors as therapeutic targets
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Articles

Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance

Yoshinori Marunaka
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 715–726.
https://doi.org/10.1042/BST20200667
Published: 26 March 2021
View articletitled, Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance
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Articles

The development of proteinase-activated receptor-2 modulators and the challenges involved

Kathryn A. McIntosh, Margaret R. Cunningham, Trevor Bushell, Robin Plevin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2525–2537.
https://doi.org/10.1042/BST20200191
Published: 26 November 2020
View articletitled, The development of proteinase-activated receptor-2 modulators and the challenges involved
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Articles

Allosteric inhibition of LRRK2, where are we now

Ahmed Soliman, Fatma Nihan Cankara, Arjan Kortholt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2185–2194.
https://doi.org/10.1042/BST20200424
Published: 20 October 2020
View articletitled, Allosteric inhibition of LRRK2, where are we now
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Articles

Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors

Gert N. Moll, Anneke Kuipers, Rick Rink, Tjibbe Bosma, Louwe de Vries, Pawel Namsolleck
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2195–2203.
https://doi.org/10.1042/BST20200427
Published: 14 October 2020
View articletitled, Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors
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Articles

Inhibition of RAS: proven and potential vulnerabilities

Mariyam Zuberi, Imran Khan, John P. O'Bryan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1831–1841.
https://doi.org/10.1042/BST20190023
Published: 01 September 2020
View articletitled, Inhibition of RAS: proven and potential vulnerabilities
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Articles

The evolutionary dynamics of venom toxins made by insects and other animals

Andrew A. Walker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1353–1365.
https://doi.org/10.1042/BST20190820
Published: 05 August 2020
View articletitled, The evolutionary dynamics of venom toxins made by insects and other animals
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Articles

Targeting MmpL3 for anti-tuberculosis drug development

Jani R. Bolla
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1463–1472.
https://doi.org/10.1042/BST20190950
Published: 14 July 2020
View articletitled, Targeting MmpL3 for anti-tuberculosis drug development
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Articles

Nanodomains in cardiopulmonary disorders and the impact of air pollution

Isabella Cattani-Cavalieri, Samuel dos Santos Valença, Martina Schmidt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 799–811.
https://doi.org/10.1042/BST20190250
Published: 29 June 2020
View articletitled, Nanodomains in cardiopulmonary disorders and the impact of air pollution
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Articles

Inhibitors in AKTion: ATP-competitive vs allosteric

Glorianne Lazaro, Eleftherios Kostaras, Igor Vivanco
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 933–943.
https://doi.org/10.1042/BST20190777
Published: 26 May 2020
View articletitled, Inhibitors in AKTion: ATP-competitive vs allosteric
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Articles

Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity

Sophie L. Penman, Alice S. Carter, Amy E. Chadwick
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 787–797.
https://doi.org/10.1042/BST20190233
Published: 26 May 2020
View articletitled, Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity
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Articles

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

Jia Jin Hiu, Michelle Khai Khun Yap
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 719–731.
https://doi.org/10.1042/BST20200110
Published: 08 April 2020
View articletitled, Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase
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Articles

Small molecules that target the ubiquitin system

Hai Qiu Wu, David Baker, Huib Ovaa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 479–497.
https://doi.org/10.1042/BST20190535
Published: 20 March 2020
View articletitled, Small molecules that target the ubiquitin system
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Articles

Studying signal compartmentation in adult cardiomyocytes

Aleksandra Judina, Julia Gorelik, Peter T. Wright
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 61–70.
https://doi.org/10.1042/BST20190247
Published: 27 February 2020
View articletitled, Studying signal compartmentation in adult cardiomyocytes
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Articles

New aspects in cardiac L-type Ca 2+ channel regulation

Tamara Pallien, Enno Klussmann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 39–49.
https://doi.org/10.1042/BST20190229
Published: 17 February 2020
View articletitled, New aspects in cardiac L-type Ca 2+ channel regulation
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Articles

Amphipathic molecules modulate PIEZO1 activity

Charles D. Cox, Philip A. Gottlieb
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1833–1842.
https://doi.org/10.1042/BST20190372
Published: 22 November 2019
View articletitled, Amphipathic molecules modulate PIEZO1 activity
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Articles

cGMP signalling in cardiomyocyte microdomains

Nadja I. Bork, Cristina E. Molina, Viacheslav O. Nikolaev
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1327–1339.
https://doi.org/10.1042/BST20190225
Published: 11 October 2019
View articletitled, cGMP signalling in cardiomyocyte microdomains
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Articles

Swimming regulations for protein kinase A catalytic subunit

Matthew G. Gold
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1355–1366.
https://doi.org/10.1042/BST20190230
Published: 11 October 2019
View articletitled, Swimming regulations for protein kinase A catalytic subunit
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Articles

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

Brendan Farrell, Alexander L. Breeze
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1753–1770.
https://doi.org/10.1042/BST20180004
Published: 13 December 2018
View articletitled, Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting
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Articles

Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability

Obinna C. Ubah, Magdalena J. Buschhaus, Laura Ferguson, Marina Kovaleva, John Steven, Andrew J. Porter, Caroline J. Barelle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1559–1565.
https://doi.org/10.1042/BST20180177
Published: 31 October 2018
View articletitled, Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability
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Articles

Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body

Régis Stentz, Ana L. Carvalho, Emily J. Jones, Simon R. Carding
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1021–1027.
https://doi.org/10.1042/BST20180114
Published: 28 August 2018
View articletitled, Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body
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Articles

Ras proteins as therapeutic targets

Atanu Chakraborty, Emily Linnane, Sarah Ross
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1303–1311.
https://doi.org/10.1042/BST20170529
Published: 28 August 2018
View articletitled, Ras proteins as therapeutic targets
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Articles

Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease

Courtney J. Mycroft-West, Edwin A. Yates, Mark A. Skidmore
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 919–929.
https://doi.org/10.1042/BST20170404
Published: 19 July 2018
View articletitled, Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease
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Articles

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Ruby Macdonald, Katy Barnes, Christopher Hastings, Heather Mortiboys
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 891–909.
https://doi.org/10.1042/BST20170501
Published: 19 July 2018
View articletitled, Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?
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Articles

Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

Thomas Briston, Amy R. Hicks
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 829–842.
https://doi.org/10.1042/BST20180025
Published: 09 July 2018
View articletitled, Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention
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Articles

MSC exosome works through a protein-based mechanism of action

Wei Seong Toh, Ruenn Chai Lai, Bin Zhang, Sai Kiang Lim
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 843–853.
https://doi.org/10.1042/BST20180079
Published: 09 July 2018
View articletitled, MSC exosome works through a protein-based mechanism of action
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Articles

Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?

Dunja Aksentijevic, Brett A. O'Brien, Thomas R. Eykyn, Michael J. Shattock
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 817–827.
https://doi.org/10.1042/BST20170508
Published: 03 July 2018
View articletitled, Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?
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Articles

Logic-gated approaches to extend the utility of chimeric antigen receptor T-cell technology

Lisa M. Ebert, Wenbo Yu, Tessa Gargett, Michael P. Brown
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (2): 391–401.
https://doi.org/10.1042/BST20170178
Published: 14 March 2018
View articletitled, Logic-gated approaches to extend the utility of chimeric antigen receptor T-cell technology
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Articles

MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target

David Mellis, Andrea Caporali
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 11–21.
https://doi.org/10.1042/BST20170037
Published: 01 December 2017
View articletitled, MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target
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Articles

Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory

Scott W. Burnside, Giles E. Hardingham
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1295–1303.
https://doi.org/10.1042/BST20170013
Published: 17 November 2017
View articletitled, Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory
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Articles

Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms

Bernd Gesslbauer, Valery Bochkov
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1225–1252.
https://doi.org/10.1042/BST20160473
Published: 03 November 2017
View articletitled, Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms
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Articles

Oxidative stress and endoplasmic reticulum (ER) stress in the development of neonatal hypoxic–ischaemic brain injury

Claire Thornton, Ana A. Baburamani, Anton Kichev, Henrik Hagberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (5): 1067–1076.
https://doi.org/10.1042/BST20170017
Published: 22 September 2017
View articletitled, Oxidative stress and endoplasmic reticulum (ER) stress in the development of neonatal hypoxic–ischaemic brain injury
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Articles

Targeting the hepatocyte growth factor/Met pathway in cancer

Dinuka M. De Silva, Arpita Roy, Takashi Kato, Fabiola Cecchi, Young H. Lee, Kunio Matsumoto, Donald P. Bottaro
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (4): 855–870.
https://doi.org/10.1042/BST20160132
Published: 03 July 2017
View articletitled, Targeting the hepatocyte growth factor/Met pathway in cancer
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