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Articles

UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential

Open Access
Autumn M. Matthews, Alexandra M. Whiteley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) BST20253053.
https://doi.org/10.1042/BST20253053
Published: 14 July 2025
View article titled, UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential
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Articles

Advances in understanding and targeting eIF4E activity

Open Access
Sabrina D'Agostino, Caitlin Davies, Marissa V Powers, Paul A Clarke
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) BST20241045.
https://doi.org/10.1042/BST20241045
Published: 09 July 2025
View article titled, Advances in understanding and targeting eIF4E activity
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Articles

Extracellular membrane particles en route to the nucleus – exploring the VOR complex

Open Access
Aurelio Lorico, Mark F. Santos, Jana Karbanová, Denis Corbeil
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (03): 529–546.
https://doi.org/10.1042/BST20253005
Published: 24 April 2025
View article titled, Extracellular membrane particles en route to the nucleus – exploring the VOR complex
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Articles

‘Where is my gap’: mechanisms underpinning PARP inhibitor sensitivity in cancer

Open Access
Lauryn Buckley-Benbow, Alessandro Agnarelli, Roberto Bellelli
Journal: Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (01): 225–234.
https://doi.org/10.1042/BST20241633
Published: 10 February 2025
View article titled, ‘Where is my gap’: mechanisms underpinning PARP inhibitor sensitivity in cancer
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Articles

The integrin adhesome and control of anti-tumour immunity

Open Access
Emily R. Webb, Annabel Black, Nicole D. Barth, Stefan N. Symeonides, Valerie G. Brunton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2455–2468.
https://doi.org/10.1042/BST20240386
Published: 06 December 2024
View article titled, The integrin adhesome and control of anti-tumour immunity
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Articles

Molecular regulators of chemotaxis in human hematopoietic stem cells

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Yining Liu, Nanxi Geng, Xinxin Huang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2427–2437.
https://doi.org/10.1042/BST20240288
Published: 25 November 2024
View article titled, Molecular regulators of chemotaxis in human hematopoietic stem cells
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Articles

The role of prokaryotic argonautes in resistance to type II topoisomerases poison ciprofloxacin

Open Access
Alina Galivondzhyan, Dmitry Sutormin, Vladimir Panteleev, Andrey Kulbachinskiy, Konstantin Severinov
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (5): 2157–2166.
https://doi.org/10.1042/BST20240094
Published: 24 October 2024
View article titled, The role of prokaryotic argonautes in resistance to type II topoisomerases poison ciprofloxacin
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Includes: Supplementary data
Articles

Discovery of telomerase inhibitors: existing strategies and emerging innovations

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Lauren Kageler, Elisa Aquilanti
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1957–1968.
https://doi.org/10.1042/BST20230264
Published: 28 August 2024
View article titled, Discovery of telomerase inhibitors: existing strategies and emerging innovations
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Articles

Targeting endocytosis to sensitize cancer cells to programmed cell death

Open Access
Emily T. Chan, Cömert Kural
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1703–1713.
https://doi.org/10.1042/BST20231332
Published: 02 August 2024
View article titled, Targeting endocytosis to sensitize cancer cells to programmed cell death
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Articles

Dopamine synthesis and transport: current and novel therapeutics for parkinsonisms

Open Access
Mary Dayne Sia Tai, Gloria Gamiz-Arco, Aurora Martinez
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1275–1291.
https://doi.org/10.1042/BST20231061
Published: 30 May 2024
View article titled, Dopamine synthesis and transport: current and novel therapeutics for parkinsonisms
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Articles

Making the leap from technique to treatment — genetic engineering is paving the way for more efficient phage therapy

Open Access
Jessica M. Lewis, Joshua Williams, Antonia P. Sagona
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1373–1384.
https://doi.org/10.1042/BST20231289
Published: 08 May 2024
View article titled, Making the leap from technique to treatment — genetic engineering is paving the way for more efficient phage therapy
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Articles

Bone morphogenetic protein signalling in pulmonary arterial hypertension: revisiting the BMPRII connection

Open Access
Wei Li, Kate Quigley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1515–1528.
https://doi.org/10.1042/BST20231547
Published: 08 May 2024
View article titled, Bone morphogenetic protein signalling in pulmonary arterial hypertension: revisiting the BMPRII connection
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Articles

Let's get fat: emergence of S -acylation as a therapeutic target in Huntington disease

Available to Purchase
Dale D.O. Martin, Shaun S. Sanders
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1385–1392.
https://doi.org/10.1042/BST20231290
Published: 02 May 2024
View article titled, Let's get fat: emergence of S -acylation as a therapeutic target in Huntington disease
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Articles

Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Open Access
Elizaveta A. Olkhova, Laura A. Smith, Bethany H. Dennis, Yi Shiau Ng, Fiona E. N. LeBeau, Gráinne S. Gorman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 553–565.
https://doi.org/10.1042/BST20230191
Published: 02 April 2024
View article titled, Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction
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Articles

Effects of carotenoids on mitochondrial dysfunction

Open Access
Opeyemi Stella Ademowo, Olubukola Oyebode, Roshita Edward, Myra E. Conway, Helen R. Griffiths, Irundika H.K. Dias
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 65–74.
https://doi.org/10.1042/BST20230193
Published: 22 February 2024
View article titled, Effects of carotenoids on mitochondrial dysfunction
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Articles

Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD

Available to Purchase
Polett Garcés, Armando Amaro, Martin Montecino, Brigitte van Zundert
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 123–135.
https://doi.org/10.1042/BST20230257
Published: 07 February 2024
View article titled, Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD
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Articles

Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity

Open Access
Athanasios Papadas, Yun Huang, Alexander Cicala, Yaling Dou, Matteo Fields, Alicia Gibbons, Duncan Hong, Daniel J. Lagal, Victoria Quintana, Alejandro Rizo, Brolyn Zomalan, Fotis Asimakopoulos
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (6): 2017–2028.
https://doi.org/10.1042/BST20221083
Published: 30 November 2023
View article titled, Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity
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Articles

The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches

Open Access
Emily Gruber, Lev M. Kats
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1675–1686.
https://doi.org/10.1042/BST20230017
Published: 01 August 2023
View article titled, The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches
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Articles

Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction

Open Access
Uzma Jaffry, Geoff Wells
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 925–936.
https://doi.org/10.1042/BST20220352
Published: 09 June 2023
View article titled, Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction
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Articles

Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence

Open Access
In Collection
Coronavirus
Xiyuan Bai, Tony Schountz, Ashley M. Buckle, Janet L. Talbert, Robert A. Sandhaus, Edward D. Chan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1361–1375.
https://doi.org/10.1042/BST20230078
Published: 09 June 2023
View article titled, Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence
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Articles

Exploring microRNAs in craniofacial regenerative medicine

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Dan Su, Samuel Swearson, Tadkamol Krongbaramee, Hongli Sun, Liu Hong, Brad A. Amendt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 841–854.
https://doi.org/10.1042/BST20221448
Published: 19 April 2023
View article titled, Exploring microRNAs in craniofacial regenerative medicine
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Articles

CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy

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Mario K. Shammas, Tzu-Hsiang Huang, Derek P. Narendra
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 797–809.
https://doi.org/10.1042/BST20221365
Published: 06 April 2023
View article titled, CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy
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Articles

The muscarinic M 4 acetylcholine receptor exacerbates symptoms of movement disorders

Open Access
Nicole E. Chambers, Michael Millett, Jr, Mark S. Moehle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 691–702.
https://doi.org/10.1042/BST20220525
Published: 04 April 2023
View article titled, The muscarinic M 4 acetylcholine receptor exacerbates symptoms of movement disorders
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Articles

Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease

Available to Purchase
Safak Er, Mikko Airavaara
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 245–257.
https://doi.org/10.1042/BST20220770
Published: 16 February 2023
View article titled, Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease
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Articles

Targeting NRF2 to promote epithelial repair

Open Access
Paul Hiebert, Sabine Werner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 101–111.
https://doi.org/10.1042/BST20220228
Published: 10 February 2023
View article titled, Targeting NRF2 to promote epithelial repair
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Articles

A multi-dimensional view of context-dependent G protein-coupled receptor function

Open Access
In Collection
Awards
Maria Marti-Solano
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 13–20.
https://doi.org/10.1042/BST20210650
Published: 23 January 2023
View article titled, A multi-dimensional view of context-dependent G protein-coupled receptor function
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Articles

Structural analysis of mycobacterial electron transport chain complexes by cryoEM

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Yingke Liang, John L. Rubinstein
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 183–193.
https://doi.org/10.1042/BST20220611
Published: 20 January 2023
View article titled, Structural analysis of mycobacterial electron transport chain complexes by cryoEM
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Articles

Therapeutic targeting of eukaryotic initiation factor (eIF) 4E

Available to Purchase
Jerry Pelletier, Nahum Sonenberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 113–124.
https://doi.org/10.1042/BST20220285
Published: 20 January 2023
View article titled, Therapeutic targeting of eukaryotic initiation factor (eIF) 4E
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Articles

Therapeutic targeting of TRAIL death receptors

Open Access
In Collection
Cell death and survival
Francesca Di Cristofano, Andrew George, Vida Tajiknia, Maryam Ghandali, Laura Wu, Yiqun Zhang, Praveen Srinivasan, Jillian Strandberg, Marina Hahn, Ashley Sanchez Sevilla Uruchurtu, Attila A. Seyhan, Benedito A. Carneiro, Lanlan Zhou, Kelsey E. Huntington, Wafik S. El-Deiry
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 57–70.
https://doi.org/10.1042/BST20220098
Published: 11 January 2023
View article titled, Therapeutic targeting of TRAIL death receptors
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Articles

How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes

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Shirin Hosseini, Martin Korte
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 259–274.
https://doi.org/10.1042/BST20220771
Published: 06 January 2023
View article titled, How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes
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Articles

Targeting the DNA damage response for cancer therapy

Open Access
In Collection
Awards
Nicola J. Curtin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 207–221.
https://doi.org/10.1042/BST20220681
Published: 06 January 2023
View article titled, Targeting the DNA damage response for cancer therapy
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Articles

Exploring craniofacial and dental development with microRNAs

Available to Purchase
Dan Su, Tadkamol Krongbaramee, Hongli Sun, Liu Hong, Brad A. Amendt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1897–1909.
https://doi.org/10.1042/BST20221042
Published: 09 December 2022
View article titled, Exploring craniofacial and dental development with microRNAs
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Articles

Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments

Open Access
Sharissa L. Latham, Yolande E.I. O'Donnell, David R. Croucher
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1823–1836.
https://doi.org/10.1042/BST20220808
Published: 01 December 2022
View article titled, Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments
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Articles

The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

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Heather M. Wilson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1673–1682.
https://doi.org/10.1042/BST20220441
Published: 23 November 2022
View article titled, The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis
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Articles

The role of sensory kinase proteins in two-component signal transduction

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Adrián F. Alvarez, Dimitris Georgellis
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1859–1873.
https://doi.org/10.1042/BST20220848
Published: 18 November 2022
View article titled, The role of sensory kinase proteins in two-component signal transduction
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Articles

Cancer cells hijack RNA processing to rewrite the message

Open Access
Katherine L.B. Borden
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1447–1456.
https://doi.org/10.1042/BST20220621
Published: 25 October 2022
View article titled, Cancer cells hijack RNA processing to rewrite the message
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Articles

The role of autophagy-lysosomal pathway in motor neuron diseases

Open Access
Barbara Tedesco, Veronica Ferrari, Marta Cozzi, Marta Chierichetti, Elena Casarotto, Paola Pramaggiore, Francesco Mina, Margherita Piccolella, Riccardo Cristofani, Valeria Crippa, Paola Rusmini, Mariarita Galbiati, Angelo Poletti
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1489–1503.
https://doi.org/10.1042/BST20220778
Published: 16 September 2022
View article titled, The role of autophagy-lysosomal pathway in motor neuron diseases
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Articles

Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

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Paul T. Morse, Junmei Wan, Jamie Bell, Icksoo Lee, Dennis J. Goebel, Moh H. Malek, Thomas H. Sanderson, Maik Hüttemann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1377–1388.
https://doi.org/10.1042/BST20220446
Published: 06 September 2022
View article titled, Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury
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Articles

Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging

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Hanwen Zhang, Xiaohui Lin, Shan Zha
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1169–1177.
https://doi.org/10.1042/BST20220366
Published: 12 August 2022
View article titled, Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging
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Articles

Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy

Open Access
Kendelle J. Murphy, Jessie Zhu, Michael Trpceski, Brooke A. Pereira, Paul Timpson, David Herrmann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1129–1141.
https://doi.org/10.1042/BST20220162
Published: 05 August 2022
View article titled, Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy
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Articles

Last but not least: BFL-1 as an emerging target for anti-cancer therapies

Open Access
Gaoyuan Wang, Sarah T. Diepstraten, Marco J. Herold
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1119–1128.
https://doi.org/10.1042/BST20220153
Published: 28 July 2022
View article titled, Last but not least: BFL-1 as an emerging target for anti-cancer therapies
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Articles

Three-dimensional models of the lung: past, present and future: a mini review

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Chandani Sen, Delilah Freund, Brigitte N. Gomperts
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 1045–1056.
https://doi.org/10.1042/BST20190569
Published: 11 April 2022
View article titled, Three-dimensional models of the lung: past, present and future: a mini review
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Articles

Daylight-PDT: everything under the sun

Open Access
Dana Beiki, Ian M. Eggleston, Charareh Pourzand
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 975–985.
https://doi.org/10.1042/BST20200822
Published: 06 April 2022
View article titled, Daylight-PDT: everything under the sun
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Articles

MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains

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Steven R. Van Doren
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 839–851.
https://doi.org/10.1042/BST20210640
Published: 28 March 2022
View article titled, MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains
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Articles

Therapeutic targeting of mitophagy in Parkinson's disease

Open Access
In Collection
Cell death and survival
Shashank Masaldan, Sylvie Callegari, Grant Dewson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 783–797.
https://doi.org/10.1042/BST20211107
Published: 21 March 2022
View article titled, Therapeutic targeting of mitophagy in Parkinson's disease
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Articles

Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation

Open Access
Rita Alonaizan, Carolyn Carr
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 269–281.
https://doi.org/10.1042/BST20210231
Published: 07 February 2022
View article titled, Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation
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Articles

The molecular pathogenesis of repeat expansion diseases

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Yuzo Fujino, Yoshitaka Nagai
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 119–134.
https://doi.org/10.1042/BST20200143
Published: 23 December 2021
View article titled, The molecular pathogenesis of repeat expansion diseases
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Articles

Isocitrate dehydrogenase gene variants in cancer and their clinical significance

Open Access
Thomas Cadoux-Hudson, Christopher J. Schofield, James S.O. McCullagh
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2561–2572.
https://doi.org/10.1042/BST20210277
Published: 02 December 2021
View article titled, Isocitrate dehydrogenase gene variants in cancer and their clinical significance
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Articles

The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines

Open Access
Kensaku Murano, Youjia Guo, Haruhiko Siomi
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2879–2890.
https://doi.org/10.1042/BST20210859
Published: 02 December 2021
View article titled, The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines
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Articles

Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

Open Access
Shannon R. Tracey, Peter Smyth, Caroline J. Barelle, Christopher J. Scott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2253–2269.
https://doi.org/10.1042/BST20210343
Published: 28 October 2021
View article titled, Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface
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