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Keywords: β-amyloid
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Biochem Soc Trans (2017) 45 (4): 1025–1033.
Published: 21 July 2017
... features including the involvement of mitochondria in the mechanism of pathology and misfolding and the accumulation of abnormally aggregated proteins. Neurotoxicity of aggregated β-amyloid, tau, α-synuclein and huntingtin is linked to the effects of these proteins on mitochondria. All these misfolded...
Biochem Soc Trans (2009) 37 (4): 692–696.
Published: 22 July 2009
... β-amyloid Parkinson's disease Amyloid fibrils are found as deposits of proteinaceous aggregates in patients with a range of diseases including BSE (bovine spongiform encephalopathy), vCJD (variant Creutzfeldt–Jakob disease), AD (Alzheimer's disease), PD (Parkinson's disease) and Type 2...
Biochem Soc Trans (2005) 33 (5): 1033–1036.
Published: 26 October 2005
... high-cholesterol diet improves spatial memory in experimental animals. β-Amyloid, the toxic peptide in neurons of AD (Alzheimer's disease) patients, binds cholesterol and catalyses its oxidation to 7β-hydroxycholesterol, a highly toxic oxysterol that is a potent inhibitor of α-PKC (α-protein kinase C...
Biochem Soc Trans (2005) 33 (5): 1111–1112.
Published: 26 October 2005
...G. Gibson; O.M.A. El-Agnaf; Z. Anwar; C. Sidera; A. Isbister; B.M. Austen A number of human neurodegenerative diseases involve aggregated amyloid proteins in the brain, e.g. Alzheimer's disease (β-amyloid) and Parkinson's disease (α-synuclein). Other examples are rare familial dementias which...