1-8 of 8
Keywords: β-arrestin
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Biochem Soc Trans (2013) 41 (1): 231–236.
Published: 29 January 2013
... are supported by G-protein-independent, β-arrestin-dependent signalling events. In the present article, we review current knowledge on structural and signalling properties of ACRs that are changing our view on this entire class of receptors from silent to endogenous β-arrestin-biased signalling receptors...
Biochem Soc Trans (2013) 41 (1): 135–136.
Published: 29 January 2013
..., kinases and β-arrestins) and on the dynamics of the interconversion among all these states. To improve on this will require collaborations between biophysicists and molecular modellers, as well as biochemists and pharmacologists, to use existing techniques and develop new tools to solve the problems...
Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
...K.D.G. Pfleger; M.B. Dalrymple; J.R. Dromey; K.A. Eidne β-Arrestins 1 and 2 are ubiquitously expressed intracellular adaptor and scaffolding proteins that play important roles in GPCR (G-protein-coupled receptor) desensitization, internalization, intracellular trafficking and G-protein-independent...
Biochem Soc Trans (2006) 34 (4): 474–475.
Published: 21 July 2006
..., by using either a selective inhibitor or siRNA knockout, results in accelerated isoprenaline-induced GRK2 recruitment, GRK2 phosphorylation of the β 2 Ar and β-arrestin translocation to the β 2 Ar. Surprisingly, however, we have also shown that these effects can occur, albeit to a reduced extent, merely...
Biochem Soc Trans (2003) 31 (6): 1191–1197.
Published: 01 December 2003
... is attenuated by β-arrestin-mediated desensitization and endocytosis, and by lysosomal targeting and degradation, which requires ubiquitination of PAR 2 . β-Arrestins also act as scaffolds for the assembly of multi-protein signalling complexes that determine the location and function of activated mitogen...
Biochem Soc Trans (2001) 29 (4): 505–508.
Published: 01 August 2001
... acetylcholine receptors (mAChRs). Using the transient expression system of HEK-293 cells, we showed that the M 1 , M 3 and M 4 mAChRs are internalized into clathrin-coated vesicles and recycle back to the plasma membrane. This internalization pathway is dependent on the concerted action of β-arrestin, c-Src...