...Pablo Astudillo The Wnt/β-catenin signaling pathway plays fundamental roles during development, stem cell differentiation, and homeostasis, and its abnormal activation can lead to diseases. In recent years, it has become clear that this pathway integrates signals not only from Wnt ligands but also...

...Bente Kofahl; Jana Wolf The Wnt/β-catenin pathway plays an important role in development and disease. Theoretical approaches have been used to describe this pathway and have provided intriguing insights into its signalling characteristics. In the present paper, we review mathematical models...

... on a possible role of an emerin–β-catenin interaction in the pathogenesis of this disease. 1 To whom correspondence should be addressed (email [email protected] ). 8 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 β-catenin dilated cardiomyopathy...

... a single gene, we have produced many of the phenotypes that are associated with early colorectal lesions: failed differentiation, increased proliferation, aberrant migration and loss of euploidy. Furthermore, we show a large number of molecular changes centring on activation of β-catenin/TCF4 transcription...

... stimulation, β-catenin is translocated to the nucleus, triggering the transcriptional activity of the TCF (T-cell factor)/LEF (lymphoid enhancer factor) family of transcription factors. These events are dependent on phosphoinositide-3 kinase activation and glycogen synthase kinase inhibition. Our data suggest...

... (adenomatous polyposis coli) genes occur early in the development of CRC and lead to the stabilization of the Wnt pathway component β-catenin and to the constitutive activation of Wnt signalling. Stabilizing mutations of β-catenin can also lead to its accumulation, qualifying β-catenin as a proto-oncogene...

...E.D. Martin; M. Grealy Plakoglobin (γ-catenin) and β-catenin are major components of the adherens junctions and can be localized to the nucleus by activation of the Wnt signalling pathway. In addition, plakoglobin is also found in desmosomes, a vertebrate-specific cell–cell adhesion structure...

... of inducing new pathologies. 1 To whom correspondence should be addressed (email [email protected] ). 13 8 2004 © 2004 The Biochemical Society 2004 The Wnt-induced mechanism precluding GSK-3's phosphorylation of β-catenin remains elusive. Wnt treatment of human embryonic...