... by two enzymes referred to as β- and γ-secretase. β-Secretase is of central importance, as it catalyses the rate-limiting step in the production of Aβ and was identified 7 years ago as BACE1 (β-site APP-cleaving enzyme 1). Soon afterwards, its homologue BACE2 was discovered, and both proteins represent...

...R.B. Parsons; J.K. Farrant; G.C. Price; D. Subramaniam; B.M. Austen Statins inhibit the dimerization of β-secretase [BACE (β-site amyloid precursor protein-cleaving enzyme)] by inhibiting the lipidation of BACE and associated proteins. Our studies have demonstrated a clearly defined temporal...

...C. Sidera; R. Parsons; B. Austen β-Amyloid, a neurotoxic peptide deposited in the brains of Alzheimer's disease patients, is released by a series of membrane-limited proteolytic events. β-Secretase activity is enhanced by cellular targeting into intracellular cholesterol-rich microdomains, which...

... medicines that have already been proved safe to use in humans. 1 To whom correspondence should be addressed (e-mail [email protected] ) 19 3 2002 © 2002 Biochemical Society 2002 amyloid-β peptide β-secretase statin AD, Alzheimer's disease HMG-CoA reductase, 3-hydroxy-3...