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Keywords: γ-secretase
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Articles
Biochem Soc Trans (2017) 45 (6): 1185–1202.
Published: 27 October 2017
... receptors by membrane-bound proteases and the γ-secretase protease complexes. Proteolysis enables the liberation of soluble receptor ectodomains and the generation of intracellular receptor cytoplasmic domain fragments. The combined and sequential enzymatic activity has been defined as regulated...
Articles
Biochem Soc Trans (2011) 39 (2): 541–546.
Published: 22 March 2011
... stub can be carried out by the γ-secretase (also termed presenilin) complex acting on truncated type I transmembrane proteins, signal peptide peptidases (acting on truncated type II transmembrane proteins), S2P or rhomboids [ 31 ]. Given its pathological relevance in Alzheimer's disease, the study...
Articles
Biochem Soc Trans (2010) 38 (6): 1474–1478.
Published: 24 November 2010
...) and APP (amyloid precursor protein), in patients with FAD (familial AD) has made an important contribution towards an understanding of the disease aetiology; however, a complete molecular mechanism is still lacking. Both presenilins belong to the γ-secretase complex, and serve as the catalytic entity...
Articles
Biochem Soc Trans (2007) 35 (2): 416–420.
Published: 20 March 2007
... proteases (β- and γ-secretases) that are leading candidates for therapeutic intervention. APP is a member of a multigene family that includes APLP1 (amyloid precursor-like protein 1) and APLP2. Both APLPs are processed in a manner analogous to APP, with all three proteins subject to ectodomain shedding...
Articles
Biochem Soc Trans (2006) 34 (4): 607–611.
Published: 21 July 2006
... neuroprotective effects for the treatment of neurodegenerative diseases. Like amyloid precursor protein and Notch, p75 is a substrate for γ-secretase cleavage. The p75 receptor undergoes an α-secretase-mediated release of the extracellular domain followed by a γ-secretase-mediated intramembrane cleavage. Cleavage...
Articles
Biochem Soc Trans (2005) 33 (4): 559–562.
Published: 01 August 2005
...T. Raemaekers; C. Esselens; W. Annaert Presenilin 1 plays a central catalytic role in the γ-secretase processing of amyloid precursor protein, Notch and many other substrates. However, this core component clearly mediates independently several other physiological roles in the cell/neuron. Besides...