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Keywords: ATM
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Biochem Soc Trans (2023) 51 (1): 207–221.
Published: 06 January 2023
... and XRCC4-XLF. DSBs signal via ATM and CHK2, primarily but not exclusively via p53, to G1 cell cycle arrest. ICL (interstrand cross-links) induced endogenously and environmentally by, e.g. acrolein and therapeutically by CisPt ( cis - or carboplatin) are repaired by the FA (Fanconi anaemia) pathway when...
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Biochem Soc Trans (2020) 48 (2): 677–691.
Published: 27 March 2020
..., DNA repair and cell cycle transitions. The importance of the DDR is highlighted by the fact that DDR inactivation is commonly found in cancer and causes many different human diseases. The protein kinases ATM and ATR, as well as their budding yeast orthologs Tel1 and Mec1, act as master regulators...