... resection and promote NHEJ that would be fatal with this type of DS end [ 13 , 18 ]. These resected DSBs also activate the DDR cell cycle checkpoint kinases: ATR, CHK1 and WEE1 [ 19 ]. BRCA2 recruits RAD51 to allow invasion of the complementary chromatid template for high fidelity template-directed repair...

..., DNA repair and cell cycle transitions. The importance of the DDR is highlighted by the fact that DDR inactivation is commonly found in cancer and causes many different human diseases. The protein kinases ATM and ATR, as well as their budding yeast orthologs Tel1 and Mec1, act as master regulators...