...Glorianne Lazaro; Eleftherios Kostaras; Igor Vivanco Aberrant activation of the PI3K pathway is one of the commonest oncogenic events in human cancer. AKT is a key mediator of PI3K oncogenic function, and thus has been intensely pursued as a therapeutic target. Multiple AKT inhibitors, broadly...

...Katharina M. Siess; Thomas A. Leonard Akt is an essential protein kinase activated downstream of phosphoinositide 3-kinase and frequently hyperactivated in cancer. Canonically, Akt is activated by phosphoinositide-dependent kinase 1 and mechanistic target of rapamycin complex 2, which phosphorylate...

... in our understanding of its localization and regulation by ubiquitination and SUMOylation. 1 To whom correspondence should be addressed (email [email protected] ). 26 11 2015 © 2016 Authors; published by Portland Press Limited 2016 AKT cancer phosphatase phosphoinositide 3...

...-kinase (PI3K)/Akt signalling cascade. Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell survival, growth, proliferation and metabolism. Strikingly, non-redundant and even opposing functions of Akt isoforms in the regulation of phenotypes associated...

...Aswin G. Abraham; Eric O’Neill Mutations activating the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway and inactivating the TP53 tumour-suppressor gene are common mechanisms that cancer cells require to proliferate and escape pre-programmed cell death. In a well-described mechanism, Akt...

...Camilla Norrmén; Ueli Suter Akt signalling has emerged as one of the major pathways involved in myelination, implicated in the regulation of several steps during the development of myelinating Schwann cells and oligodendrocytes. One of the main pathways intimately linked with Akt is mTOR [mammalian...

...Edita Aksamitiene; Anatoly Kiyatkin; Boris N. Kholodenko In the present paper, we describe multiple levels of cross-talk between the PI3K (phosphoinositide 3-kinase)/Akt and Ras/MAPK (mitogen-activated protein kinase) signalling pathways. Experimental data and computer simulations demonstrate...

... encoding enzymes required for fatty acid and cholesterol biosynthesis. Lipid metabolism is perturbed in some diseases and SREBP target genes, such as FASN (fatty acid synthase), have been shown to be up-regulated in some cancers. We have previously shown that mTORC1 plays a role in SREBP activation and Akt...

... compilation © 2011 Biochemical Society 2011 Akt AZD8055 mammalian target of rapamycin complex (mTORC) mammalian target of rapamycin kinase (mTOR kinase) oncology mTOR (mammalian target of rapamycin) has been recognized as an essential component of tumour development and progression [ 1...

... genes by the SREBP (sterol-regulatory-element-binding protein) transcription factor, a central regulator of expression of lipogenic genes, to the control of cell size in vitro and cell and organ size in vivo . Several reports have linked SREBP and its target genes with components of the PI3K/Akt...

... subunit of PI3K and causes the PI3K-dependent phosphorylation of Akt (protein kinase B). Given that recombinant influenza A viruses unable to activate PI3K signalling are attenuated in tissue culture, the PI3K pathway could be a novel target for the development of future anti-influenza drugs. PI3K...

...J.-H. Paik The mammalian FoxO (forkhead box O) transcription factors FoxO1, FoxO3 and FoxO4 represent one of several effector arms of the PI3K (phosphoinositide 3-kinase)–Akt signalling network that has been linked to cancer, metabolism and aging. Specific roles of the FoxOs in the vascular cell...

... region, the level of PtdIns(3,4) P 2 is increased more in the nascent lamellipodia than in the plasma membrane. The distribution and time course of Akt activation are similar to those of increased PtdIns(3,4) P 2 levels. These observations suggest that the increase in PtdIns(3,4) P 2 and the subsequent...

... Akt activation. However, in the PC12 cell model, a lesser Akt activation during the first 6 h of OGD is associated with a reduction in cell death, indicating that in the context of tolerance, modulation rather than full activation of Akt can be beneficial. A possible explanation for this apparent...

... transporters are endocytosed and degraded in the lysosome, effectively terminating the cell's ability to obtain nutrients. This results in a state of pseudostarvation in which cells atrophy and initiate a catabolic metabolic programme in the midst of abundant extracellular nutrients. Oncogenic forms of Akt can...

... few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotypes of these PKB/Akt overexpression and mutant mice that may help to elucidate the functions exerted by PKB/Akt in mammals. 350...

... 2003 Biochemical Society 2003 acetyl-CoA carboxylase Akt atherosclerosis diacylglycerol fatty acid oxidation fuel sensing oxidative stress protein kinase C tumour necrosis factor α Abbreviations used: ACC, acetyl-CoA carboxylase; AICAR, 5-amino-4-imidazolecarboxamide riboside...

[email protected] ) 11 3 2002 © 2002 Biochemical Society 2002 AKT CKI dual-specificity tyrosine-phosphorylated and -regulated kinase (DYRK) forkhead nuclear exclusion PI 3-kinase, phosphoinositide 3-kinase PKB, protein kinase B PDKI, 3-phosphoinositide-dependent kinase-1 GSK3...

... in the future. Akt PKB PI 3-kinase PKC protein kinase AGC kinase AMPK, AMP-activated protein kinase ARF, ADP-ribosylation factor eIF2B, eukaryotic initiation factor 2B ERK, extracellular-signal-regulated kinase ES cells, embryonic stem cells GSK3, glycogen synthase kinase 3 IGF, insulin-like...