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1-18 of 18
Keywords: Alzheimer's disease (AD)
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Articles
The relationship between subcortical tau pathology and Alzheimer's disease
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 711–715.
Published: 20 July 2012
... not follow either Braak Lewy body staging [ 12 ] or McKeith criteria [ 13 ]). Alzheimer's disease (AD) Braak stages brainstem neuropathology subcortical tau pathology AD (Alzheimer's disease) is neuropathologically characterized by the presence of extracellular Aβ (amyloid β-peptide) as Aβ...
Articles
FDG–PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 874–880.
Published: 20 July 2011
... Society 2011 Alzheimer's disease (AD) imaging positron-emission tomography (PET) power spectrum quantitative electroencephalogram sleep Translational research requires biomarkers that (i) can be obtained both in clinic and preclinic; (ii) are reproducible, graded and sensitive (>80...
Articles
Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer's disease pathology
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 902–909.
Published: 20 July 2011
... and the frontal cortex respectively (see [ 42 ] for a recent review). 2 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) dentate gyrus (DG) episodic-like memory hippocampal synaptic activity pattern separation...
Articles
Can neurodegeneration be separated from neuropathological hallmarks of chronic idiopathic human neurodegenerative disease? A perspective from modelling!
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 917–919.
Published: 20 July 2011
... Alzheimer's disease (AD) amyloid deposit chronic neurodegenerative disease gliosis neuron Chronic neurodegenerative diseases including Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease are characterized by the neuropathological features of deposits of so-called amyloidogenic...
Articles
Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 924–932.
Published: 20 July 2011
... detrimental effects. 1 email [email protected] 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration ApoE, a 299-amino-acid glycoprotein...
Articles
Axon–glial disruption: the link between vascular disease and Alzheimer's disease?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 881–885.
Published: 20 July 2011
... The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) axon–glial integrity hypoperfusion vascular disease white matter The integrity of the white matter is critical in regulating efficient neuronal communication and maintaining...
Articles
‘Alzheimer-like’ pathology in a murine model of arterial hypertension
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 939–944.
Published: 20 July 2011
... ). 6 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) arterial hypertension lipopolysaccharide murine model AD is the leading cause of dementia in the elderly and, although some treatments help...
Articles
Systemic inflammation and delirium: important co-factors in the progression of dementia
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 945–953.
Published: 20 July 2011
... Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales Lancet 2001 357 169 175 Alzheimer's disease (AD) animal model delirium dementia microglia microglial priming systemic inflammation It has been known for many years...
Articles
Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 857–861.
Published: 20 July 2011
... compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) amyloid precursor protein (APP) human pathology intraneuronal amyloid β-peptide (intraneuronal Aβ) neuron loss Figure 2 Schematic drawing of the generation of Aβ pE3–42 oligomers...
Articles
Systemic inflammation and Alzheimer's disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 898–901.
Published: 20 July 2011
... for a number of recognized risk factors in the development and progression of AD and highlights the potential of the manipulation of systemic innate immunity as a novel therapeutic approach. 27 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD...
Articles
Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 891–897.
Published: 20 July 2011
... opens up a whole range of problems [ 60 , 61 , 63 – 66 ]. Alzheimer's disease (AD) central nervous system (CNS) glucagon-like peptide-1 (GLP1) insulin receptor substrate (IRS) Type 2 diabetes mellitus (T2DM) AD (Alzheimer's disease) is a progressive neurodegenerative disease for which...
Articles
Mitochondrial β-amyloid in Alzheimer's disease
Available to PurchaseEva Borger, Laura Aitken, Kirsty E.A. Muirhead, Zoe E. Allen, James A. Ainge, Stuart J. Conway, Frank J. Gunn-Moore
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 868–873.
Published: 20 July 2011
... degradation and causing ROS production, which leads to an increase in cytosolic Ca 2+ (7). Ca 2+ -mediated Cdk5 activation has been found to inhibit Prdx-2's antioxidant function. Alzheimer's disease (AD) amyloid-binding alcohol dehydrogenase (ABAD) cyclohexenyl amine naphthalene alcohol (CHANA...
Articles
Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation
Available to PurchaseAnnakaisa Haapasalo, Jayashree Viswanathan, Lars Bertram, Hilkka Soininen, Rudolph E. Tanzi, Mikko Hiltunen
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (1): 150–155.
Published: 19 January 2010
... that potentially influence neurodegeneration. 1 To whom correspondence should be addressed (e-mail [email protected] ). 1 7 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 aggresome Alzheimer's disease (AD) presenilin proteasome protein aggregation...
Articles
Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1096–1100.
Published: 26 October 2005
... in BACE expression, in post-mortem brain tissue and platelets from individuals with AD. Alzheimer's disease (AD) amyloid precursor protein (APP) β-site amyloid precursor protein-cleaving enzyme (BACE) cholesterol platelet post-mortem brain protease An increase in β-secretase activity would...
Articles
Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1033–1036.
Published: 26 October 2005
... The Biochemical Society 2005 Alzheimer's disease (AD) β-amyloid cholesterol insulin memory protein kinase C (PKC) Both insulin and cholesterol have long been considered part of the biochemical ‘furniture’ of the cell. However, recent evidence has shown that both insulin and cholesterol also...
Articles
Novel heparan sulphate analogues: inhibition of β-secretase cleavage of amyloid precursor protein
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1116–1118.
Published: 26 October 2005
.... Sadler I.I.J. Hawtin S.R. Tailor V.J. Shearman M.S. Neurosci. Lett. 1995 184 113 116 15 Scholefield Z. Yates E.A. Wayne G. Amour A. McDowell W. Turnbull J.E. J. Cell Biol. 2003 163 97 107 Alzheimer's disease (AD) amyloid precursor...
Articles
Molecular characterisation of the alzheimer's amyloid precursor protein secretases
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (1998) 26 (3): S245.
Published: 01 August 1998
.... and Harmar, A.J., eds p.200-204, John Wiley & Sons Ltd Turner, A.J. and Hooper, N.M. (1997) Biochem. J. 327,37-43 Clin. Invest. 1,263-280 6. Parvathy, S., Oppong, S.Y., Karran, E.H., Buckle, D.R., © 1998 Biochemical Society 1998 Alzheimer's disease (AD) β-amyloid protein (βA4) β-amyloid precursor...
Articles
Glutamate neurotoxicity: A role for non-n-Methyl-d-aspartate receptors?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (1): 18S.
Published: 01 February 1993
...RUTH M. DUBERLEY; CAROLE R. RICKARDS; JACK HAM; MAURICE F. SCANLON © 1993 Biochemical Society 1993 Alzheimer's Disease (AD) N-methyl-D-aspartate (NMDA) Kainic acid (KA) Quisqualate (Q) Choline acetyltransferase (CHAT) muscarinic acetylcholine receptor (mAchr) inositol monophosphate...