... not follow either Braak Lewy body staging [ 12 ] or McKeith criteria [ 13 ]). Alzheimer's disease (AD) Braak stages brainstem neuropathology subcortical tau pathology AD (Alzheimer's disease) is neuropathologically characterized by the presence of extracellular Aβ (amyloid β-peptide) as Aβ...

... Society 2011 Alzheimer's disease (AD) imaging positron-emission tomography (PET) power spectrum quantitative electroencephalogram sleep Translational research requires biomarkers that (i) can be obtained both in clinic and preclinic; (ii) are reproducible, graded and sensitive (>80...

... and the frontal cortex respectively (see [ 42 ] for a recent review). 2 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) dentate gyrus (DG) episodic-like memory hippocampal synaptic activity pattern separation...

... Alzheimer's disease (AD) amyloid deposit chronic neurodegenerative disease gliosis neuron Chronic neurodegenerative diseases including Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease are characterized by the neuropathological features of deposits of so-called amyloidogenic...

... detrimental effects. 1 email [email protected] 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration ApoE, a 299-amino-acid glycoprotein...

... The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) axon–glial integrity hypoperfusion vascular disease white matter The integrity of the white matter is critical in regulating efficient neuronal communication and maintaining...

... ). 6 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) arterial hypertension lipopolysaccharide murine model AD is the leading cause of dementia in the elderly and, although some treatments help...

... Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales Lancet 2001 357 169 175 Alzheimer's disease (AD) animal model delirium dementia microglia microglial priming systemic inflammation It has been known for many years...

... compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) amyloid precursor protein (APP) human pathology intraneuronal amyloid β-peptide (intraneuronal Aβ) neuron loss Figure 2 Schematic drawing of the generation of Aβ pE3–42 oligomers...

... for a number of recognized risk factors in the development and progression of AD and highlights the potential of the manipulation of systemic innate immunity as a novel therapeutic approach. 27 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD...

... opens up a whole range of problems [ 60 , 61 , 63 – 66 ]. Alzheimer's disease (AD) central nervous system (CNS) glucagon-like peptide-1 (GLP1) insulin receptor substrate (IRS) Type 2 diabetes mellitus (T2DM) AD (Alzheimer's disease) is a progressive neurodegenerative disease for which...

... degradation and causing ROS production, which leads to an increase in cytosolic Ca 2+ (7). Ca 2+ -mediated Cdk5 activation has been found to inhibit Prdx-2's antioxidant function. Alzheimer's disease (AD) amyloid-binding alcohol dehydrogenase (ABAD) cyclohexenyl amine naphthalene alcohol (CHANA...

... that potentially influence neurodegeneration. 1 To whom correspondence should be addressed (e-mail [email protected] ). 1 7 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 aggresome Alzheimer's disease (AD) presenilin proteasome protein aggregation...

... in BACE expression, in post-mortem brain tissue and platelets from individuals with AD. Alzheimer's disease (AD) amyloid precursor protein (APP) β-site amyloid precursor protein-cleaving enzyme (BACE) cholesterol platelet post-mortem brain protease An increase in β-secretase activity would...

... The Biochemical Society 2005 Alzheimer's disease (AD) β-amyloid cholesterol insulin memory protein kinase C (PKC) Both insulin and cholesterol have long been considered part of the biochemical ‘furniture’ of the cell. However, recent evidence has shown that both insulin and cholesterol also...

.... Sadler I.I.J. Hawtin S.R. Tailor V.J. Shearman M.S. Neurosci. Lett. 1995 184 113 116 15 Scholefield Z. Yates E.A. Wayne G. Amour A. McDowell W. Turnbull J.E. J. Cell Biol. 2003 163 97 107 Alzheimer's disease (AD) amyloid precursor...

.... and Harmar, A.J., eds p.200-204, John Wiley & Sons Ltd Turner, A.J. and Hooper, N.M. (1997) Biochem. J. 327,37-43 Clin. Invest. 1,263-280 6. Parvathy, S., Oppong, S.Y., Karran, E.H., Buckle, D.R., © 1998 Biochemical Society 1998 Alzheimer's disease (AD) β-amyloid protein (βA4) β-amyloid precursor...

...RUTH M. DUBERLEY; CAROLE R. RICKARDS; JACK HAM; MAURICE F. SCANLON © 1993 Biochemical Society 1993 Alzheimer's Disease (AD) N-methyl-D-aspartate (NMDA) Kainic acid (KA) Quisqualate (Q) Choline acetyltransferase (CHAT) muscarinic acetylcholine receptor (mAchr) inositol monophosphate...