... of squamous cells or through Barrett's metaplasia. 1 email rhonda.souza@utsouthwestern.edu 27 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 Barrett's metaplasia bile acid gastro-oesophageal reflux disease (GORD) oesophagitis The prevailing...

...James Cronin; Lisa Williams; Elizabeth McAdam; Zak Eltahir; Paul Griffiths; John Baxter; Gareth Jenkins Bile acids have been demonstrated, through the use of animal models and clinical association studies, to play a role in neoplastic development in Barrett's metaplasia. How specific bile acids...

...Jonathan M.W. Slack; Benjamin J. Colleypriest; Jonathan M. Quinlan; Wei-Yuan Yu; Mark J. Farrant; David Tosh Barrett's metaplasia is discussed in the context of a general theory for the formation of metaplasias based on developmental biology. The phenotype of a particular tissue type becomes...

... of the transcription factors that specify tissue identity during normal embryonic development. Barrett's metaplasia describes the development of a columnar/intestinal phenotype in the squamous oesophageal epithelium and is the major risk factor for oesophageal adenocarcinoma. This particular type of cancer has...