...Adjanie Patabendige; Damir Janigro A healthy brain is protected by the blood–brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeostasis of the brain...

...Keith D. Rochfort; Philip M. Cummins An intact functioning blood–brain barrier (BBB) is fundamental to proper homoeostatic maintenance and perfusion of the central nervous system (CNS). Inflammatory damage to the unique microvascular endothelial cell monolayer that constitutes the luminal BBB...

..., during oxidative stress, plasma oxycholesterols could have damaging effects on BBB (blood–brain barrier) function and consequently on neuronal cells. Cholesterol-lowering drugs such as statins may prevent the modifications to LDL in mid-life and might show beneficial effects in later life. 1...

...Stephen McQuaid; Paula Cunnea; Jill McMahon; Una Fitzgerald Dysfunction of the BBB (blood–brain barrier) is a major hallmark of MS (multiple sclerosis). Studies in our laboratories over the last decade have shown that increased BBB permeability is associated with decreased expression of TJ (tight...

... be addressed (email [email protected] ). 11 8 2006 © 2006 The Biochemical Society 2006 blood–brain barrier dystroglycan extracellular matrix focal ischaemia integrin matrix adhesion receptor Integrins are cell-surface transmembrane, non-covalently-linked αβ heterodimers...

...C.M. Maier; L. Hsieh; T. Crandall; P. Narasimhan; P.H. Chan Effective stroke therapies require recanalization of occluded cerebral blood vessels; however, early reperfusion can cause BBB (blood–brain barrier) injury, leading to cerebral oedema and/or devastating brain haemorrhage...

...A.G. MacLean; T.A. Rasmussen; D. Bieniemy; A.A. Lackner The primary cell infected during acute HIV neuropathogenesis is the monocyte-derived macrophage. We have demonstrated that there is activation of the BBB (blood–brain barrier) during acute viral infection and at terminal AIDS. However, it has...