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Keywords: C1 domain
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Articles
C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure–activity relationships and biological activities
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1543–1549.
Published: 17 November 2014
...-based approach on the crystal structure of the PKCδ C1B domain, our team has developed isophthalic acid derivatives that are able to modify PKC functions by binding to the C1 domain of the enzyme. Bis[3-(trifluoromethyl)benzyl] 5-(hydroxymethyl)isophthalate (HMI-1a3) and bis(1-ethylpentyl) 5...
Articles
The lipid second messenger diacylglycerol as a negative regulator of Rac signalling
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 855–857.
Published: 25 October 2006
[email protected] ). β2-chimaerin C1 domain diacylglycerol epidermal growth factor receptor (EGFR) phorbol ester phospholipase Cγ (PLCγ) Rac1 For many years, it has been widely conceived that PKC (protein kinase C) is the only family of intracellular receptors for the lipid second messenger DAG...
