... correctly positioned at the 5′ end of the viral transcripts is sufficient to protect from Nsp1-mediated degradation [ 50 ]. Coronaviruses COVID-19 mRNA translation Nsp1 SARS-CoV-2 viral infection In recent years, the emergence of SARS-CoV-2, the coronavirus responsible for the COVID-19...

...Xiyuan Bai; Tony Schountz; Ashley M. Buckle; Janet L. Talbert; Robert A. Sandhaus; Edward D. Chan Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID-19. Herein, we...

... are at risk of severe complications from COVID-19. Correspondence: Menno C. van Zelm ( [email protected] ) 14 7 2022 8 11 2022 9 11 2022 © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...

...-morbidity Covid-19 insulin signaling type-2 diabetes Figure 2. Schematic representation of the possible signaling pathways involved in SARS-Cov2 infection and Type-2 Diabetes co-morbidity. Inhibition, Possible activation, Possible Inhibition. With the current knowledge...

...Anoop Narayanan; Shay A. Toner; Joyce Jose SARS-CoV-2, the coronavirus responsible for the current COVID-19 pandemic, encodes two proteases, 3CL pro and PL pro , two of the main antiviral research targets. Here we provide an overview of the structures and functions of 3CL pro and PL pro and examine...

... access for this article was enabled by the participation of Monash University in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. COVID-19 SARS-CoV-2 structural biology The causative agent...

...Jiayue-Clara Jiang; Yan Zhang The ongoing COVID-19 pandemic has placed an overwhelming burden on the healthcare system, and caused major disruption to the world economy. COVID-19 is caused by SARS-CoV-2, a novel coronavirus that leads to a variety of symptoms in humans, including cough, fever...

...Spencer J. Williams; Ethan D. Goddard-Borger The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipitated social distancing measures that have crippled economic activities across the globe. A return to normality is unlikely...