... cleavage Creutzfeldt–Jakob disease octapeptide repeat prion processing reactive oxygen species (ROS) ADAM a disintegrin and metalloproteinase CDP chronic demyelinating polyneuropathy CJD Creutzfeldt–Jakob disease OR octapeptide repeat PrP prion protein PrP C...

... 1 11 2004 © 2005 The Biochemical Society 2005 Alzheimer's disease amyloid precursor protein Creutzfeldt–Jakob disease GPI anchor lipid raft prion protein AD Alzheimer's disease ADAM a disintegrin and metalloproteinase APP amyloid precursor protein Aβ...

... disease protein misfolding scrapie CJD, Creutzfeldt-Jakob disease TSE, transmissible spongiform encephalopathy PMCA, protein misfolding cyclic amplification Amyloidogenic Proteins Involved in Neurodegeneration and Therapeutic Implications 32 33 34 35 36 37 38 39 Gabizon, R., Meiner, Z...

... strong evidence to suggest that apart from this difference in resistance a major difference between the isoforms is that the normal prion protein binds copper and has an anti-oxidant function. Brains from Creutzfeldt-Jakob disease patients and brains from mice with experimental mouse scrapie have been...