... agreement with JISC. DNA damage response DNA synthesis and repair genome integrity post translational modification SUMOylation ubiquitin signalling SUMOylation is a protein post-translational modification whereby SUMOs are covalently attached to target lysine residues. Mature SUMO2...

...Nicola J. Curtin The DNA damage response (DDR) is an elegant system, coordinating DNA repair with cell cycle checkpoints, that evolved to protect living organisms from the otherwise fatal levels of DNA damage inflicted by endogenous and environmental sources. Since many agents used to treat cancer...

... checkpoint surveillance. We outline mechanisms that regulate the mitotic DNA damage response and the different types of lesions that are carried over to mitosis, with a focus on joint DNA molecules arising from under-replication and persistent recombination intermediates, as well as DNA catenanes...

... of PARPi. We note that not all PARP inhibitors trap PARP2 equally. Olaparib shows significantly more moderate trapping [ 16 ]. cancer therapy DNA damage response live-cell imaging PARP inhibitors PARP1 PARP2 Poly (ADP-ribose) polymerase-1 (PARP1) and 2 (PARP2) are activated by DNA...

... of regulatory modules for HSP70 allows the elucidation of HSP70 specificity and target selectivity. Here, we discuss how the HSP70 cycle is functionally linked with the cycle of the Ubiquitin-like molecule NEDD8. Using as an example the DNA damage response, we present a model where HSP70 acts as a sensor...

... and thus can be utilized to detect low to high form of serous carcinoma. In this review, we have focused on ovarian cancer which is largely caused by genomic alterations in the DNA damage response pathways utilizing proteins like RAD51, BRCA1, 53BP1 which are regulated by lamins. We have elucidated...

..., termed DNA damage response (DDR). The DDR comprises both mechanisms devoted to repair DNA lesions and signal transduction pathways that sense DNA damage and transduce this information to specific cellular targets. These targets, in turn, impact a wide range of cellular processes including DNA replication...

... and malignant cells following replication stress. Correspondence: Robert S. Weiss ( [email protected] ) 12 9 2018 5 11 2018 7 11 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 DNA damage response DNA replication...

... proteins by poly(ADP-ribosyl)ation, namely PARP1, PARP2, Tankyrase-1, and Tankyrase-2. Here, we detail the cellular functions of PARP1 and PARP2 in the regulation of DNA damage response and describe the function of Tankyrases in Wnt-mediated signal transduction. Furthermore, we discuss how...

.... Lichtensztejin D. Grotsky D. Morgado-Palacin L. Gapud E.J. Sleckman B.P. Sullivan T. Novel roles for A-type lamins in telomere biology and DNA damage response pathway EMBO J. 2009 28 2414 2427 35 Dimitrova N. Chen Y.C. Spector D.L. de Lange T. 53BP1...