...Narottam Acharya; Shraddheya Kumar Patel; Satya Ranjan Sahu; Premlata Kumari Interaction of PCNA with DNA polymerase is vital to efficient and processive DNA synthesis. PCNA being a homotrimeric ring possesses three hydrophobic pockets mostly involved in an interaction with its binding partners...

...Pierre Raia; Marc Delarue; Ludovic Sauguet Replicative DNA polymerases are nano-machines essential to life, which have evolved the ability to copy the genome with high fidelity and high processivity. In contrast with cellular transcriptases and ribosome machines, which evolved by accretion...