... License 4.0 (CC BY-NC-ND) . antibiotic resistance argonaute DNA synthesis and repair topoisomerases Argonaute proteins are ubiquitous nucleic acid-guided nucleases found in both prokaryotes and eukaryotes [ 1–7 ]. Eukaryotic Argonaute proteins (eAgos) are highly conserved and found...

... agreement with JISC. DNA damage response DNA synthesis and repair genome integrity post translational modification SUMOylation ubiquitin signalling SUMOylation is a protein post-translational modification whereby SUMOs are covalently attached to target lysine residues. Mature SUMO2...

...) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . DNA double-strand break repair DNA synthesis and repair DNA-PK NHEJ Non-Homologous end-joining...

... with Portland Press and the Biochemical Society under a transformative agreement with JISC. ADP-ribosylation DNA synthesis and repair PARP A PTM important in the DDR is ADP-ribosylation, a reversible covalent attachment of ADP-ribose (ADPr) moieties to proteins. In humans, the largest protein...

... of Oxford in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. cGAS-STING chromosomal instability DNA synthesis and repair immunosurveillance innate immunity Chromosomal instability, characterised...

... ( [email protected] ) 4 11 2021 20 12 2021 22 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 DNA synthesis and repair nucleotide excision repair structural biology Removal of the damaged DNA depends...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cell cycle centrosomes cilia DNA synthesis and repair The DNA damage response (DDR) is a complex biochemical signalling network that detects and responds to DNA damage, activating multiple pathways...

... this flow are O-GlcNAc modified, and their functions are tuned by the cycling sugar. Herein, we review the regulatory roles of O-GlcNAcylation on the epigenome, in DNA replication and repair, in transcription and in RNA processing, in protein translation and in protein turnover. DNA synthesis...

... DNA replication and recombination DNA synthesis and repair mutagenesis phenotypic heterogeneity single-cell analysis Figure 1. Sources of heterogeneity in DNA repair. Various molecular processes involved in DNA repair are inherently stochastic, including the random search of repair...

... interacts with and stabilises the MDC1–MRN complex [ 26 ]. DNA synthesis and repair double strand break DUB SENP sumoylation ubiquitin DNA double stranded breaks are highly toxic lesions that occur when both strands of DNA are broken. The breaks can be formed from endogenous processes...

... on behalf of the Biochemical Society 2018 cancer DNA replication and recombination DNA synthesis and repair genetic disease genome integrity helicase Although RECQL4 lacks a WH domain, the C-terminal region of the protein is critical for helicase activity [ 2 ]. Nonetheless, the apparent...

... of GFP (green fluorescent protein) or YFP (yellow fluorescent protein) using photobleaching-assisted or reactivation localization [ 44 ]. DNA synthesis and repair Gram-negative bacteria live-cell imaging microbiology single-molecule imaging Maintaining genomic integrity is critical...