... to extrude DNA into large loop structures and the capacity to alter the superhelicity of the DNA double helix. In this review, we explore the influence of eukaryotic SMC complexes on DNA topology, debate its potential physiological function, and discuss new structural insights that may explain how...

... encounter similar DNA topology issues, the distribution of topoisomerases varies from one bacterium to another, suggesting polymorphic functioning. Recently, several proteins restricting, enhancing or modifying the activity of topoisomerases were discovered, opening the way to a new area of understanding...

...-resolution fluorescence microscope. 1 To whom correspondence should be addressed (email [email protected] ). 19 9 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 DNA topology localization microscopy millisecond microscopy multidimensional microscopy...

.... Figure 1 Site-specific recombination and DNA topology ( A ) Serine recombinases cleave all four strands of the recombination core sites, forming an intermediate in which the protein is covalently attached to the DNA via catalytic serine residues. Strand exchange by a subunit rotation mechanism joins...

...Ksenia Terekhova; John F. Marko; Alfonso Mondragón Topoisomerases are the enzymes responsible for maintaining the supercoiled state of DNA in the cell and also for many other DNA-topology-associated reactions. Type IA enzymes alter DNA topology by breaking one DNA strand and passing another strand...

... Correspondence may be addressed to either author (email [email protected] or [email protected] ). 12 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 crossing-sign discrimination DNA topology knot-reduction self-avoiding polygon strand-passage model...

...Jorge B. Schvartzman; María-Luisa Martínez-Robles; Pablo Hernández; Dora B. Krimer DNA topology changes dynamically during DNA replication. Supercoiling, precatenation, catenation and knotting interplay throughout the process that is finely regulated by DNA topoisomerases. In the present article...

... as internal and environmental factors, may affect DNA topology, raising the need for mechanisms for its homoeostatic control. This is mainly due to the direct action of DNA topoisomerases that modify the DNA linking number enzymatically [ 1 , 2 ] and to several types of DNA-binding proteins that are able...

... should be addressed (email [email protected] ). 30 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 archaeon DNA topology genome stability helicase hyperthermophile topoisomerase DNA topoisomerases are essential enzymes that regulate...

...A.J. Schoeffler; J.M. Berger DNA topos (topoisomerases) are complex, multisubunit enzymes that remodel DNA topology. Members of the type II topo family function by passing one segment of duplex DNA through a transient break in another, a process that consumes two molecules of ATP and requires...