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Keywords: DNA-PK
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Biochem Soc Trans (2023) 51 (5): 1789–1800.
Published: 03 October 2023
... to join one strand of the DSB then the other [ 54 ]. DNA double-strand break repair DNA synthesis and repair DNA-PK NHEJ Non-Homologous end-joining (NHEJ) is the major pathway for the repair of ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) in both quiescent...
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Biochem Soc Trans (2023) 51 (1): 207–221.
Published: 06 January 2023
... exclusively by NHEJ (non-homologous end-joining) which involves the recognition, stabilisation and synapsis of the break by DNA-dependent protein kinase DNA-PK, a heterodimeric complex of KU70 and Ku80 and the catalytic subunit, DNA-PKcs, modest end resection, limited by 53BP1, and end ligation by Ligase 4...